2. GPCR/G Protein
  3. Vasopressin Receptor
  4. Fedovapagon

Fedovapagon  (Synonyms: VA106483)

Cat. No.: HY-14887 Purity: 99.14%
COA Handling Instructions

Fedovapagon (VA106483) is a selective and orally active vasopressin V2 receptor (V2R) agonist with an EC50 of 24 nM. Fedovapagon can be used in the research of nocturia.

For research use only. We do not sell to patients.

Fedovapagon Chemical Structure

Fedovapagon Chemical Structure

CAS No. : 347887-36-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 154 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 154 In-stock
Solid
5 mg USD 140 In-stock
10 mg USD 220 In-stock
50 mg USD 850 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Fedovapagon Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Fedovapagon (VA106483) is a selective and orally active vasopressin V2 receptor (V2R) agonist with an EC50 of 24 nM. Fedovapagon can be used in the research of nocturia[1].

IC50 & Target[1]

V2 Receptor 

 

V2 Receptor 

24 nM (EC50)

In Vivo

Fedovapagon (1 mg/kg, oral administration) inhibits urine output with 81% inhibition rate in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Brattleboro rats[1]
Dosage: 1 mg/kg, 3 mg/kg
Administration: Oral administration
Result: Reduced urine volume with almost full inhibition of urine output for 2 h.
Returned the urine to normal levels 5 h after dosing.
Clinical Trial
Molecular Weight

462.58

Appearance

Solid

Formula

C27H34N4O3
CAS No.
SMILES

CC1=C(CNC(N2CCC[C@]2(C(N(C)C)=O)[H])=O)C=CC(C(N3CCCCC4=C3C=CC=C4)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (270.22 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1618 mL 10.8089 mL 21.6179 mL
5 mM 0.4324 mL 2.1618 mL 4.3236 mL
10 mM 0.2162 mL 1.0809 mL 2.1618 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Fedovapagon Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Fedovapagon347887-36-9VA106483VA 106483VA-106483Vasopressin ReceptorNocturiaurinebenzylureasInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Fedovapagon
Cat. No.:
HY-14887
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.