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RO5263397 

Cat. No.: HY-108015
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RO5263397 is a potent, selective, and orally available TAAR1 agonist, with EC50s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively. RO5263397 regulates wakefulness and EEG spectral composition. Antidepressant-like effect.

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RO5263397 Chemical Structure

RO5263397 Chemical Structure

CAS No. : 1357266-05-7

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Description

RO5263397 is a potent, selective, and orally available TAAR1 agonist, with EC50s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively. RO5263397 regulates wakefulness and EEG spectral composition. Antidepressant-like effect[1][2][3].

In Vivo

RO5263397 (0.1-1.0 mg/kg; p.o.; dosing at the mid-light phase (ZT6)) increased wake time at 0.3 and 1 mg/kg[2].
RO5263397 (0.3 and 1.0 mg/kg; p.o.) decreases NREM time in WT mice. RO5263397 (0.3 and 1.0 mg/kg; p.o.; in OE mice) powerfully increases W time in OE mice for 5-6 h. NREM sleep is suppressed for 4-6 h and REM sleep is almost completely suppressed for 6 h after all doses of RO5263397[3].

Animal Model: Adult 4-5-month-old male WT littermates (C57BL/6 background)[2]
Dosage: 0.1, 0.3, 1 mg/kg
Administration: p.o.; dosing at the mid-light phase (ZT6) 
Result: Increased wake time at 0.3 and 1 mg/kg
Molecular Weight

194.21

Formula

C₁₀H₁₁FN₂O

CAS No.

1357266-05-7

SMILES

CC1=C([[email protected]@H]2N=C(N)OC2)C=CC=C1F

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

RO5263397RO 5263397RO-5263397OtherswakefulnessspectralNREMREMsleeprhythmsantidepressantpsychiatricInhibitorinhibitorinhibit

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RO5263397
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HY-108015
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