3107904-59-3
3107904-59-3
Chemical Structure
XAT-14
- CAS No.: 3107904-59-3
- Formula:C21H18O5
- Molecular Weight:350.36
InChIKey: WKCPNPKVMRFMAL-UHFFFAOYSA-N
SMILES: O=C1OC2=C(OCCCOCC3=CC=CC=C3)C4=C(C=CO4)C=C2C=C1
Biological Activity: XAT-14 is a Furanocoumarin derivative. XAT-14 competes with agonists to bind to the active pocket of MRGPRX2, inhibiting calcium influx and mast cell degranulation. XAT-14 suppresses the release of histamine, IL-8 and MCP-1 induced by Compound 48/80 (HY-115768). XAT-14 inhibits local allergic inflammation. XAT-14 can be used for the research of pseudo-allergic diseases[1].
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XAT-14 | XAT-14 is a Furanocoumarin derivative. XAT-14 competes with agonists to bind to the active pocket of MRGPRX2, inhibiting calcium influx and mast cell degranulation. XAT-14 suppresses the release of histamine, IL-8 and MCP-1 induced by Compound 48/80 (HY-115768). XAT-14 inhibits local allergic inflammation. XAT-14 can be used for the research of pseudo-allergic diseases. | |||||||||||||||||||||
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References
Keywords
