SH3RF1 - SH3 domain containing ring finger 1 Gene

Also Known as POSH; RNF142; SH3MD2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57630

About SH3RF1

Cytogenetic location: 4q32.3-q33 Genomic coordinates (GRCh38): 4:169,094,259-169,270,956 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 12 paralogues. Ubiquitous expression in thyroid (RPKM 11.9), stomach (RPKM 11.2) and 24 other tissues.

Summary

This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein Ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]

SH3RF1 Products (1)

mRNA Protein Name
NM_020870.4 NP_065921.2 E3 ubiquitin-protein ligase SH3RF1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20696164 GOA
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
20696164 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21586138 GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
21586138 GOA
involved in negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
21586138 GOA
involved in protein autoubiquitination IMP
IMP: Inferred from mutant phenotype
20696164 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
21586138 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH3RF1 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (12 - 52)

SH3_9

SH3_9: Variant SH3 domain (141 - 189)

SH3_9

SH3_9: Variant SH3 domain (203 - 255)

SH3_9

SH3_9: Variant SH3 domain (452 - 502)

SH3_9

SH3_9: Variant SH3 domain (837 - 886)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 888 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase SH3RF1

  • RING-type E3 ubiquitin transferase SH3RF1

SH3RF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SH3RF1 Q7Z6J0 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
SH3RF1 Q7Z6J0 RAC1 Homo sapiens P63000
Y2H Pooling
20936779
Intra
SH3RF1 Q7Z6J0 SIAH2 Homo sapiens O43255
Anti Tag CoIP
21586138
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12844 SH3RF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SH3RF1 VGNC VGNC:77259
Bos taurus SH3RF1 VGNC VGNC:34579
Mus musculus SH3RF1 MGD MGI:1913066
Felis catus SH3RF1 VGNC VGNC:65113
Canis familiaris SH3RF1 VGNC VGNC:46132
Rattus norvegicus SH3RF1 RGD RGD:735154
Others SH3RF1 NCBI