Cat. No.: HY-N2542

Tubeimoside III

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Tubeimoside III is a triterpenoid saponin. Tubeimoside III has anti-inflammatory and antitumor effects. Tubeimoside III has an LD₅₀ of 15 mg/kg by intraperitoneal injection in ICR mice. Tubeimoside III can be used for the research of tumors and inflammatory diseases.

For research use only. We do not sell to patients.

Purity: 99.91%
CAS No.: 115810-13-4
Formula: C₆₄H₁₀₀O₃₁
Molecular Weight:1365.46

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Tubeimoside III Chemical Structure

CAS No.: 115810-13-4

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

IL-6

IL-1β

All Interleukin Related Isoforms :

All NO Synthase Isoforms :

In Vitro

Tubeimoside III (4 μM; 0-15 h) inhibits NO production, reduces the expression levels of inflammatory factors, suppresses glycolysis and mitochondrial respiration, and increases pyruvate content in LPS (HY-D1056)-induced RAW264.7 cells. The mechanism involves the ATF3-IκBζ pathway and is independent of the NF-κB pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

RAW264.7 treated LPS (HY-D1056)
Concentration:

4 μM
Incubation Time:

Pretreated with 3 h, then co-incubation for 0, 6, and 12 h
Result:

Inhibited the mRNA levels of IL-1β, IL-6 and iNOS, but had no significant effect on the expression of TNF-α.

Western Blot Analysis^[1]

Cell Line:

RAW264.7 treated LPS (HY-D1056)
Concentration:

4 μM
Incubation Time:

Pretreated with 3 h, then co-incubation for 0, 1, and 4 h
Result:

Inhibited the level of IκBζ and increased the level of ATF3.

In Vivo

Tubeimoside III (1 mg/kg; intraperitoneal injection; single dose) exhibits anti-inflammatory activity in a LPS (HY-D1056)-induced acute inflammation mouse model^[1].
Tubeimoside III (0.0075-0.11 μM; topical administration; single dose) shows anti-inflammatory activity by inhibiting ear edema in a TPA (HY-18739)-induced mouse ear edema model^[2].
Tubeimoside III (12 mg/kg; intramuscular injection; 1-3 days) possesses antitumor activity in mice inoculated with S₁₈₀ sarcoma cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57BL/6 mice aged 7-10 weeks old (20-25 g) treated LPS (HY-D1056)^[1]
Dosage:

1 mg/kg
Administration:

Intraperitoneal injection (i.p.); single dose: 3 hours before LPS modeling
Result:

Significantly attenuated splenic congestion, inhibited inflammatory cell infiltration in alveoli, prevented necrosis in liver lesions.
Reduced the mRNA and protein expression levels of inflammatory cytokines IL-6, IL-1β, and iNOS in lung and liver tissues.

Animal Model:

BALB/c mice treated S₁₈₀ sarcoma cells^[2]
Dosage:

12 mg/kg
Administration:

Intramuscular injection (i.m.); 1, 2 and 3 days
Result:

Reduced the tumor weight, with inhibition rates of 36.0%, 65.6% and 72.8% for 1 day, 2 days and 3 days administrations, respectively.

Chemical Information

CAS No. 115810-13-4
Appearance Solid
Molecular Weight 1365.46
Formula C₆₄H₁₀₀O₃₁
Color White to off-white
SMILES

O[C@H]1[C@@]23[C@](CC(C)(C)CC3)([H])C4=CC[C@@]([C@@]5([C@H]([C@@](C)([C@@H](O[C@@]6([H])[C@]([C@H]([C@H](O)[C@@H](CO)O6)O)([H])O[C@]7([H])O[C@@](COC(C[C@](C)(O)CC(O[C@]8([H])[C@@H](O[C@@]9([H])[C@@H]([C@H]([C@H](O)CO9)O)O)[C@@H](O)[C@](O[C@H]8C)([H])O[C@@]%10([H])[C@](OC[C@H](O)[C@@H]%10O)([H])OC2=O)=O)=O)([H])[C@@H](O)[C@H](O)[C@H]7O)[C@@H](O)C5)CO)CC%11)C)([H])[C@]%11(C)[C@]4(C)C1
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Journal Impact Factor

Cell

Molecular characterization of Ebola virus glycoprotein V75A substitution in the 2018-2020 epidemic. [Abstract]

2026 Feb 5;189(3):818-831.e19. PMID: 41576953
Res Sq

A pH-driven receptor switch from ACE2 to NPC1 enables endosomal entry of SARS-CoV-2. [Abstract]

2026 Mar 4:rs.3.rs-8437418. PMID: 41858825

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (73.24 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.7324 mL

3.6618 mL

7.3235 mL

5 mM

0.1465 mL

0.7324 mL

1.4647 mL

10 mM

0.0732 mL

0.3662 mL

0.7324 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

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Volume

Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (289 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li WH, et al. Tubeimoside III inhibits lipopolysaccharide-induced inflammatory responses by reprogramming glycolytic metabolism. Authorea Preprints. 2024.

[2]. Yu TX, et al. Structure-activity relationship of tubeimosides in anti-inflammatory, antitumor, and antitumor-promoting effects. Acta Pharmacol Sin. 2001 May;22(5):463-8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.7324 mL	3.6618 mL	7.3235 mL	18.3088 mL
	5 mM	0.1465 mL	0.7324 mL	1.4647 mL	3.6618 mL
	10 mM	0.0732 mL	0.3662 mL	0.7324 mL	1.8309 mL
	15 mM	0.0488 mL	0.2441 mL	0.4882 mL	1.2206 mL
	20 mM	0.0366 mL	0.1831 mL	0.3662 mL	0.9154 mL
	25 mM	0.0293 mL	0.1465 mL	0.2929 mL	0.7324 mL
	30 mM	0.0244 mL	0.1221 mL	0.2441 mL	0.6103 mL
	40 mM	0.0183 mL	0.0915 mL	0.1831 mL	0.4577 mL
	50 mM	0.0146 mL	0.0732 mL	0.1465 mL	0.3662 mL
	60 mM	0.0122 mL	0.0610 mL	0.1221 mL	0.3051 mL

Keywords

Tubeimoside III

2 Cited Publications

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Tubeimoside III

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Publications Citing Use of MedChemExpress (MCE) Tubeimoside III

All Interleukin Related Isoforms

All NO Synthase Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Tubeimoside III Related Classifications

Cat. No.: HY-N2542