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Referencia número: HY-184281

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XAT-14

XAT-14 is a Furanocoumarin derivative. XAT-14 competes with agonists to bind to the active pocket of MRGPRX2, inhibiting calcium influx and mast cell degranulation. XAT-14 suppresses the release of histamine, IL-8 and MCP-1 induced by Compound 48/80 (HY-115768). XAT-14 inhibits local allergic inflammation. XAT-14 can be used for the research of pseudo-allergic diseases.

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No. CAS: 3107904-59-3
Fòrmula: C₂₁H₁₈O₅
Peso molecular:350.36

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Please store the product under the recommended conditions in the Certificate of Analysis.

XAT-14 Chemical Structure

No. CAS: 3107904-59-3

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IC₅₀ & Target^[1]

IL-8

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In Vitro

XAT-14 (100 μM) shows no cytotoxicity in LAD2 cells^[1].
XAT-14 (25-100 μM) potently inhibits Compound 48/80-induced β-hexosaminidase release in LAD2 cells, with an IC₅₀ of 22.95 μM, and exhibits superior efficacy to Imperatorin (HY-N0285)^[1].
XAT-14 (25-100 μM) dose-dependently inhibits Compound 48/80-induced release of histamine, IL-8 and MCP-1 in LAD2 cells^[1].
XAT-14 (25-100 μM) inhibits Compound 48/80-induced calcium influx in MRGPRX2-HEK293 cells in a dose-dependent manner, indicating that its effect is mediated through the MRGPRX2 signaling pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

XAT-14 (4-16 mg/kg) reduces the degree of hindlimb swelling and Evans blue extravasation induced by C48/80 in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3107904-59-3
Peso molecular 350.36
Fòrmula C₂₁H₁₈O₅
SMILES

O=C1OC2=C(OCCCOCC3=CC=CC=C3)C4=C(C=CO4)C=C2C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Yang W, et al. Furanocoumarin derivatives inhibit MRGPRX2-mediated pseudo-allergy. Bioorganic & medicinal chemistry letters. 2026 Jun;135:130589. [Content Brief]

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XAT-14

High-Throughput Bioactive Compound Library

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