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Cat. No.: HY-173471

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TRPA1 agonist-1

TRPA1 agonist-1 (compound 21) is a potent and selective TAAR1 agonist with an EC₅₀ of 25.47 μM. TRPA1 agonist-1 shows effective analgesic properties without irritation in mice.

For research use only. We do not sell to patients.

Formula: C₁₅H₂₀N₂OS
Molecular Weight:276.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

TRPA1 agonist-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

TRPA1 agonist-1 (compound 21) is a potent and selective TAAR1 agonist with an EC₅₀ of 25.47 μM. TRPA1 agonist-1 shows effective analgesic properties without irritation in mice^[1].

All TRP Channel Isoforms :

Chemical Information

Molecular Weight 276.40
Formula C₁₅H₂₀N₂OS
SMILES

CCC1=CC=C(C2=CSC(NCCCOC)=N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang N, et al. Discovery of non-electrophilic TRPA1 channel agonists with anti-nociceptive effects via rapid current desensitization. Eur J Med Chem. 2025 Jul 5;291:117586. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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TRPA1 agonist-1

All TRP Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TRPA1 agonist-1 Related Classifications

HY-173471 Related Classifications