(Rac)-Lateritin
(Rac)-Lateritin is an acyl-CoA:cholesterol acyltransferase (ACAT/SOAT) inhibitor, with IC50 values of 5.7 μM and 5.6 μM in rat liver, respectively. (Rac)-Lateritin exerts time-dependent irreversible enzyme inhibition that persists even after microsomal washing. (Rac)-Lateritin inhibits cholesterol ester formation in macrophages without altering triglyceride synthesis or other steps in oxidized low-density lipoprotein metabolism. (Rac)-Lateritin inhibits the growth of cancer cells, Gram-positive bacteria, and Candida albicans. (Rac)-Lateritin can be used in studies related to atherosclerosis, human solid tumors, mouse lymphocytic leukemia, as well as fungal and bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 2180287-51-6
- Formula: C15H19NO3
- Molecular Weight:261.32
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
ACAT 5.7 μM (IC50) |
SOAT 5.6 μM (IC50) |
(Rac)-Lateritin irreversibly (compound 103) inhibits SOAT activity in rat liver microsomes with an IC50 of 5.6 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2180287-51-6
-
Molecular Weight 261.32
-
Formula C15H19NO3
-
SMILES
O=C1OC(C(=O)N(C)C1CC=2C=CC=CC2)C(C)C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hasumi K, et al. Lateritin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Gibberella lateritium IFO 7188. The Journal of antibiotics. 1993 Dec;46(12):1782-7. [Content Brief]
[2]. Bhattacharjee P, et al. Targeting Sterol -Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential. Journal of medicinal chemistry. 2022 Dec 22;65(24):16062-16098. [Content Brief]
[3]. Pettit RK, et al. Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture. Planta medica. 2010 Mar;76(5):500-1. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-Lateritin Related Classifications
HY-121407A Related Classifications
Powered by Bioz