NCDN - neurochondrin Gene

Also Known as NEDIES

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23154

About NCDN

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:35,557,799-35,566,779 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues and is associated with 4 phenotypes. Biased expression in brain (RPKM 97.7), adrenal (RPKM 7.8) and 6 other tissues.

Summary

This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates CA/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2008]

NCDN Products (3)

mRNA Protein Name
NM_001014839.2 NP_001014839.1 neurochondrin isoform 1
NM_001014841.2 NP_001014841.1 neurochondrin isoform 2
NM_014284.3 NP_055099.1 neurochondrin isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
23687301 GOA
located in membrane IDA
IDA: Inferred from direct assay
23687301 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCDN Protein Structure

Neurochondrin

Neurochondrin: Neurochondrin (30 - 637)

  • 0
  • 200
  • 400
  • 600
  • 729 a.a.
Protein Preferred Names Protein Names

neurochondrin

  • norbin

NCDN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NCDN Q9UBB6 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra
NCDN Q9UBB6 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
25416956
Intra
NCDN Q9UBB6 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra
NCDN Q9UBB6 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra
NCDN Q9UBB6 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra
NCDN Q9UBB6 TINF2 Homo sapiens Q9BSI4
Pull Down
21044950
Intra
NCDN Q9UBB6 ZBED1 Homo sapiens O96006
Y2H Array
32296183
Intra
NCDN Q9UBB6 ZBED1 Homo sapiens O96006
Y2H Prey Pooling
32296183
Intra
NCDN Q9UBB6 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
NCDN Q9UBB6 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
NCDN Q9UBB6 ZNF398 Homo sapiens Q8TD17
Y2H Prey Pooling
32296183
Intra
NCDN Q9UBB6 ZNF398 Homo sapiens Q8TD17
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Infantile Epileptic Spasms

  • NEDIES
Autosomal Recessive Non-Syndromic Intellectual Disability

  • Ar-Nsid

  • Ns-Arid
Aceruloplasminemia

  • Cerebellar Ataxia

  • Hypoceruloplasminemia

  • Hemosiderosis, Systemic, Due To Aceruloplasminemia

  • Familial Apoceruloplasmin Deficiency

  • Hereditary Ceruloplasmin Deficiency

  • Deficiency Of Ferroxidase

  • Hypoceruloplasminemia, Hereditary

  • Ceruloplasmin Deficiency

  • Systemic Hemosiderosis Due To Aceruloplasminemia

  • ACERULOP
Autoimmune Neuropathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09075 NCDN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NCDN VGNC VGNC:31910
Felis catus NCDN VGNC VGNC:63737
Macaca mulatta NCDN VGNC VGNC:74980
Canis familiaris NCDN VGNC VGNC:43648
Mus musculus NCDN MGD MGI:1347351
Rattus norvegicus NCDN RGD RGD:621734
Others NCDN NCBI