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U2AF2 - U2 small nuclear RNA auxiliary factor 2 Gene

Also Known as U2AF65

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11338

About U2AF2

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,655,035-55,674,716 (from NCBI)

This gene has 7 transcripts (splice variants), 233 orthologues, 5 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 33.5), appendix (RPKM 33.2) and 25 other tissues.

Summary

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]

U2AF2 Products (2)

mRNA	Protein	Name
NM_001012478.2	NP_001012496.1	splicing factor U2AF 65 kDa subunit isoform b
NM_007279.3	NP_009210.1	splicing factor U2AF 65 kDa subunit isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	19574390	GOA
enables molecular function inhibitor activity	EXP EXP: Inferred from Experiment	32188783	GOA
enables pre-mRNA 3'-splice site binding	IDA IDA: Inferred from direct assay	2531895	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9237760	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	1824937	GOA
involved in negative regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	15009664	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	24389012	GOA
involved in negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	24389012	GOA
involved in positive regulation of RNA splicing	IDA IDA: Inferred from direct assay	21536736	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Prp19 complex	IDA IDA: Inferred from direct assay	21536736	GOA
part of U2-type prespliceosome	IDA IDA: Inferred from direct assay	2531895	GOA
part of U2AF complex	IDA IDA: Inferred from direct assay	1824937	GOA
part of U2AF complex	IPI IPI: Inferred from physical interaction	11551507	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	1824937	GOA
located in nucleus	IDA IDA: Inferred from direct assay	1824937	GOA
part of spliceosomal complex	IDA IDA: Inferred from direct assay	9731529	GOA
part of spliceosomal complex	IPI IPI: Inferred from physical interaction	11551507	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

U2AF2 Protein Structure

RRM_1

0
100
200
300
400
475 a.a.

Protein Preferred Names	Protein Names
splicing factor U2AF 65 kDa subunit	U2 (RNU2) small nuclear RNA auxiliary factor 2

U2AF2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	U2AF2	P26368	DACH1	Homo sapiens	Q9UI36-2	Validated Y2H	25416956
Intra	U2AF2	P26368	DACH1	Homo sapiens	Q9UI36-2	Y2H Array	25416956
Intra	U2AF2	P26368	PUF60	Homo sapiens	Q9UHX1	Y2H Pooling	16189514
Intra	U2AF2	P26368	CHERP	Homo sapiens	Q8IWX8	Y2H	22365833
Intra	U2AF2	P26368	SUGP1	Homo sapiens	Q8IWZ8	Anti Tag CoIP	22365833
Intra	U2AF2	P26368	SCAF11	Homo sapiens	Q99590	Anti Tag CoIP	33961781
Intra	U2AF2	P26368	SCAF11	Homo sapiens	Q99590	Y2H	21988832
Intra	U2AF2	P26368	SRSF1	Homo sapiens	Q07955	Anti Tag CoIP	33961781
Intra	U2AF2	P26368	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
Intra	U2AF2	P26368	SNRPA	Homo sapiens	P09012	Y2H	22365833
Intra	U2AF2	P26368	SNRPA	Homo sapiens	P09012	Y2H Prey Pooling	25416956
Intra	U2AF2	P26368	SNRPA	Homo sapiens	P09012	Y2H Array	25416956
Intra	U2AF2	P26368	U2AF1	Homo sapiens	Q01081	Y2H	21988832
Intra	U2AF2	P26368	U2AF1	Homo sapiens	Q01081	Y2H Prey Pooling	25416956
Intra	U2AF2	P26368	U2AF1	Homo sapiens	Q01081	Pull Down	21460037
Intra	U2AF2	P26368	U2AF1	Homo sapiens	Q01081	Anti Tag CoIP	35271311
Intra	U2AF2	P26368	U2AF1	Homo sapiens	Q01081	Anti Bait CoIP	21460037
Intra	U2AF2	P26368	U2AF1	Homo sapiens	Q01081	X-Ray Diffraction	11551507
Intra	U2AF2	P26368	U2AF1	Homo sapiens	Q01081	Y2H Array	25416956
Intra	U2AF2	P26368	U2AF1	Homo sapiens	Q01081	Y2H	21516116
Intra	U2AF2	P26368	U2AF1	Homo sapiens	Q01081	Anti Tag CoIP	33961781
Intra	U2AF2	P26368	SNW1	Homo sapiens	Q13573	Pull Down	21460037
Intra	U2AF2	P26368	SNW1	Homo sapiens	Q13573	Anti Bait CoIP	21460037
Intra	U2AF2	P26368	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	U2AF2	P26368	RBM10	Homo sapiens	P98175	Anti Tag CoIP	35271311
Intra	U2AF2	P26368	RBM10	Homo sapiens	P98175	Anti Tag CoIP	22365833
Intra	U2AF2	P26368	THAP1	Homo sapiens	Q9NVV9	Y2H Array	25416956
Intra	U2AF2	P26368	THAP1	Homo sapiens	Q9NVV9	Y2H Pooling	16189514
Intra	U2AF2	P26368	PRPF3	Homo sapiens	O43395	Anti Tag CoIP	22365833
Intra	U2AF2	P26368	PRPF3	Homo sapiens	O43395	Anti Tag CoIP	35271311
Intra	U2AF2	P26368	SF1	Homo sapiens	Q15637	Pull Down	26420826
Intra	U2AF2	P26368	SF1	Homo sapiens	Q15637	Pull Down	12718882
Intra	U2AF2	P26368	SF1	Homo sapiens	Q15637	Y2H Fragment Pooling	26420826
Intra	U2AF2	P26368	SF1	Homo sapiens	Q15637	Anti Tag CoIP	35271311
Intra	U2AF2	P26368	ATXN1	Homo sapiens	P54253	Y2H Array	16713569

Cross: Cross-species interaction Intra: Intraspecies interaction

U2AF2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82476	U2AF2 Antibody (YA2221)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia 1	Spinocerebellar Ataxia Type 1 SCA1 Olivopontocerebellar Atrophy I Opca1 Opca4 Menzel Type Opca Schut-Haymaker Type Opca Spinocerebellar Atrophy I Opca I Olivopontocerebellar Atrophy Iv Opca Iv Cerebelloparenchymal Disorder I Cpd1 Olivopontocerebellar Atrophy 1 Cerebelloparenchymal Disorder 1 Olivopontocerebellar Atrophy 4 Spinocerebellar Atrophy 1 Type 1 Spinocerebellar Ataxia Spinocerebellar Ataxia-1 Ataxia, Spinocerebellar, Type 1
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153736	NSC 194308		99.86%	Unkown
HY-RS15314	U2AF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22890	U2af2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29404	U2af2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	U2AF2	RGD	RGD:1310690
Felis catus	U2AF2	VGNC	VGNC:66741
Canis familiaris	U2AF2	VGNC	VGNC:48032
Bos taurus	U2AF2	VGNC	VGNC:36556
Mus musculus	U2AF2	MGD	MGI:98886
Others	U2AF2	NCBI