R 29676
Based on 1 Customer Validation
R 29676 is a neuroleptic agent and inhibits sodium-dependent GABA binding (GABA uptake).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.80%
- No. CAS: 53786-28-0
- Fòrmula: C12H14ClN3O
- Peso molecular:251.71
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-W103105R
R 29676 (Standard)
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HY-B0411
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Albendazole
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HY-B0413
Fenbendazole
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HY-Y1825
Benzimidazole
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Fenbendazole (Standard)
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HY-W017511
5,6-Dimethyl-1H-benzo[d]imidazole
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HY-Y0410
2-Aminobenzimidazole
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HY-109654
Ensulizole
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HY-Y1825R
Benzimidazole (Standard)
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HY-W008003
2-Hydroxybenzimidazole
Actividad biológica
Chemical Information
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No. CAS 53786-28-0
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Appearance Solid
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Peso molecular 251.71
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Fòrmula C12H14ClN3O
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Color White to off-white
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SMILES
C1=CC2=C(C=C1Cl)N=C(N2C3CCNCC3)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (397.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (19.86 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (19.86 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9728 mL | 19.8641 mL | 39.7283 mL | 99.3206 mL |
| 5 mM | 0.7946 mL | 3.9728 mL | 7.9457 mL | 19.8641 mL | |
| 10 mM | 0.3973 mL | 1.9864 mL | 3.9728 mL | 9.9321 mL | |
| 15 mM | 0.2649 mL | 1.3243 mL | 2.6486 mL | 6.6214 mL | |
| 20 mM | 0.1986 mL | 0.9932 mL | 1.9864 mL | 4.9660 mL | |
| 25 mM | 0.1589 mL | 0.7946 mL | 1.5891 mL | 3.9728 mL | |
| 30 mM | 0.1324 mL | 0.6621 mL | 1.3243 mL | 3.3107 mL | |
| 40 mM | 0.0993 mL | 0.4966 mL | 0.9932 mL | 2.4830 mL | |
| 50 mM | 0.0795 mL | 0.3973 mL | 0.7946 mL | 1.9864 mL | |
| 60 mM | 0.0662 mL | 0.3311 mL | 0.6621 mL | 1.6553 mL | |
| 80 mM | 0.0497 mL | 0.2483 mL | 0.4966 mL | 1.2415 mL | |
| 100 mM | 0.0397 mL | 0.1986 mL | 0.3973 mL | 0.9932 mL |
R 29676 Related Classifications
HY-W103105 Related Classifications
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