LMNB1 - lamin B1 Gene

Also Known as LMN; ADLD; LMN2; LMNB; MCPH26

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4001

About LMNB1

Cytogenetic location: 5q23.2 Genomic coordinates (GRCh38): 5:126,776,623-126,837,020 (from NCBI)

This gene has 8 transcripts (splice variants), 188 orthologues, 68 paralogues and is associated with 5 phenotypes. Broad expression in lymph node (RPKM 25.5), appendix (RPKM 22.1) and 18 other tissues.

Summary

This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

LMNB1 Products (2)

mRNA	Protein	Name
NM_001198557.2	NP_001185486.1	lamin-B1 isoform 2
NM_005573.4	NP_005564.1	lamin-B1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21346760	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in nuclear envelope organization	IMP IMP: Inferred from mutant phenotype	32910914	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with nuclear envelope	IDA IDA: Inferred from direct assay	21610090	GOA
located in nuclear lamina	IMP IMP: Inferred from mutant phenotype	32910914	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10791971	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LMNB1 Protein Structure

Filament

LTD

0
100
200
300
400
500
586 a.a.

Protein Preferred Names	Protein Names
lamin-B1

LMNB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LMNB1	P20700	CENPH	Homo sapiens	Q9H3R5	Y2H Array	32296183
Intra	LMNB1	P20700	CENPH	Homo sapiens	Q9H3R5	Y2H Prey Pooling	32296183
Intra	LMNB1	P20700	CENPH	Homo sapiens	Q9H3R5	Validated Y2H	32296183
Intra	LMNB1	P20700	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	LMNB1	P20700	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	LMNB1	P20700	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	LMNB1	P20700	PIH1D2	Homo sapiens	Q8WWB5	Y2H Prey Pooling	32296183
Intra	LMNB1	P20700	PIH1D2	Homo sapiens	Q8WWB5	Validated Y2H	32296183
Intra	LMNB1	P20700	PIH1D2	Homo sapiens	Q8WWB5	Y2H Array	32296183
Intra	LMNB1	P20700	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Prey Pooling	32296183
Intra	LMNB1	P20700	PPP1R13B	Homo sapiens	Q96KQ4	Validated Y2H	32296183
Intra	LMNB1	P20700	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Array	32296183
Intra	LMNB1	P20700	TP53BP2	Homo sapiens	Q05BL1	Validated Y2H	32296183
Intra	LMNB1	P20700	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	LMNB1	P20700	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	LMNB1	P20700	FAM169A	Homo sapiens	Q9Y6X4	Y2H Prey Pooling	32296183
Intra	LMNB1	P20700	FAM169A	Homo sapiens	Q9Y6X4	Validated Y2H	32296183
Intra	LMNB1	P20700	FAM169A	Homo sapiens	Q9Y6X4	Y2H Array	32296183
Intra	LMNB1	P20700	LMNB2	Homo sapiens	Q03252	Y2H Array	32296183
Intra	LMNB1	P20700	LMNB2	Homo sapiens	Q03252	Anti Tag CoIP	35271311
Intra	LMNB1	P20700	LMNB2	Homo sapiens	Q03252	Y2H Prey Pooling	32296183
Intra	LMNB1	P20700	LMNB2	Homo sapiens	Q03252	Validated Y2H	32296183
Intra	LMNB1	P20700	LMNB2	Homo sapiens	Q03252	Anti Bait CoIP	26524528
Intra	LMNB1	P20700	SNAPIN	Homo sapiens	O95295	Y2H Array	32296183
Intra	LMNB1	P20700	SNAPIN	Homo sapiens	O95295	Y2H Prey Pooling	32296183
Intra	LMNB1	P20700	CCDC88B	Homo sapiens	A6NC98	Y2H Array	32296183
Intra	LMNB1	P20700	CCDC88B	Homo sapiens	A6NC98	Y2H Prey Pooling	32296183
Intra	LMNB1	P20700	LMNA	Homo sapiens	P02545	Anti Tag CoIP	35271311
Intra	LMNB1	P20700	LMNA	Homo sapiens	P02545	Lumier	37398436
Intra	LMNB1	P20700	LMNA	Homo sapiens	P02545	BRET	37398436
Intra	LMNB1	P20700	LMNA	Homo sapiens	P02545	Y2H	21988832
Intra	LMNB1	P20700	LMNA	Homo sapiens	P02545-1	Anti Bait CoIP	26524528
Intra	LMNB1	P20700	LMNA	Homo sapiens	P02545-1	Anti Tag CoIP	26524528
Intra	LMNB1	P20700	LMNA	Homo sapiens	P02545-1	Anti Tag CoIP	21346760
Intra	LMNB1	P20700	KPNA1	Homo sapiens	P52294	Y2H Array	32296183
Intra	LMNB1	P20700	KPNA1	Homo sapiens	P52294	Y2H Prey Pooling	32296183
Intra	LMNB1	P20700	KPNA1	Homo sapiens	P52294	Anti Tag CoIP	35271311
Intra	LMNB1	P20700	KPNA1	Homo sapiens	P52294	Validated Y2H	32296183
Intra	LMNB1	P20700	KPNA6	Homo sapiens	O60684	Anti Tag CoIP	35271311
Intra	LMNB1	P20700	KPNA6	Homo sapiens	O60684	Y2H Prey Pooling	32296183
Intra	LMNB1	P20700	KPNA6	Homo sapiens	O60684	Y2H Array	32296183
Intra	LMNB1	P20700	MAP1LC3B	Homo sapiens	Q9GZQ8	Anti Bait CoIP	26524528
Intra	LMNB1	P20700	DMAP1	Homo sapiens	Q9NPF5	Y2H Array	32296183
Intra	LMNB1	P20700	DMAP1	Homo sapiens	Q9NPF5	Y2H Prey Pooling	32296183
Intra	LMNB1	P20700	DMAP1	Homo sapiens	Q9NPF5	Validated Y2H	32296183
Intra	LMNB1	P20700	KPNA5	Homo sapiens	O15131	Y2H Prey Pooling	32296183
Intra	LMNB1	P20700	KPNA5	Homo sapiens	O15131	Y2H Array	32296183
Intra	LMNB1	P20700	M1AP	Homo sapiens	Q8TC57	Validated Y2H	32296183
Intra	LMNB1	P20700	M1AP	Homo sapiens	Q8TC57	Y2H Prey Pooling	32296183
Intra	LMNB1	P20700	M1AP	Homo sapiens	Q8TC57	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

LMNB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80205	Lamin B1 Antibody (YA313)	WB, IHC-P, IF-Tissue	Human, Mouse, Rat
HY-P84174	Lamin B1 Antibody (YA3871)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
HY-P84174A	Lamin B1 Antibody (YA3871)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
HY-P85637	Lamin B1 Antibody (YA5329)	WB	Human, Mouse, Monkey
HY-P85645	Lamin B1 Antibody(HRP) (YA5337)	WB, IHC-P	Human, Rat, Mouse
HY-P85651	Lamin B1 Antibody (YA5343)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P86574	Lamin B1 Antibody (YA6266)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86667	lamin B1 Antibody (YA6359)	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant	ADLD Adult-Onset Autosomal Dominant Demyelinating Leukodystrophy Leukodystrophy, Adult-Onset, Autosomal Dominant Adult-Onset Autosomal Dominant Leukodystrophy Autosomal Dominant Leukodystrophy With Autonomic Disease Autosomal Dominant Adult-Onset Demyelinating Leukodystrophy Multiple Sclerosis-Like Disorder Pelizaeus-Merzbacher Disease, Autosomal Dominant Or Late-Onset Type, Formerly Autosomal-Dominant Or Late-Onset Type Pelizaeus-Merzbacher Disease Pelizaeus-Merzbacher Disease, Autosomal Dominant Or Late-Onset Type Adult-Onset Autosomal Dominant Leukodystrophy With Autonomic Symptoms Lmnb1-Related Adult-Onset Autosomal Dominant Leukodystrophy Leukodystrophy, Demyelinating, Autosomal Dominant, Adult-Onset Pelizaeus-Merzbacher Disease Autosomal Dominant Pelizaeus-Merzbacher Disease Late-Onset Type Adult Onset Autosomal Dominant Leukodystrophy
Microcephaly 26, Primary, Autosomal Dominant	MCPH26
Microcephaly, Autosomal Dominant	Autosomal Dominant Microcephaly Microcephaly Autosomal Dominant Autosomal Dominant Primary Microcephaly Microcephaly With Autosomal Dominant Inheritance
Leukodystrophy	Leukodystrophies
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson Gilford Progeria Syndrome Hutchinson-Gilford Disease Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome
Lmnb1-Related Autosomal Dominant Leukodystrophy	Adult-Onset Autosomal Dominant Leukodystrophy With Autonomic Symptoms Autosomal Dominant Adult-Onset Demyelinating Leukodystrophy Autosomal Dominant Leukodystrophy With Autonomic Symptoms Lmnb1-Related Adld
Emery-Dreifuss Muscular Dystrophy	Edmd Emery-Dreifuss Syndrome Muscular Dystrophy, Emery-Dreifuss Humeroperoneal Neuromuscular Disease Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures Scapuloperoneal Syndrome, X-Linked Benign Scapuloperoneal Muscular Dystrophy With Early Contractures Muscular Dystrophy, Emery-Dreifuss Type Muscular Dystrophy Emery-Dreifuss Dystrophy, Muscular, Emery-Dreifuss Emd - [Emery-Dreifuss Muscular Dystrophy]
Familial Partial Lipodystrophy	Lipodystrophy, Familial Partial Fpld Kobberling-Dunnigan Syndrome Dunnigan Syndrome Koberling-Dunnigan Syndrome Dunnigan-Kobberling Syndrome Fpl Familial Partial Lipodystrophy, Type 2
Reynolds Syndrome	Primary Biliary Cirrhosis, Scleroderma, Raynaud Disease, And Telangiectasia Primary Biliary Cirrhosis And Systemic Scleroderma REYNS Primary Biliary Cirrhosis Scleroderma Raynaud Disease And Telangiectasia
Charcot-Marie-Tooth Disease, Axonal, Type 2b1	Charcot-Marie-Tooth Disease Type 2b1 Charcot-Marie-Tooth Disease, Type 2b1 CMT2B1 Autosomal Recessive Axonal Cmt4c1 Autosomal Recessive Charcot-Marie-Tooth Disease Type 2b1 Charcot-Marie-Tooth Disease Neuronal Type 2b1 Charcot-Marie-Tooth Neuropathy Type 2b1 Charcot-Marie-Tooth Disease, Neuronal, Type 2b1 Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2b1 Charcot-Marie-Tooth Neuropathy, Type 2b1 Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2b1 Ar-Cmt2b1 Charcot-Marie-Tooth Disease 2b1 Charcot-Marie-Tooth Disease Axonal Autosomal Recessive B1 Charcot-Marie-Tooth Disease Axonal Type 2b1
Muscular Dystrophy, Congenital, Lmna-Related	Congenital Muscular Dystrophy Congenital Muscular Dystrophy Due To Lmna Mutation MDCL L-Cmd Lmna-Related Congenital Muscular Dystrophy Muscular Dystrophy, Congenital Congenital Muscular Dystrophy Lmna-Related Lmna-Related Cmd Cmd Mdc Muscular Dystrophy Congenital Lmna-Related Dystrophy, Muscular, Congenital, Lmna-Related Dystrophy, Muscular, Congenital Hereditary Muscular Dystrophy Congenital Hereditary Muscular Dystrophy Congenital Progressive Muscular Dystrophy Hereditary Progressive Muscular Dystrophy
Lipodystrophy, Familial Partial, Type 2	FPLD2 Lipoatrophic Diabetes Familial Partial Lipodystrophy Type 2 Familial Partial Lipodystrophy, Dunnigan Type Fpl2 Lipoatrophic Diabetes Mellitus Lipodystrophy, Familial Partial, Dunnigan Type Lipodystrophy, Familial, Of Limbs And Lower Trunk Lipodystrophy, Reverse Partial Familial Partial Lipodystrophy Dunnigan Type Dunnigan Syndrome Familial Lipodystrophy Of Limbs And Lower Trunk Reverse Partial Lipodystrophy Lipodystrophy, Familial Partial, 2 Generalized Lipoatrophy Associated With Diabetes, Hepatic Steatosis, Hypertrophic Cardiomyopathy And Leukomelanodermic Papules Lipodystrophy Familial Of Limbs And Lower Trunk Lipodystrophy Reverse Partial Diabetes Mellitus, Lipoatrophic Familial Partial Lipodystrophy, Type 2 Familial Generalized Lipodystrophy
Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant	EDMD2 Autosomal Dominant Emery-Dreifuss Muscular Dystrophy Emd2 Emery-Dreifuss Muscular Dystrophy, Autosomal Dominant Scapuloilioperoneal Atrophy With Cardiopathy Muscular Dystrophy With Early Contractures And Cardiomyopathy, Autosomal Dominant Hauptmann-Thannhauser Muscular Dystrophy Cardiomyopathy, Dilated, With Quadriceps Myopathy Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 2 Muscular Dystrophy, Limb-Girdle, Type 1b Muscular Dystrophy, Limb-Girdle, Type 1b, Formerly Lgmd1b, Formerly Muscular Dystrophy, Proximal, Type 1b, Formerly Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1b Lgmd1b Limb-Girdle Muscular Dystrophy 1b Muscular Dystrophy, Proximal, Type 1b Muscular Dystrophy With Early Contractures And Cardiomyopathy Autosomal Dominant
Greenberg Dysplasia	Hem Dysplasia Greenberg Skeletal Dysplasia Hem Skeletal Dysplasia GRBGD Hydrops-Ectopic Calcification-Moth-Eaten Skeletal Dysplasia Moth-Eaten Skeletal Dysplasia Chondrodystrophy, Hydropic And Prenatally Lethal Type Hydrops-Ectopic Calcification-Motheaten Syndrome Skeletal Dysplasia, Greenberg Type Autosomal Recessive Lethal Chondrodystrophy With Congenital Hydrops Hydrops, Ectopic Calcification, Moth-Eaten Skeletal Dysplasia Hem Hem/Greenberg Dysplasia Hydrops - Ectopic Calcification - Moth-Eaten Skeletal Dysplasia
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Pelger-Huet Anomaly	PHA Pelger-Huët Anomaly Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities Pelger Huet Anomaly Pelger-Huet Nuclear Anomaly
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Partial Third-Nerve Palsy	Partial Third Nerve Palsy Third Nerve Palsy With Pupil Sparing Third Or Oculomotor Nerve Palsy, Partial Oculomotor Nerve Diseases Oculomotor Nerve Paralysis
Monocular Esotropia	Esotropia
Buschke-Ollendorff Syndrome	BOS Dermatoosteopoikilosis Dermatofibrosis Lenticularis Disseminata With Osteopoikilosis Osteopathia Condensans Disseminata Dermatofibrosis Lenticularis Disseminata Disseminated Dermatofibrosis With Osteopoikilosis Dermatofibrosis, Disseminated, With Osteopoikilosis Osteopoikilosis With Or Without Melorheostosis Dermatofibrosis, Disseminated With Osteopoikilosis Dermatofibrosis Disseminata Lenticularis Isolated Osteopoikilosis Osteopoikilosis, Isolated
Emery-Dreifuss Muscular Dystrophy 1, X-Linked	EDMD1 Emd1 Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures X-Linked Emery-Dreifuss Muscular Dystrophy 1 Humeroperoneal Neuromuscular Disease X-Linked Emery-Dreifuss Muscular Dystrophy Scapuloperoneal Syndrome, X-Linked, Formerly Humeroperoneal Neuromuscular Disease, Formerly Scapuloperoneal Syndrome, X-Linked Muscular Dystrophy Tardive Dreifuss-Emery Type With Contractures Scapuloperoneal Syndrome X-Linked X-Edmd Dystrophy, Muscular, Emery-Dreifuss, Type 1, X-Linked
Nonencapsulated Sclerosing Carcinoma	Nonencapsulated Sclerosing Neoplasm Papillary Carcinoma, Diffuse Sclerosing
Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive	EDMD3 Autosomal Recessive Emery-Dreifuss Muscular Dystrophy 3 Autosomal Recessive Emery-Dreifuss Muscular Dystrophy Emery-Dreifuss Muscular Dystrophy Atypical Autosomal Recessive Dystrophy, Muscular, Emery-Dreifuss, Type 3, Autosomal Recessive Emery-Dreifuss Muscular Dystrophy 3
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Emery-Dreifuss Muscular Dystrophy 4, Autosomal Dominant	EDMD4 Emery-Dreifuss Muscular Dystrophy 4 With Variable Features Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 4 Emd4 Dystrophy, Muscular, Emery-Dreifuss, Type 4, Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 4
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Cardiomyopathy, Dilated, 1h	Dilated Cardiomyopathy 1h Dilated Cardiomyopathy With Conduction Defect CMD1H Cardiomyopathy, Dilated, With Conduction Defect
Cerebral Degeneration	Brain Degeneration Degenerative Brain Disorder
Osteopoikilosis	Osteopathia Condensans Disseminata Spotted Bones Dermatofibrosis Lenticularis Disseminata
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Hyperoxaluria, Primary, Type I	Primary Hyperoxaluria Type 1 HP1 Glycolic Aciduria Alanine-Glyoxylate Aminotransferase Deficiency Hepatic Agt Deficiency Oxalosis I Primary Hyperoxaluria, Type I Serine:Pyruvate Aminotransferase Deficiency Hyperoxaluria, Primary, Type 1 Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency Serine Pyruvate Aminotransferase Deficiency Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Oxalosis 1 Hyperoxaluria Primary 1 Hyperoxaluria Primary Type I Ph1 Primary Hyperoxaluria Type I Oxalosis Type 1 2-Oxoglutarate Glyoxylate Carboligase Deficiency
Cardiomyopathy, Dilated, 1a	Dilated Cardiomyopathy 1a Cdcd1 CMD1A Cardiomyopathy, Familial Idiopathic Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation Cardiomyopathy, Dilated, With Conduction Defect 1 Cardiomyopathy, Idiopathic Dilated Cardiomyopathy, Congestive Dilated Cardiomyopathy With Conduction Defect 1 Cardiomyopathy Dilated With Conduction Defect Type 1 Cardiomyopathy, Dilated 1a Cardiomyopathy Dilated With Conduction Defect 1 Cardiomyopathy, Dilated, Type 1a
Primary Hyperoxaluria	Hyperoxaluria Hyperoxaluria, Primary Oxalosis Primary Oxalosis Congenital Oxaluria D-Glycerate Dehydrogenase Deficiency Glyceric Aciduria Glycolic Aciduria Hepatic Agt Deficiency Oxaluria, Primary Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Primary Oxaluria Hyperoxaluria Primary Primary Hyperoxaluria Type 2 Primary Hyperoxaluria, Type I
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Muscle Tissue Disease
Cortical Dysplasia, Complex, With Other Brain Malformations 6	Complex Cortical Dysplasia With Other Brain Malformations 6 CDCBM6 Cdcbm56 Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6
Limb-Girdle Muscular Dystrophy	Lgmd Limb Girdle Muscular Dystrophy Muscular Dystrophies, Limb-Girdle Erb'S Muscular Dystrophy Leyden-Mbius Muscular Dystrophy Limb-Girdle Syndrome Myopathic Limb-Girdle Syndrome Limb Girdle Muscular Dystrophy Limb-Girdle Dystrophy, Muscular, Limb-Girdle Lgmd - [Limb-Girdle Muscular Dystrophy] Limb Girdle Muscle Dystrophy Limb-Girdle Myopathy
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Myopathy	Muscular Diseases Myopathies
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07715	LMNB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19706	Lmnb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26202	Lmnb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LMNB1	RGD	RGD:620522
Felis catus	LMNB1	VGNC	VGNC:68067
Bos taurus	LMNB1	VGNC	VGNC:30930
Canis familiaris	LMNB1	VGNC	VGNC:42718
Mus musculus	LMNB1	MGD	MGI:96795
Macaca mulatta	LMNB1	VGNC	VGNC:74428
Others	LMNB1	NCBI