Antitumor agent-74
Antitumor agent-74 (compound 13da) is a quinoxalines derivative, an antitumor agent. Antitumor agent-74 exhibits more potent efficacy on tumor inhibition, mixed with regioisomer Antitumor agent-75(HY-151295, compound 14 da) (mriBIQ 13da/14da). mriBIQ 13da/14da attests cell cycle at S phase, inhibits DNA synthesis, and induces mithochondrial apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 2827065-28-9
- Formula: C26H23FN6
- Molecular Weight:438.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Antitumor agent-74 (compound 13da) shows lower cytotoxicity (IC50s=56.7-86.3 μM) against cancer cells than mriBIQ 13da/14da (IC50s=2.8-34.0 μM)[1].
mriBIQ 13da/14da shows high selectivity on A549 cells over normal embryonic lung cells (Wi38), with selectivity index of 12 (IC50 of Wi38/A549)[1].
mriBIQ 13da/14da (1-100 μM; 48 h) inhibtis A549 cells proliferation and decreases the rate of cell division in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:M-HeLa, MCF-7, HuTu-80, PANC-1, A549, PC3, T98G, Wi38 cells
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Concentration:0-100 μM
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Incubation Time:48 hours
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Result:Showed low cytotoxicity and inhibited cancer cells with IC50s of 58.7, 67.3, 75.6, 86.3, 65.6, 63.2, 68.7, and 56.7 μM, respectively.
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Cell Line:A549
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Concentration:mriBIQ 13da/14da: 1, 5, 25, 50, 100 μM
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Incubation Time:48 hours
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Result:Decreased the rate of cell division, associated with induction of apoptosis in A549 cells.
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Cell Line:A549
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Concentration:mriBIQ 13da/14da: 1, 2.5, 5 μM
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Incubation Time:12 hours
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Result:Increased the number of cells in the S-phase at 1, 2.5, and 5 μM of 49.0%, 66.3%, and 68.0%, respectively.
Chemical Information
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CAS No. 2827065-28-9
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Molecular Weight 438.50
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Formula C26H23FN6
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SMILES
CN1CCN(C2=CC=C3N=C(C4=CC=C(F)C=C4)C(C5=NC6=CC=CC=C6N5)=NC3=C2)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-74 Related Classifications
HY-151292 Related Classifications
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