Siah1 - siah E3 ubiquitin protein ligase 1 Gene

Also Known as SIAH; Siah1a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 140941

Summary

Enables protein C-terminus binding activity and ubiquitin-protein transferase activity. Involved in neuron apoptotic process; protein destabilization; and ubiquitin-dependent protein catabolic process. Located in several cellular components, including cytosol; early endosome; and nucleus. Orthologous to human SIAH1 (siah E3 ubiquitin protein Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

Siah1 Products (1)

mRNA Protein Name
NM_080905.2 NP_543181.2 E3 ubiquitin-protein ligase SIAH1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11786535 RGD
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
11786535 RGD
Biological Process GO Annotation Evidence References Source
involved in neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
15951807 RGD
involved in protein destabilization IMP
IMP: Inferred from mutant phenotype
2129524 RGD
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
11786535 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
15951807 RGD
located in early endosome IDA
IDA: Inferred from direct assay
11786535 RGD
located in nucleus IDA
IDA: Inferred from direct assay
15951807 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase SIAH1

  • RING-type E3 ubiquitin transferase SIAH1

  • seven in absentia 1A

  • seven in absentia homolog 1

  • siah-1

  • siah-1a

Siah1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Siah1 Q920M9 Pclo Rattus norvegicus Q9JKS6
Anti Tag CoIP
23403927
Intra
Siah1 Q920M9 Bsn Rattus norvegicus O88778
Anti Tag CoIP
23403927
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108705 BI-3802 Inhibitor 99.27% Unkown
HY-W1124386 BG-DBCO 98.06% Unkown
HY-182399 BC-DXI-495 Inhibitor / Unkown
HY-RS12891 SIAH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Siah1 NCBI NCBI:6477