MIR133B - microRNA 133b Gene

Homo sapiens

Also known as MIRN133B; mir-133b; miRNA133B

Gene ID: 442890 | Gene type: ncRNA

About MIR133B

Cytogenetic location: 6p12.2 Genomic coordinates (GRCh38): 6:52,148,923-52,149,041 (from NCBI)

This gene has 1 transcript (splice variant), 129 orthologues and 2 paralogues.

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The encoded miRNA is considered a canonical myomiR and is important for normal cardiac and skeletal muscle development. It is additionally important for normal development in non-muscle tissues, and is abnormally expressed in a variety of cancers. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2017]

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	24443799	GOA
enables mRNA base-pairing translational repressor activity	IDA IDA: Inferred from direct assay	21351259	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	23296701	GOA
involved in miRNA-mediated post-transcriptional gene silencing	IDA IDA: Inferred from direct assay	21351259	GOA
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	24443799	GOA
involved in negative regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	26790441	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	24714873	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	24714873	GOA
involved in negative regulation of transporter activity	IDA IDA: Inferred from direct assay	28881788	GOA
involved in negative regulation of vascular endothelial cell proliferation	IDA IDA: Inferred from direct assay	26790441	GOA
acts upstream of negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane	IDA IDA: Inferred from direct assay	28881788	GOA
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	27412702	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Diseases

Diseases

Alias

Tongue Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Tongue

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Testicular Germ Cell Tumor

Male Germ Cell Tumor	Testicular Teratoma
TGCT	Mgct
Male Germ Cell Tumor, Somatic	Spermatocytic Seminoma, Somatic
Embryonal Cell Carcinoma	Seminoma
Spermatocytic Seminoma	Germ Cell Tumors, Somatic
Testicular Tumor, Somatic	Non-Seminomatous Germ Cell Tumor Of Testis
Non-Dysgerminomatous Germ Cell Tumor Of Testis	Testicular Non Seminomatous Germ Cell Tumor
Testicular Non-Dysgerminomatous Germ Cell Tumor	Teratoma Of The Testis
Endodermal Sinus Tumor	Nonseminomatous Germ Cell Tumors
Teratoma Testicular	Germ Cell Tumor, Somatic
Embryonal Carcinoma Cell	Yolk Sac Tumor
Malignant Testicular Non-Seminomatous Germ Cell Tumor	Testicular Non-Seminomatous Germ Cell Tumor
Teratoma Of Testis	Nonseminomatous Germ Cell Tumor

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Psoriasis

Oral Squamous Cell Carcinoma

Mouth Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Mouth

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-W010737	Guanosine-5'-triphosphate disodium salt		99.58%	Phase 3
HY-12695B	Guanosine 5'-triphosphate trisodium salt hydrate	Inducer	95.0%	Phase 3

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12695	Guanosine 5'-triphosphate trisodium	Inducer	95.0%	Unkown
HY-RI00253	hsa-miR-133b inhibitor		97.15%	Unkown
HY-R00253	hsa-miR-133b mimic		/	Unkown
HY-R00253A	hsa-miR-133b agomir		/	Unkown
HY-R02666	mmu-miR-133b-5p mimic		/	Unkown
HY-R02666A	mmu-miR-133b-5p agomir		/	Unkown
HY-R04227	rno-miR-133b-5p mimic		/	Unkown
HY-R04227A	rno-miR-133b-5p agomir		/	Unkown
HY-RI00253A	hsa-miR-133b antagomir		/	Unkown
HY-RI02666	mmu-miR-133b-5p inhibitor		/	Unkown
HY-RI02666A	mmu-miR-133b-5p antagomir		/	Unkown
HY-RI04227	rno-miR-133b-5p inhibitor		/	Unkown
HY-RI04227A	rno-miR-133b-5p antagomir		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MIR133B	RGD	RGD:2325527
Mus musculus	MIR133B	MGD	MGI:3618720

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