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EG1 

Cat. No.: HY-124838 Purity: 98.03%
Handling Instructions

EG1, a specific Pax2 inhibitor, directly binds the paired domain of Pax2 (Kd=1.35-1.5 μM) and inhibits Pax2-DNA interactions. EG1 can inhibit embryonic kidney development, a process directly dependent on Pax2 activity.

For research use only. We do not sell to patients.

EG1 Chemical Structure

EG1 Chemical Structure

CAS No. : 693241-54-2

Size Price Stock Quantity
25 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 820 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

EG1, a specific Pax2 inhibitor, directly binds the paired domain of Pax2 (Kd=1.35-1.5 μM) and inhibits Pax2-DNA interactions. EG1 can inhibit embryonic kidney development, a process directly dependent on Pax2 activity[1].

In Vitro

EG1 (0-12.5 μM; 48 hours) decreases viability in Pax2 positive renal cancer cell lines[1].
EG1 (0-500 μM) is capable of inhibiting Pax2 mediated expression of EGFP without significant effects on Pax2 protein levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Pax2 positive: a renal cell carcinoma line (RCC111), two ovarian carcinoma cell lines (TOV112D and ES-2); Pax2 negative: prostate cell lines 22Rv1, PC3 or the ovarian cancer cell line SK-OV-3
Concentration: 0, 12.5, 25 μM
Incubation Time: 48 hours
Result: All Pax2 positive cells exhibited a significant decrease in cell viability, whereas none of the Pax2 negative cells were affected.
Molecular Weight

390.39

Formula

C₂₂H₁₈N₂O₅

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (213.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5615 mL 12.8077 mL 25.6154 mL
5 mM 0.5123 mL 2.5615 mL 5.1231 mL
10 mM 0.2562 mL 1.2808 mL 2.5615 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (5.33 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.33 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
EG1
Cat. No.:
HY-124838
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