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Referencia número: HY-139854

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DNDI-6148

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Based on 1 Customer Validation

DNDI-6148 is a novel preclinical candidate for the research of visceral leishmaniasis.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 99.54%
No. CAS: 2243909-59-1
Fòrmula: C₁₆H₁₄BN₅O₃
Peso molecular:335.13

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

DNDI-6148 Chemical Structure

No. CAS: 2243909-59-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
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Bioz

Actividad biológica

Descripciòn

DNDI-6148 is a novel preclinical candidate for the research of visceral leishmaniasis.

IC₅₀ & Target

Leishmania

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Cellular Effect

Cell Line	Type	Value	Description	References
MRC5	CC₅₀	>64 μM Compound: 23; DNDI-6148	Cytotoxicity against human MRC5 cells measured after 3 days by resazurin staining based fluorometric analysis Cytotoxicity against human MRC5 cells measured after 3 days by resazurin staining based fluorometric analysis	[PMID: 34711050]
Peritoneal macrophage	CC₅₀	>64 μM Compound: 23; DNDI-6148	Cytotoxicity against mouse primary peritoneal macrophages measured after 3 days by resazurin staining based fluorometric analysis Cytotoxicity against mouse primary peritoneal macrophages measured after 3 days by resazurin staining based fluorometric analysis	[PMID: 34711050]

Chemical Information

No. CAS 2243909-59-1
Appearance Solid
Peso molecular 335.13
Fòrmula C₁₆H₁₄BN₅O₃
Color Off-white to light yellow
SMILES

O=C(C1=C(C)N(C2=NC=CC=C2)N=N1)NC3=CC=C4C(B(O)OC4)=C3
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Mowbray CE, et al. DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis. J Med Chem. 2021 Nov 11;64(21):16159-16176. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- IC₅₀ & Target
Chemical Information
Pureza y Documentación
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DNDI-6148

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DNDI-6148 Related Classifications

HY-139854 Related Classifications