POLQ-IN-1
POLQ-IN-1 is a DNA polymerase θ (POLQ) inhibitor with a pIC50 of 8.2. POLQ-IN-1 inhibits the proliferation of homologous recombination-deficient cells. POLQ-IN-1 is used for the research of homologous recombination-deficient tumors.
For research use only. We do not sell to patients.
- CAS No.: 3109024-27-0
- Formula: C28H26ClF3N4O5
- Molecular Weight:590.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
POLQ-IN-1 (Compound 9) inhibits the proliferation of BRCA2-deficient cells with a pIC50 of 6.2[1].
POLQ-IN-1 exhibits only extremely low antiproliferative activity in DLD1 cells, with a pIC50 value of <5.0[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3109024-27-0
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Molecular Weight 590.98
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Formula C28H26ClF3N4O5
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SMILES
O=C(C(CCOC1=CC(Cl)=C(C2=NC3=C(N2CC4=CC(OC(F)(F)F)=CC=C4)N=CN=C3OC5(CC5)C)C=C1)C)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
POLQ-IN-1 Related Classifications
HY-182322 Related Classifications
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