MARCKS - Marcks myristoylated alanine rich protein kinase C substrate Gene

Also Known as KINC; Macs

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25603

Summary

Enables phosphatidylserine binding activity. Involved in several processes, including activation of Phospholipase D activity; positive regulation of protein kinase C activity; and regulation of synapse organization. Located in several cellular components, including bleb; dendrite; and distal axon. Is active in glutamatergic synapse; postsynaptic cytoskeleton; and presynaptic cytosol. Is anchored component of postsynaptic membrane and anchored component of presynaptic membrane. Colocalizes with microtubule. Biomarker of visual epilepsy. Orthologous to human MARCKS (myristoylated alanine rich protein kinase C substrate). [provided by Alliance of Genome Resources, Apr 2022]

MARCKS Products (1)

mRNA Protein Name
NM_001271090.3 NP_001258019.2 myristoylated alanine-rich C-kinase substrate

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylserine binding IDA
IDA: Inferred from direct assay
8276751 RGD
enables phospholipid binding IDA
IDA: Inferred from direct assay
8611023 RGD
Biological Process GO Annotation Evidence References Source
involved in actin filament organization IMP
IMP: Inferred from mutant phenotype
16987960 RGD
involved in activation of phospholipase D activity IDA
IDA: Inferred from direct assay
16341931 RGD
involved in cell-substrate adhesion IDA
IDA: Inferred from direct assay
19509053 RGD
involved in intracellular protein transport IMP
IMP: Inferred from mutant phenotype
11882609 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
16202710 RGD
involved in positive regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19252893 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
16987960 RGD
involved in positive regulation of protein kinase C activity IDA
IDA: Inferred from direct assay
16341931 RGD
involved in regulation of modification of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
16202710 RGD
involved in regulation of modification of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
16202710 RGD
involved in ventricular cardiac muscle tissue development IEP
IEP: Inferred from expression pattern
9205551 RGD
Cellular Component GO Annotation Evidence References Source
located in axon terminus IDA
IDA: Inferred from direct assay
2332803 RGD
located in bleb IDA
IDA: Inferred from direct assay
16341931 RGD
located in chromatoid body IDA
IDA: Inferred from direct assay
21764106 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
19683798 RGD
located in dendritic branch IDA
IDA: Inferred from direct assay
2332803 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
2332803 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16202710 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
16202710 RGD
located in growth cone IDA
IDA: Inferred from direct assay
16987960 RGD
located in microtubule IDA
IDA: Inferred from direct assay
2332803 RGD
located in outer dense fiber IDA
IDA: Inferred from direct assay
21764106 RGD
is active in postsynaptic cytoskeleton IDA
IDA: Inferred from direct assay
2332803 RGD
is active in postsynaptic membrane EXP
EXP: Inferred from Experiment
2332803 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
2332803 RGD
is active in presynaptic cytosol EXP
EXP: Inferred from Experiment
2332803 RGD
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
2332803 RGD
is active in presynaptic membrane EXP
EXP: Inferred from Experiment
2332803 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
2332803 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myristoylated alanine-rich C-kinase substrate

  • Myristoylated alanine-rich protein kinase C substrate

  • protein kinase C substrate 80 kDa protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-10343 Sotrastaurin 99.79% Phase 2
HY-106377A BIO-11006 acetate 99.92% Phase 2
HY-106377 BIO-11006 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12359 TPPB 99.92% Unkown
HY-P10218A MANS peptide TFA 99.88% Unkown
HY-P10471A MPSD TFA 99.81% Unkown
HY-113616A VU0364572 TFA 98.79% Unkown
HY-P10218 MANS peptide 99.66% Unkown
HY-P10471E MPSD control peptide TFA Control 95.83% Unkown
HY-P10471 MPSD / Unkown
HY-P10471D MPSD control peptide Control / Unkown
HY-P10471B Ala-MPSD / Unkown
HY-P5439 Epsilon-V1-2, Cys-conjugated / Unkown
HY-113616 VU0364572 / Unkown
HY-121197 Balanol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens MARCKS NCBI NCBI:4082