MIR133B - microRNA 133b Gene

Also Known as MIRN133B; mir-133b; miRNA133B

Species: Homo sapiens

Gene Type: ncRNA

Gene ID: 442890

About MIR133B

Cytogenetic location: 6p12.2 Genomic coordinates (GRCh38): 6:52,148,923-52,149,041 (from NCBI)

This gene has 1 transcript (splice variant), 129 orthologues and 2 paralogues.

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The encoded miRNA is considered a canonical myomiR and is important for normal cardiac and skeletal muscle development. It is additionally important for normal development in non-muscle tissues, and is abnormally expressed in a variety of cancers. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2017]

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	24443799	GOA
enables mRNA base-pairing translational repressor activity	IDA IDA: Inferred from direct assay	21351259	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	23296701	GOA
involved in miRNA-mediated post-transcriptional gene silencing	IDA IDA: Inferred from direct assay	21351259	GOA
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	24443799	GOA
involved in negative regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	26790441	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	24714873	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	24714873	GOA
involved in negative regulation of transporter activity	IDA IDA: Inferred from direct assay	28881788	GOA
involved in negative regulation of vascular endothelial cell proliferation	IDA IDA: Inferred from direct assay	26790441	GOA
acts upstream of negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane	IDA IDA: Inferred from direct assay	28881788	GOA
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	27412702	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Diseases

Diseases	Alias
Tongue Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Tongue
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Testicular Germ Cell Tumor	Male Germ Cell Tumor Testicular Teratoma TGCT Mgct Male Germ Cell Tumor, Somatic Spermatocytic Seminoma, Somatic Embryonal Cell Carcinoma Seminoma Spermatocytic Seminoma Germ Cell Tumors, Somatic Testicular Tumor, Somatic Non-Seminomatous Germ Cell Tumor Of Testis Non-Dysgerminomatous Germ Cell Tumor Of Testis Testicular Non Seminomatous Germ Cell Tumor Testicular Non-Dysgerminomatous Germ Cell Tumor Teratoma Of The Testis Endodermal Sinus Tumor Nonseminomatous Germ Cell Tumors Teratoma Testicular Germ Cell Tumor, Somatic Embryonal Carcinoma Cell Yolk Sac Tumor Malignant Testicular Non-Seminomatous Germ Cell Tumor Testicular Non-Seminomatous Germ Cell Tumor Teratoma Of Testis Nonseminomatous Germ Cell Tumor
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Psoriasis
Oral Squamous Cell Carcinoma	Mouth Squamous Cell Carcinoma Squamous Cell Carcinoma Of Mouth
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-W010737	Guanosine-5'-triphosphate disodium salt		99.58%	Phase 3
HY-12695B	Guanosine 5'-triphosphate trisodium salt hydrate	Inducer	95.0%	Phase 3

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12695	Guanosine 5'-triphosphate trisodium	Inducer	95.0%	Unkown
HY-RI00253	hsa-miR-133b inhibitor		97.15%	Unkown
HY-R00253	hsa-miR-133b mimic		/	Unkown
HY-R00253A	hsa-miR-133b agomir		/	Unkown
HY-R02666	mmu-miR-133b-5p mimic		/	Unkown
HY-R02666A	mmu-miR-133b-5p agomir		/	Unkown
HY-R04227	rno-miR-133b-5p mimic		/	Unkown
HY-R04227A	rno-miR-133b-5p agomir		/	Unkown
HY-RI00253A	hsa-miR-133b antagomir		/	Unkown
HY-RI02666	mmu-miR-133b-5p inhibitor		/	Unkown
HY-RI02666A	mmu-miR-133b-5p antagomir		/	Unkown
HY-RI04227	rno-miR-133b-5p inhibitor		/	Unkown
HY-RI04227A	rno-miR-133b-5p antagomir		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MIR133B	RGD	RGD:2325527
Mus musculus	MIR133B	MGD	MGI:3618720