1. Anti-infection
    Metabolic Enzyme/Protease
  2. HIV
    Endogenous Metabolite
  3. Fosamprenavir Calcium Salt

Fosamprenavir Calcium Salt  (Synonyms: GW433908G)

Cat. No.: HY-17431 Purity: 98.25%
COA Handling Instructions

Fosamprenavir Calcium Salt (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility. Anti-HIV infection.

For research use only. We do not sell to patients.

Fosamprenavir Calcium Salt Chemical Structure

Fosamprenavir Calcium Salt Chemical Structure

CAS No. : 226700-81-8

Size Price Stock Quantity
1 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 165 In-stock
Estimated Time of Arrival: December 31
10 mg USD 275 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Fosamprenavir Calcium Salt:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

Fosamprenavir Calcium Salt (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility[1]. Anti-HIV infection[1].

IC50 & Target

HIV[1]

In Vitro

The calcium salt of the prodrug, Fosamprenavir Calcium Salt (GW433908G), is selected for further investigation, as it appears to offer the greatest potential for the development of new drug formulations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

623.67

Formula

C25H34CaN3O9PS

CAS No.
SMILES

O=C(O[[email protected]@H]1COCC1)N[[email protected]@H](CC2=CC=CC=C2)[[email protected]](OP([O-])([O-])=O)CN(S(=O)(C3=CC=C(N)C=C3)=O)CC(C)C.[Ca+2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (80.17 mM; Need ultrasonic)

H2O : 0.25 mg/mL (0.40 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6034 mL 8.0171 mL 16.0341 mL
5 mM 0.3207 mL 1.6034 mL 3.2068 mL
10 mM 0.1603 mL 0.8017 mL 1.6034 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.01 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.01 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.01 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2

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Product Name:
Fosamprenavir Calcium Salt
Cat. No.:
HY-17431
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