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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
614 Results for "
tgf-
" in MedChemExpress (MCE) Product Catalog:
Products (614)
614 Results for "tgf-" in MCE Product Catalog:
302
302 Publications Verification
Target:
Áreas de investigación:
SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways .
150
134
134 Cited Publications
Target:
Áreas de investigación:
A 83-01 sodium is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively .
134
134 Cited Publications
Target:
Áreas de investigación:
A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively .
107
107 Cited Publications
Target:
Áreas de investigación:
SIS3 is a potent and selective inhibitor of Smad3 with an IC50 of 3 μM for Smad3 phosphorylation. SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1 .
107
107 Cited Publications
Target:
Áreas de investigación:
SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2 .
83
Target:
Áreas de investigación:
Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities .
72
Target:
Áreas de investigación:
Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cilengitide (EMD 121974) is a BBB-permeable integrins antagonist with IC50s of 0.61 nM (ανβ3), 8.4 nM (ανβ5) and 14.9 nM (α5β1), respectively. Cilengitide inhibits the binding of ανβ3 and ανβ5 to Vitronectin with IC50s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-β/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis, shows antiangiogenic effect in the research against glioblastoma and other cancers .
71
71 Cited Publications
Synonyms: LY2157299
Target:
Áreas de investigación:
Galunisertib (LY2157299) is an oral and selective TGF-β receptor type I (TGF-βRI) kinase inhibitor with an IC50 of 56 nM.
71
71 Cited Publications
Target:
Áreas de investigación:
LY2109761 is an orally active, selective TGF-β receptor type I/II inhibitor with Kis of 38 nM and 300 nM, respectively.
61
58
58 Cited Publications
Target:
Áreas de investigación:
SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects .
58
58 Cited Publications
Target:
Áreas de investigación:
SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects, with blood-brain barrier permeability .
50
50 Cited Publications
Referencia número: HY-P70543
Pureza: ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: Transforming Growth Factor Beta-1; tgf-Beta-1; Latency-Associated Peptide; LAP; tgfB1; tgfB; tgf-β1; tgf beta1; tgfbeta 1; tgf-beta 1; tgfbeta; tgf-beta-1
25
25 Cited Publications
Referencia número: HY-P70648
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: tgf-beta-1; CED; DPD1; tgfB; tgf-b1; tgfB1; CEDLAP; latency-associated peptide; tgfbeta; tgf-beta 1 protein; transforming growth factor beta-1; tgf-β1; tgf beta1; tgfbeta 1; tgf-beta 1; tgfbeta
24
24 Cited Publications
Synonyms: HTS466284
Target:
Áreas de investigación:
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, and exhibits 7-fold selectivity over TGFβR-II .
23
23 Cited Publications
Target:
Áreas de investigación:
SB-505124 is a selective inhibitor of TGF-β Receptor type I receptors (ALK4, ALK5, ALK7), with IC50s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6.
23
23 Cited Publications
Target:
Áreas de investigación:
SB-505124 hydrochloride is a selective inhibitor of TGF-β Receptor type I receptor (ALK4, ALK5, ALK7), with IC50s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6.
21
21 Cited Publications
Synonyms: E-616452; SJN 2511
Target:
Áreas de investigación:
RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes .
20
20 Cited Publications
Referencia número: HY-N0158
No. CAS: 16837-52-8
Category:
Infection Alkaloids Piperidine Alkaloids Leguminosae Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology
Target:
-
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
