Siah1 - siah E3 ubiquitin protein ligase 1 Gene

Rattus norvegicus

Also known as SIAH; Siah1a

Gene ID: 140941 | Gene type: protein coding

About Siah1

Summary

Enables protein C-terminus binding activity and ubiquitin-protein transferase activity. Involved in neuron apoptotic process; protein destabilization; and ubiquitin-dependent protein catabolic process. Located in several cellular components, including cytosol; early endosome; and nucleus. Orthologous to human SIAH1 (siah E3 ubiquitin protein Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

Siah1 Products(1)

mRNA	Protein	Name
NM_080905.2	NP_543181.2	E3 ubiquitin-protein ligase SIAH1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11786535	RGD
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	11786535	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15951807	RGD
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	2129524	RGD
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	11786535	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	15951807	RGD
located in early endosome	IDA IDA: Inferred from direct assay	11786535	RGD
located in nucleus	IDA IDA: Inferred from direct assay	15951807	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase SIAH1

RING-type E3 ubiquitin transferase SIAH1	seven in absentia 1A
seven in absentia homolog 1	siah-1
siah-1a

Siah1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Siah1	Q920M9	Pclo	Rattus norvegicus	Q9JKS6	Anti Tag CoIP	23403927
Intra	Siah1	Q920M9	Bsn	Rattus norvegicus	O88778	Anti Tag CoIP	23403927

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108705	BI-3802	Inhibitor	99.27%	Unkown
HY-182399	BC-DXI-495	Inhibitor	/	Unkown
HY-RS12891	SIAH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W1124386	BG-DBCO		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Siah1	NCBI	NCBI:6477

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