MARCKS - myristoylated alanine rich protein kinase C substrate Gene

Also Known as MACS; 80K-L; PKCSL; PRKCSL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4082

About MARCKS

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:113,857,345-113,863,475 (from NCBI)

This gene has 1 transcript (splice variant), 214 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 86.0), colon (RPKM 50.6) and 25 other tissues.

Summary

The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]

MARCKS Products (1)

mRNA Protein Name
NM_002356.7 NP_002347.5 myristoylated alanine-rich C-kinase substrate

MARCKS Protein Structure

MARCKS

MARCKS: MARCKS family (2 - 329)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
Protein Preferred Names Protein Names

myristoylated alanine-rich C-kinase substrate

  • myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L)

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 14

  • Spinocerebellar Ataxia Type 14

  • SCA14

  • Ataxia, Spinocerebellar, Type 14
Borna Disease

  • Enzootic Encephalomyelitis
Anencephaly

  • Aprosencephaly

  • Anencephalus

  • Congenital Absence Of Brain

  • Absence Of A Large Part Of The Brain And The Skull

  • Anencephalia

  • Anencephalic Monster

  • Brain Absence

  • Brain Agenesis

  • Brain Aplasia

  • Absent Brain

  • Anencephalic

  • Congenital Absence Of Cerebrum

  • Congenital Hemicrania

  • Incomplete Anencephaly
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Neural Tube Defects

  • Spina Bifida

  • Neural Tube Defect

  • NTD

  • Neural Tube Defects, Susceptibility To

  • Spinal Dysraphism

  • Spina Bifida, Susceptibility To

  • Rachischisis

  • Cleft Spine

  • Open Spine

  • Hydrocele Spinalis

  • Neural Tube Defect Nos

  • Sb - [Spina Bifida]

  • Spinal Hernia Nos

  • Spinal Fissure Nos
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-10343 Sotrastaurin 99.79% Phase 2
HY-106377A BIO-11006 acetate 99.92% Phase 2
HY-106377 BIO-11006 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12359 TPPB 99.92% Unkown
HY-P10218A MANS peptide TFA 99.88% Unkown
HY-P10471A MPSD TFA 99.81% Unkown
HY-113616A VU0364572 TFA 98.79% Unkown
HY-P10218 MANS peptide 99.66% Unkown
HY-P10471E MPSD control peptide TFA Control 95.83% Unkown
HY-P10471 MPSD / Unkown
HY-P10471D MPSD control peptide Control / Unkown
HY-P10471B Ala-MPSD / Unkown
HY-P5439 Epsilon-V1-2, Cys-conjugated / Unkown
HY-113616 VU0364572 / Unkown
HY-121197 Balanol / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MARCKS VGNC VGNC:74639
Rattus norvegicus MARCKS RGD RGD:3028
Felis catus MARCKS VGNC VGNC:102456
Mus musculus MARCKS MGD MGI:96907
Bos taurus MARCKS VGNC VGNC:31244
Others MARCKS NCBI