MARCKS - myristoylated alanine rich protein kinase C substrate Gene

Homo sapiens

Also known as MACS; 80K-L; PKCSL; PRKCSL

Gene ID: 4082 | Gene type: protein coding

About MARCKS

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:113,857,345-113,863,475 (from NCBI)

This gene has 1 transcript (splice variant), 214 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 86.0), colon (RPKM 50.6) and 25 other tissues.

Summary

The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]

MARCKS Products(1)

mRNA	Protein	Name
NM_002356.7	NP_002347.5	myristoylated alanine-rich C-kinase substrate

MARCKS Protein Structure

MARCKS

0
100
200
300
332 a.a.

Protein Preferred Names

Protein Names

myristoylated alanine-rich C-kinase substrate

myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L)

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 14

Spinocerebellar Ataxia Type 14	SCA14
Ataxia, Spinocerebellar, Type 14

Borna Disease

Enzootic Encephalomyelitis

Anencephaly

Aprosencephaly	Anencephalus
Congenital Absence Of Brain	Absence Of A Large Part Of The Brain And The Skull
Anencephalia	Anencephalic Monster
Brain Absence	Brain Agenesis
Brain Aplasia	Absent Brain
Anencephalic	Congenital Absence Of Cerebrum
Congenital Hemicrania	Incomplete Anencephaly

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113616A	VU0364572 TFA	Agonist	99.27%	Unkown
HY-P10218A	MANS peptide TFA	Inhibitor	96.06%	Unkown
HY-121197	Balanol	Inhibitor	/	Unkown
HY-P10218	MANS peptide	Inhibitor	/	Unkown
HY-P5437	PKCε (85-92)	Activator	/	Unkown
HY-P5439	Epsilon-V1-2, Cys-conjugated	Inhibitor	/	Unkown
HY-RS08145	MARCKS Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MARCKS	VGNC	VGNC:74639
Rattus norvegicus	MARCKS	RGD	RGD:3028
Felis catus	MARCKS	VGNC	VGNC:102456
Mus musculus	MARCKS	MGD	MGI:96907
Bos taurus	MARCKS	VGNC	VGNC:31244

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