S100A9 - S100 calcium binding protein A9 Gene

Also Known as MIF; NIF; P14; CAGB; CFAG; CGLB; L1AG; LIAG; MRP14; 60B8AG; MAC387; S100-A9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6280

About S100A9

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,357,854-153,361,023 (from NCBI)

This gene has 1 transcript (splice variant), 344 orthologues and 21 paralogues. Biased expression in bone marrow (RPKM 7440.5), esophagus (RPKM 5956.4) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of Casein Kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits Antifungal and Antibacterial activity. [provided by RefSeq, Nov 2014]

S100A9 Products (1)

mRNA	Protein	Name
NM_002965.4	NP_002956.1	protein S100-A9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9867828	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	19935772	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12874352	GOA
involved in autophagy	IDA IDA: Inferred from direct assay	19935772	GOA
involved in leukocyte migration involved in inflammatory response	IDA IDA: Inferred from direct assay	12626582	GOA
involved in modulation of process of another organism	IDA IDA: Inferred from direct assay	12874352	GOA
involved in neutrophil aggregation	IDA IDA: Inferred from direct assay	12626582	GOA
involved in neutrophil chemotaxis	IDA IDA: Inferred from direct assay	12626582	GOA
involved in peptidyl-cysteine S-trans-nitrosylation	IDA IDA: Inferred from direct assay	25417112	GOA
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	12626582	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	19935772	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of S100A9 complex	IPI IPI: Inferred from physical interaction	11851337	GOA
part of calprotectin complex	IPI IPI: Inferred from physical interaction	25597447	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12874352	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	21805676	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A9 Protein Structure

S_100

0
100
114 a.a.

Protein Preferred Names	Protein Names
protein S100-A9	MRP-14

S100A9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	S100A9	P06702	MAGEA6	Homo sapiens	P43360	Validated Y2H	32296183
Intra	S100A9	P06702	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
Intra	S100A9	P06702	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
Intra	S100A9	P06702	S100A8	Homo sapiens	P05109	Y2H	9867828
Intra	S100A9	P06702	S100A8	Homo sapiens	P05109	Anti Tag CoIP	25417112
Intra	S100A9	P06702	S100A8	Homo sapiens	P05109	Y2H Pooling	20936779
Intra	S100A9	P06702	S100A8	Homo sapiens	P05109	Anti Bait CoIP	25417112
Intra	S100A9	P06702	S100B	Homo sapiens	P04271	Y2H Prey Pooling	32296183
Intra	S100A9	P06702	S100B	Homo sapiens	P04271	Y2H Array	32296183
Intra	S100A9	P06702	MAGEA3	Homo sapiens	P43357	Validated Y2H	32296183
Intra	S100A9	P06702	MAGEA3	Homo sapiens	P43357	Y2H Array	32296183
Intra	S100A9	P06702	MAGEA3	Homo sapiens	P43357	Y2H Prey Pooling	32296183
Intra	S100A9	P06702	ARRB2	Homo sapiens	P32121	Anti Tag CoIP	17620599
Intra	S100A9	P06702	MAGEA1	Homo sapiens	P43355	Validated Y2H	32296183
Intra	S100A9	P06702	MAGEA1	Homo sapiens	P43355	Y2H Array	32296183
Intra	S100A9	P06702	MAGEA1	Homo sapiens	P43355	Y2H Prey Pooling	32296183
Intra	S100A9	P06702	ARRB1	Homo sapiens	P49407	Anti Tag CoIP	17620599

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70532	S100A9 Protein, Human	P06702 (T2-P114)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71076	S100A8-S100A9 Heterodimer Protein, Human (His, solution)	P05109 (M1-E93) (S100A8)&P06702 (T2-P114) (S100A9)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76587	S100A9 Protein, Human (sf9, His)	P06702 (M1-P114)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70532A	S100A9 Protein, Human (His)	P06702 (T2-P114)	≥ 95%, as determined by reducing SDS-PAGE.

S100A9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83734	S100A9 Antibody(YA3464)	WB, IHC-P, IF-Tissue, mIHC	Human
HY-P83974	S100A9 Antibody (YA3671)	IHC-P, FC, ELISA	Human
HY-P83974A	S100A9 Antibody (YA3671)(PBS only)	IHC-P, FC, ELISA	Human
HY-P85718	S100 A8+A9 Antibody (YA5410)	IHC-P	Human

Related Diseases

Diseases	Alias
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Juvenile Rheumatoid Arthritis	Juvenile Idiopathic Arthritis Juvenile Chronic Polyarthritis Monarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Arthritis Still'S Disease Systemic Juvenile Rheumatoid Arthritis Juvenile Chronic Arthritis Acute Juvenile Rheumatoid Arthritis Pauciarticular Onset Juvenile Chronic Arthritis Arthritis, Juvenile Rheumatoid Jia Jra Juvenile Ra Arthritis Juvenile Rheumatoid Stills Disease Juvenile Arthritis Acute Polyarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Rheumatoid Arthritis Rheumatoid Arthritis, Systemic Juvenile
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Erythema Elevatum Diutinum
Fibroma
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Psoriasis
Pouchitis
Appendicitis	Acute Appendicitis Acute Appendicitis With Generalized Peritonitis Acute Appendicitis Nos Acute Appendicitis With Peritoneal Abscess Appendiceal Inflammation Appendicitis, Unqualified Acute Appendix Inflammation Acute Appendicitis With Diffuse Peritonitis Following Rupture Or Perforation Acute Appendicitis With Free Peritonitis Acute Appendicitis With Free Perforation To The Abdominal Cavity Perforated Appendix With Generalised Peritonitis Appendicitis With Perforation And Free Pus In The Peritoneal Cavity Perforated Appendix With Localised Peritonitis Acute Appendicitis With Contained Perforation To A Localised Abscess Acute Appendicitis With Localised Peritonitis With Rupture Or Perforation Acute Appendicitis With Localised Peritonitis Without Rupture Or Perforation Acute Appendicitis With Perforation And Contained Peritonitis Into An Abscess Appendicitis With Abscess Appendicitis With Peritoneal Abscess Ruptured Appendix Nos Acute Appendicitis With No Perforation Or Abscess And No Visible Pus Acute Appendicitis With No Specification If Perforated Or Not Acute Appendicitis With Phlegmone
Renal Infectious Disease
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Vasculitis	Angiitis Autoimmune Vasculitis Systemic Vasculitis Vasculitis, Autoimmune
Gout	Gouty Arthritis Articular Gout Gouty Arthropathy Arthritis, Gouty Arthritis Gouty Idiopathic Gout Idiopathic Gout, Unspecified Site Gouty Bursitis Uratic Arthritis Gout Nos Gouty Gouty Diathesis
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Kawasaki Disease	Mucocutaneous Lymph Node Syndrome Acute Febrile Mucocutaneous Lymph Node Syndrome Kawasaki Syndrome Kd Infantile Polyarteritis Kawasaki Disease, Susceptibility To Acute Febrile Mcls Kawasaki'S Disease Mlns KWD
Nodular Tenosynovitis	Synovioma, Benign Benign Synovioma Benign Tumor Of Synovium Localized Giant Cell Tumor Of Tenosynovium Giant Cell Tumor Of Tendon Sheath
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Diverticulitis
Multicentric Reticulohistiocytosis	Lipoid Dermatoarthritis Giant Cell Histiocytomatosis
Sexual Sadism	Sadism
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Spondylarthropathy	Spondylarthropathies
Congenital Epulis	Gingival Neoplasms Congenital Epulides Congenital Gingival Cell Tumor Congenital Granular Cell Tumor Neumann Tumor
Sarcoidosis 1	Sarcoidosis Boeck Sarcoid Besnier-Boeck-Schaumann Disease SS1 Sarcoidosis, Susceptibility To, 1 Lymphogranulomatosis Hodgkin Disease Boeck'S Disease Boeck'S Sarcoid Schaumann'S Disease Or Syndrome Hutchinson-Boeck Disease Or Syndrome
Omsk Hemorrhagic Fever	Ohf Hemorrhagic Fever, Omsk Ohf - [Omsk Haemorrhagic Fever] Spring-Fall Haemorrhagic Fever
Congenital Granular Cell Tumor
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10528	Tasquinimod	Modulator	99.70%	Phase 3
HY-100442	Paquinimod	Inhibitor	99.90%	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100442S1	Paquinimod-d5-1	Inhibitor	98.19%	Unkown
HY-10528S	Tasquinimod-d3	Modulator	99.34%	Unkown
HY-RS12386	S100A9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16579	S100a9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-178053	AHR agonist 10		/	Unkown
HY-181576	ROCK2-IN-14	Inhibitor	/	Unkown
HY-100442S	Paquinimod-d5	Inhibitor	/	Unkown
HY-RS23013	S100a9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991517	BI-836858		95.81%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	S100A9	RGD	RGD:620267
Mus musculus	S100A9	MGD	MGI:1338947
Bos taurus	S100A9	VGNC	VGNC:34247
Macaca mulatta	S100A9	VGNC	VGNC:76961
Felis catus	S100A9	VGNC	VGNC:64843
Others	S100A9	NCBI