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Referencia número: HY-168536

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SJ46411

SJ46411 is a potent ligand for KLHDC2, with a K_d of ~260 nM measured by isothermal titration calorimetry (SPR K_d = 0.5 μM, TR-FRET IC₅₀ = 3.9 μM, ΔTm = 6.0 °C).

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No. CAS: 3086104-39-1
Fòrmula: C₁₇H₁₄N₂O₃S
Peso molecular:326.37

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SJ46411 Chemical Structure

No. CAS: 3086104-39-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

SJ46411 is a potent ligand for KLHDC2, with a K_d of ~260 nM measured by isothermal titration calorimetry (SPR K_d = 0.5 μM, TR-FRET IC₅₀ = 3.9 μM, ΔTm = 6.0 °C)^[1].

IC₅₀ & Target

KLHDC2

Ver todos los productos específicos de isoformas Ligands for E3 Ligase :

Chemical Information

No. CAS 3086104-39-1
Peso molecular 326.37
Fòrmula C₁₇H₁₄N₂O₃S
SMILES

O=C(CNC(CC1=CSC(C2=CC=C3C=CC=CC3=C2)=N1)=O)O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Daniel C Scott, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15(1):8829. doi: 10.1038/s41467-024-52966-3. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- IC₅₀ & Target
Chemical Information
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SJ46411

Ver todos los productos específicos de isoformas Ligands for E3 Ligase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

SJ46411 Related Classifications

HY-168536 Related Classifications