VEGFR-IN-3
VEGFR-IN-3 (compound 3f) is a VEGFR inhibitor. VEGFR-IN-3 inhibits OVCAR-4 and MDA-MB-468 cancer cells growth with IC50s of 0.29 and 0.35 μM, respectively. VEGFR-IN-3 can be used for the research of cancer.
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- No. CAS: 2874264-13-6
- Fòrmula: C27H28N2O6
- Peso molecular:476.52
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
IC50: 0.29 μM (OVCAR-4), 0.35 μM (MDA-MB-468), 25.9 μM (MCF-10A)[1]
VEGFR-IN-3 (10 μM; 60 min) inhibits a variety of cancer cell lines growth[1]. VEGFR-IN-3 (0-100 μM; 72 h) shows cytotoxic activities against MDA-MB-468 and OVCAR-4 cancer cell lines[1]. VEGFR-IN-3 (0.29-0.35 μM; 2.5 h) decreases the concentration of VEGF in OVCAR-4 and MDA-MB-468 cell lines[1]. VEGFR-IN-3 (0.29 μM; 48 h) increases levels of ERK1 and ERK2, activates ERK1 and ERK2 phosphorylation[1]. VEGFR-IN-3 (0.29 μM; 24 h) affects cell cycle and induces apoptosis of OVCAR-4 cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Leukemia, non-small cell lung cancer, colon cancer, CNS cancer, Melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer cell lines
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Concentration:10 μM
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Incubation Time:60 min
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Result:Showed significantly antiproliferative activities against Leukemia, non-small cell lung cancer, colon cancer, CNS cancer, Melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer cell lines with GI% ranging from 49.1% to 98.46%.
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Cell Line:MDA-MB-468 and OVCAR-4 cancer cell lines, MCF-10A normal breast cancer cell line
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Concentration:0-100 μM
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Incubation Time:72 hours
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Result:Inhibited MDA-MB-468, OVCAR-4 and MCF-10A cells growth with IC50 values of 0.35, 0.29 and 25.9 μM, respectively.
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Cell Line:OVCAR-4 cell line
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Concentration:0.29 μM
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Incubation Time:24 hours
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Result:Induced OVCAR-4 cells apoptosis by increasing the number of early and late apoptosis cells.
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Cell Line:OVCAR-4 cell line
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Concentration:0.29 μM
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Incubation Time:24 hours
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Result:Arrested cell cycle in the S phase and increased the number of OVCAR-4 cells in pre-G1 phase.
Chemical Information
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No. CAS 2874264-13-6
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Peso molecular 476.52
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Fòrmula C27H28N2O6
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SMILES
CC(N(C(C1)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC)N=C1C4=CC(OC)=C(OC)C(OC)=C4)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VEGFR-IN-3 Related Classifications
HY-143293 Related Classifications
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