MARCKS - Marcks myristoylated alanine rich protein kinase C substrate Gene

Rattus norvegicus

Also known as KINC; Macs

Gene ID: 25603 | Gene type: protein coding

About MARCKS

Summary

Enables phosphatidylserine binding activity. Involved in several processes, including activation of Phospholipase D activity; positive regulation of protein kinase C activity; and regulation of synapse organization. Located in several cellular components, including bleb; dendrite; and distal axon. Is active in glutamatergic synapse; postsynaptic cytoskeleton; and presynaptic cytosol. Is anchored component of postsynaptic membrane and anchored component of presynaptic membrane. Colocalizes with microtubule. Biomarker of visual epilepsy. Orthologous to human MARCKS (myristoylated alanine rich protein kinase C substrate). [provided by Alliance of Genome Resources, Apr 2022]

MARCKS Products(1)

mRNA	Protein	Name
NM_001271090.3	NP_001258019.2	myristoylated alanine-rich C-kinase substrate

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	8276751	RGD
enables phospholipid binding	IDA IDA: Inferred from direct assay	8611023	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	16987960	RGD
involved in activation of phospholipase D activity	IDA IDA: Inferred from direct assay	16341931	RGD
involved in cell-substrate adhesion	IDA IDA: Inferred from direct assay	19509053	RGD
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	11882609	RGD
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	16202710	RGD
involved in positive regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19252893	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	16987960	RGD
involved in positive regulation of protein kinase C activity	IDA IDA: Inferred from direct assay	16341931	RGD
involved in regulation of modification of postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	16202710	RGD
involved in regulation of modification of postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	16202710	RGD
involved in ventricular cardiac muscle tissue development	IEP IEP: Inferred from expression pattern	9205551	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon terminus	IDA IDA: Inferred from direct assay	2332803	RGD
located in bleb	IDA IDA: Inferred from direct assay	16341931	RGD
located in chromatoid body	IDA IDA: Inferred from direct assay	21764106	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	19683798	RGD
located in dendritic branch	IDA IDA: Inferred from direct assay	2332803	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	2332803	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16202710	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	16202710	RGD
located in growth cone	IDA IDA: Inferred from direct assay	16987960	RGD
located in microtubule	IDA IDA: Inferred from direct assay	2332803	RGD
located in outer dense fiber	IDA IDA: Inferred from direct assay	21764106	RGD
is active in postsynaptic cytoskeleton	IDA IDA: Inferred from direct assay	2332803	RGD
is active in postsynaptic membrane	EXP EXP: Inferred from Experiment	2332803	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	2332803	RGD
is active in presynaptic cytosol	EXP EXP: Inferred from Experiment	2332803	RGD
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	2332803	RGD
is active in presynaptic membrane	EXP EXP: Inferred from Experiment	2332803	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	2332803	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myristoylated alanine-rich C-kinase substrate

Myristoylated alanine-rich protein kinase C substrate

protein kinase C substrate 80 kDa protein

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10343	Sotrastaurin		99.79%	Phase 2
HY-106377A	BIO-11006 acetate		99.92%	Phase 2
HY-106377	BIO-11006	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12359	TPPB		99.92%	Unkown
HY-P10218A	MANS peptide TFA		99.88%	Unkown
HY-P10471A	MPSD TFA		99.81%	Unkown
HY-113616A	VU0364572 TFA		98.79%	Unkown
HY-P10218	MANS peptide		99.66%	Unkown
HY-P10471E	MPSD control peptide TFA	Control	95.83%	Unkown
HY-P10471	MPSD		/	Unkown
HY-P10471D	MPSD control peptide	Control	/	Unkown
HY-P10471B	Ala-MPSD		/	Unkown
HY-P5439	Epsilon-V1-2, Cys-conjugated		/	Unkown
HY-113616	VU0364572		/	Unkown
HY-121197	Balanol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	MARCKS	NCBI	NCBI:4082

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