Desoxyrhaponticin

Name: Desoxyrhaponticin
Brand: MedChemExpress
SKU: HY-N2486
Rating: 4.5 (1 reviews)

Cat. No.: HY-N2486 Purity: 99.80%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Desoxyrhaponticin is a kind of oral drug that inhibits effective fatty acid synthesis (FASN), and has a fatal effect on cancer cells. Desoxyrhaponticin has the ability to inhibit glucose uptake, improve oral glucose tolerance as a diabetic agent, and possess anti-diabetic effects.

For research use only. We do not sell to patients.

Desoxyrhaponticin Chemical Structure

CAS No. : 30197-14-9

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 130	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 130	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 56	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 119	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 202	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 404	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Desoxyrhaponticin

•Biomed Res Int. 2021 Sep 9;2021:9066938. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

The IC50s values for inhibition of renal membrane vesicle uptake in normal rats and diabetic rats were 118.8 and 115.7 μM, respectively. Desoxyrhaponticin effectively controls hyperglycemia by inhibiting glucose transport in the small intestine and inhibiting glucose reabsorption in the kidneys^[2].
Desoxyrhaponticin inhibits glucose uptake in rabbit intestinal mesangial vesicles and rat everted intestinal cuffs with IC50s of 148.3 and 30.9 μMs, respectively^[2].
Desoxyrhaponticin (500 μM) inhibits glucose uptake into rabbit intestinal brush-border membrane vesicles, IC50=30.9 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Desoxyrhaponticin (150, 300 mg/kg; po; single dose before the glucose loading) inhibits intestinal and renal glucose transport in normal and diabetic rats, and reduces postprandial hyperglycemia in diabetic rat^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

404.41

Formula

C₂₁H₂₄O₈

CAS No.

30197-14-9

Appearance

Solid

Color

White to off-white

SMILES

COC(C=C1)=CC=C1/C=C/C2=CC(O)=CC(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)=C2

Structure Classification

Stilbenes

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (247.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4727 mL	12.3637 mL	24.7274 mL
5 mM	0.4945 mL	2.4727 mL	4.9455 mL
10 mM	0.2473 mL	1.2364 mL	2.4727 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.80%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (247 KB) HNMR (142 KB) RP-HPLC (77 KB)

Handling Instructions (2659 KB)

References

[1]. Li P, et al. Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4727 mL	12.3637 mL	24.7274 mL	61.8185 mL
	5 mM	0.4945 mL	2.4727 mL	4.9455 mL	12.3637 mL
	10 mM	0.2473 mL	1.2364 mL	2.4727 mL	6.1818 mL
	15 mM	0.1648 mL	0.8242 mL	1.6485 mL	4.1212 mL
	20 mM	0.1236 mL	0.6182 mL	1.2364 mL	3.0909 mL
	25 mM	0.0989 mL	0.4945 mL	0.9891 mL	2.4727 mL
	30 mM	0.0824 mL	0.4121 mL	0.8242 mL	2.0606 mL
	40 mM	0.0618 mL	0.3091 mL	0.6182 mL	1.5455 mL
	50 mM	0.0495 mL	0.2473 mL	0.4945 mL	1.2364 mL
	60 mM	0.0412 mL	0.2061 mL	0.4121 mL	1.0303 mL
	80 mM	0.0309 mL	0.1545 mL	0.3091 mL	0.7727 mL
	100 mM	0.0247 mL	0.1236 mL	0.2473 mL	0.6182 mL