TAAR1 - trace amine associated receptor 1 Gene

Also Known as TA1; TAR1; TRAR1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 134864

About TAAR1

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:132,643,312-132,659,182 (from NCBI)

This gene has 1 transcript (splice variant), 601 orthologues and 25 paralogues.

Summary

The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]

TAAR1 Products (1)

mRNA Protein Name
NM_138327.4 NP_612200.1 trace amine-associated receptor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
11723224 GOA
enables trace-amine receptor activity IDA
IDA: Inferred from direct assay
11459929 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11723224 GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
31399635 GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
37935376 GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
37935376 GOA
Cellular Component GO Annotation Evidence References Source
is active in endomembrane system IDA
IDA: Inferred from direct assay
11723224 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAAR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (40 - 304)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
Protein Preferred Names Protein Names

trace amine-associated receptor 1

  • trace amine receptor 1

Related Diseases

Diseases Alias
Superficial Urinary Bladder Cancer

  • Superficial Urinary Bladder Carcinoma

  • Carcinoma Of Urinary Bladder, Superficial
Hypoparathyroidism-Deafness-Renal Disease Syndrome

  • Barakat Syndrome

  • Hypoparathyroidism, Deafness, Renal Disease Syndrome

  • Hdr Syndrome

  • Hypoparathyroidism, Sensorineural Deafness, And Renal Disease
Baastrup'S Syndrome

  • Kissing Spine

  • Baastrup Syndrome

  • Kissing Spine, Site Unspecified

  • Osteoarthrosis Interspinalis

  • Overriding Of Dorsal Spinous Processes

  • Localised Idiopathic Skeletal Hyperostosis

  • Baastrup Disease
Diamond-Blackfan Anemia 7

  • DBA7

  • Rpl11-Related Diamond-Blackfan Anemia

  • Anemia, Diamond-Blackfan, Type 7
Trichothiodystrophy 6, Nonphotosensitive

  • TTD6

  • Nonphotosensitive Trichothiodystrophy 6

  • Trichothiodystrophy 6, Non-Photosensitive
Joubert Syndrome 32

  • JBTS32
Greig Cephalopolysyndactyly Syndrome

  • GCPS

  • Polysyndactyly With Peculiar Skull Shape

  • Polysyndactyly With Peculiars Skull Shape

  • Greig Syndrome

  • Cephalopolysyndactyly Syndrome

  • Greig Cephalo-Poly-Syndactyly Syndrome

  • Cephalopolysyndactyly, Greig Syndrome

  • Aarskog Syndrome
Acrocallosal Syndrome

  • ACLS

  • Schinzel Acrocallosal Syndrome

  • Joubert Syndrome 12

  • Schinzel Syndrome 1

  • Acrocallosal Syndrome, Schinzel Type

  • Hallux Duplication, Postaxial Polydactyly, And Absence Of Corpus Callosum

  • Acs

  • Absence Of Corpus Callosum With Unusual Facial Appearance, Mental Deficiency, Duplication Of The Halluces And Polydactyly

  • Hallux Duplication Postaxial Polydactyly And Absence Of Corpus Callosum

  • JBTS12

  • Acrocallosal Syndrome
Pallister-Hall Syndrome

  • PHS

  • Hypothalamic Hamartomas

  • Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly

  • Hypothalamic Hamartoblastoma Syndrome

  • Hamartoma Of The Hypothalamus

  • Pallister Hall Syndrome

  • Hall-Pallister Syndrome

  • Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly

  • Hamartoma, Hypothalamic
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-136109 Ulotaront hydrochloride Agonist 99.89% Phase 3
HY-136109A Ulotaront Agonist / Phase 3
HY-109157 Ralmitaront Agonist 99.92% Phase 2

Pre-clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110098 Ro 5212773 99.85% Unkown
HY-103638 3-Methoxytyramine hydrochloride 98.23% Unkown
HY-12700 RO5256390 Agonist 98.75% Unkown
HY-108015 RO5263397 99.10% Unkown
HY-42346 ZH8651 Agonist 99.71% Unkown
HY-12699 RO5166017 Agonist 98.21% Unkown
HY-103638S 3-Methoxytyramine-d4 hydrochloride 98.66% Unkown
HY-103054 RO5203648 98.10% Unkown
HY-135065 3-Iodothyronamine hydrochloride Activator 99.5% Unkown
HY-W005394 2-Phenylpropan-1-amine hydrochloride 98.96% Unkown
HY-160001A ZH8659 hydrochloride Activator 99.21% Unkown
HY-176141 ZH8965 Agonist 99.48% Unkown
HY-117021 RO 5073012 Agonist / Unkown
HY-136109E SEP-363856 mesylate Agonist / Unkown
HY-157955 TAAR1 agonist 1 Agonist / Unkown
HY-157955A TAAR1 agonist 1 hydrochloride Agonist / Unkown
HY-160001 ZH8659 Activator / Unkown
HY-173451 TAAR1/5-H-2CR agonist-1 Agonist / Unkown
HY-173471 TRPA1 agonist-1 Agonist / Unkown
HY-183428 LK00764 Agonist / Unkown
HY-183489 TAAR1-agonist-4 Agonist / Unkown
HY-186230 RO5192022 Agonist / Unkown
HY-RS14130 TAAR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W502657 ZH8667 Agonist / Unkown
HY-W704807 3-Methoxytyramine-d3 hydrochloride / Unkown
HY-W755778 3-Iodothyronamine hydrochloride-13C6 / Unkown
HY-W909149 TAAR1 agonist 3 Agonist / Unkown
HY-W909173 TAAR1 agonist 2 Agonist / Unkown
HY-34713 N-Methylphenethylamine hydrochloride Agonist / Unkown
HY-RS16814 Taar1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23254 Taar1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W634602 (R)-RO5263397 Agonist / Unkown
HY-W680886 6-APDB / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TAAR1 VGNC VGNC:83474
Mus musculus TAAR1 MGD MGI:2148258
Bos taurus TAAR1 VGNC VGNC:35553
Felis catus TAAR1 VGNC VGNC:65912
Rattus norvegicus TAAR1 RGD RGD:621621
Others TAAR1 NCBI