MU1700
MU1700, a chemical probe, is an orally active and potent ALK1/2 inhibitor with IC50s of 13 nM and 6 nM, respectively. MU1700 shows cell membrane permeability and high brain permeability.
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- No. CAS: 3055312-41-6
- Fòrmula: C26H22N4O
- Peso molecular:406.48
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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ALK2 6 nM (IC50) |
ALK1 13 nM (IC50) |
ALK6 41 nM (IC50) |
MU1700 (0.1-50 μM; 24 h) shows cytotoxic effect at above 2.5 µM in U2OS cells[1].
MU1700 (0-10 μM) inhibits ALK2 catalysed phosphorylation of SMAD1/5/8[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U2OS cells
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Concentration:0.1-50 μM
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Incubation Time:24 h
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Result:Showed cytotoxic effect above 2.5 µM concentration significantly.
| Dose | 20 mg/kg |
| Bioavailability | 79 % |
| Cl (ml/min/kg) | 30 (IV) |
| T1/2 | 2.5 h |
| Cmax (PO) | 3697 nM |
| Cbrain/Cplasma (4h, 100 mg/kg) | 25 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3055312-41-6
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Peso molecular 406.48
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Fòrmula C26H22N4O
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SMILES
N1(C2=CC=C(C3=CC(OC=C4C5=C(C=CC=C6)C6=NC=C5)=C4N=C3)C=C2)CCNCC1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MU1700 Related Classifications
HY-148246 Related Classifications
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