Cimetidine hydrochloride
Based on 6 publication(s) in Google Scholar
Cimetidine (SKF-92334) hydrochloride is an orally active, inverse and BBB-permeable histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine hydrochloride is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine hydrochloride has anti-cancer and anti-inflammatory activity.
For research use only. We do not sell to patients.
- CAS No.: 70059-30-2
- Formula: C10H17ClN6S
- Molecular Weight:288.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Cimetidine hydrochloride
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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Cell Migration/Invasion Assay
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Cell Migration/Invasion Assay
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WB
All Histamine Receptor Isoforms
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Biological Activity
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H2 Receptor .6 μM (Kd) |
Cimetidine (SKF-92334) hydrochloride, a partial agonist for H2R, has a pharmacological profile different from ranitidine and famotidine, possibly contributing to its antitumor activity on gastrointestinal cancers [1]. Cimetidine hydrochloride has no effect on the uptake and cytotoxicity of cisplatin in ovarian cancer cells with high OCT2 mRNA levels (IGROV-1 cells)[3].
Cimetidine hydrochloride shows no effect on proliferation, survival, migration and invasion of 3LL cells. Cimetidine hydrochloride reverses MDSC-mediated T-cell suppression, and improves IFN-γ production[4].
Cimetidine-mediated down-regulation of NCAM involved suppression of the nuclear translocation of NF-kappaB, a transcriptional activator of NCAM gene expression[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Cimetidine hydrochloride exerts a beneficial effect on periodontal disease in rats, decreasing the RANKL/OPG ratio in gingival connective tissue and reducing alveolar bone resorption[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 70059-30-2
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Molecular Weight 288.80
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Formula C10H17ClN6S
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SMILES
CC1=C(CSCC/N=C(NC)/NC#N)NC=N1.[H]Cl
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Synonyms
SKF-92334 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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Biochim Biophys Acta Mol Basis Dis
Both carvedilol and cimetidine alleviate cisplatin-induced nephrotoxicity via downregulating OCT2. [Abstract]2025 Jun;1871(5):167754. PMID: 40044066 -
Exp Neurol
Inhibition of histamine receptor 3 alleviates sevoflurane-induced hypomyelination and neurobehavioral deficits. [Abstract]2025 Mar:385:115086. PMID: 39637962 -
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Ann Transl Med
Cimetidine promotes STUB1-mediated degradation of tumoral FOXP3 by activating PI3K-Akt pathway in gastric cancer. [Abstract]2020 Oct;8(20):1304. PMID: 33209884
Cimetidine hydrochloride purchased from MedChemExpress. Usage Cited in: Ann Transl Med. 2020 Oct;8(20):1304. [Abstract]
Our study showed that Cimetidine disrupted the proliferative capacity of GC cells by CCK8.
Cimetidine hydrochloride purchased from MedChemExpress. Usage Cited in: Ann Transl Med. 2020 Oct;8(20):1304. [Abstract]
Our study showed that Cimetidine (4 mM, 24 h) disrupted the proliferative capacity of GC cells byplate clone assay.
Cimetidine hydrochloride purchased from MedChemExpress. Usage Cited in: Ann Transl Med. 2020 Oct;8(20):1304. [Abstract]
Wound healing showed that Cimetidine (4 mM, 24 h) significantly reduced the number of migrated GC cells.
Cimetidine hydrochloride purchased from MedChemExpress. Usage Cited in: Ann Transl Med. 2020 Oct;8(20):1304. [Abstract]
Transwell assay showed that Cimetidine (4 mM, 24 h) significantly reduced the number of migrated GC cells.
Cimetidine hydrochloride purchased from MedChemExpress. Usage Cited in: Ann Transl Med. 2020 Oct;8(20):1304. [Abstract]
CCK8 assay revealed that the IC50 of Cimetidine (0-10 mM) inhibiting the viability of GC cells was increased with the decrease of FOXP3 level in these GC cells.
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Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299
Purity & Documentation
References
[1]. M J Smit, et al. Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6802-7. [Content Brief]
[2]. Takahashi, H.K., et al., Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol, 2006. 70(2): p. 450-3. [Content Brief]
[3]. Sprowl, J.A., et al., Conjunctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemic clearance. Clin Pharmacol Ther, 2013. 94(5): p. 585-92. [Content Brief]
[4]. Zheng, Y., et al., Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. Mol Immunol, 2013. 54(1): p. 74-83. [Content Brief]
[5]. Fukuda, M., K. Kusama, and H. Sakashita, Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression. BMC Cancer, 2008. 8: p. 376. [Content Brief]
[6]. Longhini, R., et al., Cimetidine Reduces the Alveolar Bone Loss in Induced Periodontitis in Rat Molars. J Periodontol, 2013. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cimetidine hydrochloride Related Classifications
HY-14289A Related Classifications
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