country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-184281

Copy Link Print Information

XAT-14

XAT-14 is a Furanocoumarin derivative. XAT-14 competes with agonists to bind to the active pocket of MRGPRX2, inhibiting calcium influx and mast cell degranulation. XAT-14 suppresses the release of histamine, IL-8 and MCP-1 induced by Compound 48/80 (HY-115768). XAT-14 inhibits local allergic inflammation. XAT-14 can be used for the research of pseudo-allergic diseases.

For research use only. We do not sell to patients.

CAS No.: 3107904-59-3
Formula: C₂₁H₁₈O₅
Molecular Weight:350.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

XAT-14 Chemical Structure

CAS No.: 3107904-59-3

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

IL-8

All Calcium Channel Isoforms :

All Interleukin Related Isoforms :

In Vitro

XAT-14 (100 μM) shows no cytotoxicity in LAD2 cells^[1].
XAT-14 (25-100 μM) potently inhibits Compound 48/80-induced β-hexosaminidase release in LAD2 cells, with an IC₅₀ of 22.95 μM, and exhibits superior efficacy to Imperatorin (HY-N0285)^[1].
XAT-14 (25-100 μM) dose-dependently inhibits Compound 48/80-induced release of histamine, IL-8 and MCP-1 in LAD2 cells^[1].
XAT-14 (25-100 μM) inhibits Compound 48/80-induced calcium influx in MRGPRX2-HEK293 cells in a dose-dependent manner, indicating that its effect is mediated through the MRGPRX2 signaling pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

XAT-14 (4-16 mg/kg) reduces the degree of hindlimb swelling and Evans blue extravasation induced by C48/80 in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3107904-59-3
Molecular Weight 350.36
Formula C₂₁H₁₈O₅
SMILES

O=C1OC2=C(OCCCOCC3=CC=CC=C3)C4=C(C=CO4)C=C2C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang W, et al. Furanocoumarin derivatives inhibit MRGPRX2-mediated pseudo-allergy. Bioorganic & medicinal chemistry letters. 2026 Jun;135:130589. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

XAT-14

High-Throughput Bioactive Compound Library

All Calcium Channel Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

XAT-14 Related Classifications

HY-184281 Related Classifications