2. Anti-infection Others
  3. Isotope-Labeled Compounds SARS-CoV
  4. Paquinimod-d5-1

Paquinimod-d5-1  (Synonyms: ABR-215757-d5-1; ABR 25757-d5-1)

Cat. No.: HY-100442S1 Purity: 98.19%
COA Handling Instructions

Molarity Calculator

Paquinimod-d5-1 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice.

For research use only. We do not sell to patients.

Paquinimod-d<sub>5</sub>-1 Chemical Structure

Paquinimod-d5-1 Chemical Structure

Size Price Stock Quantity
1 mg USD 480 In-stock
5 mg USD 1200 In-stock
10 mg USD 2050 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Paquinimod-d5-1 Related Antibodies

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Description

Paquinimod-d5-1 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice[1][2][3].

Molecular Weight

355.44

Formula

C21H17D5N2O3
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])CC)C2=C(C3=C(N(C2=O)C)C=CC=C3CC)O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (281.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8134 mL 14.0671 mL 28.1341 mL
5 mM 0.5627 mL 2.8134 mL 5.6268 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8134 mL 14.0671 mL 28.1341 mL 70.3354 mL
5 mM 0.5627 mL 2.8134 mL 5.6268 mL 14.0671 mL
10 mM 0.2813 mL 1.4067 mL 2.8134 mL 7.0335 mL
15 mM 0.1876 mL 0.9378 mL 1.8756 mL 4.6890 mL
20 mM 0.1407 mL 0.7034 mL 1.4067 mL 3.5168 mL
25 mM 0.1125 mL 0.5627 mL 1.1254 mL 2.8134 mL
30 mM 0.0938 mL 0.4689 mL 0.9378 mL 2.3445 mL
40 mM 0.0703 mL 0.3517 mL 0.7034 mL 1.7584 mL
50 mM 0.0563 mL 0.2813 mL 0.5627 mL 1.4067 mL
60 mM 0.0469 mL 0.2345 mL 0.4689 mL 1.1723 mL
80 mM 0.0352 mL 0.1758 mL 0.3517 mL 0.8792 mL
100 mM 0.0281 mL 0.1407 mL 0.2813 mL 0.7034 mL
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Paquinimod-d5-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Paquinimod-d5-1ABR-215757-d5-1 ABR 25757-d5-1Isotope-Labeled CompoundsSARS-CoVSARS coronavirusSARS-CoV-2deuterated compoundCOVID-19pneumoniaInhibitorinhibitorinhibit

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