2. Gene
  3. Sh3rf1 - SH3 domain containing ring finger 1 Gene

Sh3rf1 - SH3 domain containing ring finger 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Posh; Sh3md2

Gene ID: 306417 | Gene type: protein coding

About Sh3rf1

Summary

Predicted to enable MAP-kinase scaffold activity and ubiquitin protein Ligase activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; positive regulation of JNK cascade; and regulation of alpha-beta T cell activation. Predicted to be located in lamellipodium. Predicted to be active in cytosol. Orthologous to human SH3RF1 (SH3 domain containing ring finger 1). [provided by Alliance of Genome Resources, Apr 2022]

Sh3rf1 Products(1)

mRNA Protein Name
NM_198764.2 NP_942059.1 E3 ubiquitin-protein ligase SH3RF1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16230351 RGD
Biological Process GO Annotation Evidence Reference Source
involved in response to aldosterone IEP
IEP: Inferred from expression pattern
29713904 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase SH3RF1

RING-type E3 ubiquitin transferase SH3RF1

SH3 domain-containing RING finger protein 1

SH3 multiple domains protein 2

plenty of SH3s

putative E3 ubiquitin-protein ligase SH3RF1

putative scaffolding protein POSH

Sh3rf1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Sh3rf1 Q71F54 Siah1 Rattus norvegicus Q920M9
Anti Bait CoIP
16230351
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12844 SH3RF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sh3rf1 NCBI NCBI:57630