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ZBED1 - zinc finger BED-type containing 1 Gene

Also Known as ALTE; DREF; TRAMP; hDREF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9189

About ZBED1

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:2,486,435-2,500,976 (from NCBI)

This gene has 6 transcripts (splice variants), 117 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 10.8), colon (RPKM 10.6) and 25 other tissues.

Summary

This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010]

ZBED1 Products (3)

mRNA	Protein	Name
NM_001171135.2	NP_001164606.1	E3 SUMO-protein ligase ZBED1
NM_001171136.2	NP_001164607.1	E3 SUMO-protein ligase ZBED1
NM_004729.4	NP_004720.1	E3 SUMO-protein ligase ZBED1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17220279	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17220279	GOA
enables SUMO ligase activity	IDA IDA: Inferred from direct assay	27068747	GOA
enables SUMO transferase activity	EXP EXP: Inferred from Experiment	27068747	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17209048	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	27068747	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	17209048	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	25210186	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation by host of viral genome replication	IDA IDA: Inferred from direct assay	25210186	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17220279	GOA
involved in protein autosumoylation	IMP IMP: Inferred from mutant phenotype	27068747	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	25210186	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in PML body	IDA IDA: Inferred from direct assay	25210186	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17209048	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBED1 Protein Structure

zf-BED

Dimer_Tnp_hAT

0
200
400
600
694 a.a.

Protein Preferred Names	Protein Names
E3 SUMO-protein ligase ZBED1	Ac-like transposable element

ZBED1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZBED1	O96006	a8k5h9_human	Homo sapiens	A8K5H9	Validated Y2H	25416956
Intra	ZBED1	O96006	a8k5h9_human	Homo sapiens	A8K5H9	Y2H Array	25416956
Intra	ZBED1	O96006	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	25416956
Intra	ZBED1	O96006	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	25416956
Intra	ZBED1	O96006	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	ZBED1	O96006	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	ZBED1	O96006	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	25416956
Intra	ZBED1	O96006	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	ZBED1	O96006	LRRC20	Homo sapiens	Q8TCA0	Validated Y2H	32296183
Intra	ZBED1	O96006	LRRC20	Homo sapiens	Q8TCA0	Y2H Array	25416956
Intra	ZBED1	O96006	GGACT	Homo sapiens	Q9BVM4	Validated Y2H	32296183
Intra	ZBED1	O96006	UCHL5	Homo sapiens	Q9Y5K5	Validated Y2H	25416956
Intra	ZBED1	O96006	UCHL5	Homo sapiens	Q9Y5K5	Y2H Array	25416956
Intra	ZBED1	O96006	UCHL5	Homo sapiens	Q9Y5K5	Y2H Prey Pooling	25416956
Intra	ZBED1	O96006	NCDN	Homo sapiens	Q9UBB6	Validated Y2H	32296183
Intra	ZBED1	O96006	CCDC13	Homo sapiens	Q8IYE1	Validated Y2H	32296183
Intra	ZBED1	O96006	TRIML2	Homo sapiens	Q8N7C3	Validated Y2H	32296183
Intra	ZBED1	O96006	PRKAA1	Homo sapiens	Q13131	Validated Y2H	25416956
Intra	ZBED1	O96006	LCN2	Homo sapiens	P80188	Validated Y2H	32296183
Intra	ZBED1	O96006	TRAPPC2	Homo sapiens	P0DI81-3	Validated Y2H	32296183
Intra	ZBED1	O96006	FAM124B	Homo sapiens	Q9H5Z6-2	Validated Y2H	32296183
Intra	ZBED1	O96006	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	ZBED1	O96006	SSX2	Homo sapiens	Q16385	Validated Y2H	25416956
Intra	ZBED1	O96006	MPST	Homo sapiens	P25325	Validated Y2H	32296183
Intra	ZBED1	O96006	CDC37	Homo sapiens	Q16543	Validated Y2H	32296183
Intra	ZBED1	O96006	PIAS2	Homo sapiens	O75928	Y2H Array	25416956
Intra	ZBED1	O96006	PIAS2	Homo sapiens	O75928	Y2H Prey Pooling	25416956
Intra	ZBED1	O96006	PIAS2	Homo sapiens	O75928	Validated Y2H	25416956
Intra	ZBED1	O96006	RIN1	Homo sapiens	Q13671	Validated Y2H	32296183
Intra	ZBED1	O96006	CTNNAL1	Homo sapiens	Q9UBT7	Validated Y2H	32296183
Intra	ZBED1	O96006	KDM1A	Homo sapiens	O60341	Y2H	21516116
Intra	ZBED1	O96006	POLE2	Homo sapiens	P56282	Validated Y2H	32296183
Intra	ZBED1	O96006	PSAP	Homo sapiens	P07602	Validated Y2H	32296183
Intra	ZBED1	O96006	MKKS	Homo sapiens	Q9NPJ1	Validated Y2H	32296183
Intra	ZBED1	O96006	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	ZBED1	O96006	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	ZBED1	O96006	AIRIM	Homo sapiens	Q9NX04	Y2H Array	25416956
Intra	ZBED1	O96006	EFHC1	Homo sapiens	Q5JVL4	Validated Y2H	32296183
Intra	ZBED1	O96006	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	ZBED1	O96006	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	25416956
Intra	ZBED1	O96006	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	ZBED1	O96006	FNDC11	Homo sapiens	Q9BVV2	Validated Y2H	32296183
Intra	ZBED1	O96006	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	ZBED1	O96006	PAX6	Homo sapiens	P26367	Validated Y2H	32296183
Intra	ZBED1	O96006	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	ZBED1	O96006	MAD2L2	Homo sapiens	Q9UI95	Validated Y2H	32296183
Intra	ZBED1	O96006	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	ZBED1	O96006	TTC23	Homo sapiens	Q5W5X9-3	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ZBED1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71047	ZBED1 Protein, Human (His)	O96006 (N3-E100)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Fibrosclerosis Of Breast	Fibrosis Of The Breast Breast Fibrosis
Sotos Syndrome 1	Sotos1 Sotos Syndrome, Type 1 Sotos' Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15954	ZBED1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown