lamin B1 Antibody (YA6359)

Cat. No.: HY-P86667: Data Sheet COA
SDS
User Guide for Antibodies
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lamin B1 Antibody (YA6359) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to lamin B1.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

lamin B1 Antibody (YA6359) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to lamin B1.

Host

Rabbit

Clonality

Monoclonal

Molecular Weight

Predicted band size: 70 kDa;

Observed band size: 64 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P20700

Gene ID

4001 [NCBI]

Immunogen

KLH conjugated synthetic peptide derived from human Lamin B1

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-50000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-800
IHC-F IHC-F: Immunohistochemistry-Frozen	1:200-800
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-200
FC FC: Flow Cytometry	1:50-100

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914)

Subcellular Localization：Nucleus lamina

Subunit：Homodimer (PubMed:22265972, PubMed:33706103). Lamin dimers then assemble into dimeric head-to-tail polymers.

Synonyms

LMNB1_HUMAN; Lamin-B1; LMNB1; LMN2; LMNB; LMN; ADLD; MCPH26;

Documentation

Select Batch:

Data Sheet (234 KB) SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)