Sotigalimab
Based on 1 Customer Validation
Sotigalimab, a CD40 agonistic monoclonal antibody. Sotigalimab binds CD40 with high affinity and activates antigen-presenting cells, thereby stimulating cancer-specific T cell responses. Sotigalimab is mainly used in the study of metastatic pancreatic cancer and metastatic melanoma.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.90%
- No. CAS: 2305607-45-6
- Peso molecular:144.54 kDa
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas TNF Receptor
More
Actividad biológica
Human IgG1 kappa
Human
TNFRSF5/CD40
Sotigalimab (0-100 nM, 48 h) increases the expression of immune co-stimulatory molecules CD86 and MHC II; thereby increasing the expression of HLA-DR in human primary B cells[3].
Sotigalimab (0-100 nM, 5 days) promote T cell responses, stimulates the T cell proliferation and IFN-γ secretion[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Human CD8 T cell
-
Concentration:0-10 nM
-
Incubation Time:5 days
-
Result:Promoted the proliferation of tumor-infiltrating T cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Cynomolgus monkey models[3]
-
Dosage:0.3-30 mg/kg
-
Administration:iv, once weekly for 4 weeks
-
Result:Reduced the number of peripheral B lymphocytes within 24 hours after administration.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
Human IgG1 kappa
ELISA, FACS, Functional assay
-
Flow Cytometry analysis of Raji cells labelling TNFRSF5/CD40 (red) with Sotigalimab (anti-TNFRSF5/CD40) (HY-P99049). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
-
No. CAS 2305607-45-6
-
Appearance Liquid
-
Peso molecular 144.54 kDa
-
Color Colorless to light yellow
-
SMILES
[Sotigalimab]
-
Synonyms
APX005M; APX005M; EPI-0050
-
Envío
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
-
Ficha de datos (260 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Inhibitory Antibodies User Guide (603 KB)
Referencias
[1]. Mark H O'Hara, et al. CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an open-label, multicentre, phase 1b study. Lancet Oncol. 2021 Jan;22(1) [Content Brief]
[2]. Weiss SA, et al. A Phase II Trial of the CD40 Agonistic Antibody Sotigalimab (APX005M) in Combination with Nivolumab in Subjects with Metastatic Melanoma with Confirmed Disease Progression on Anti-PD-1 Therapy. Clin Cancer Res. 2024 Jan 5;30(1):74-81. [Content Brief]
[3]. Filbert EL, et al., APX005M, a CD40 agonist antibody with unique epitope specificity and Fc receptor binding profile for optimal therapeutic application. Cancer Immunol Immunother. 2021 Jul;70(7):1853-1865. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sotigalimab Related Classifications
HY-P99049 Related Classifications
Powered by Bioz