En2 - engrailed homeobox 2 Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including embryonic brain development; negative regulation of neuron apoptotic process; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within nervous system development and positive regulation of transcription by RNA polymerase II. Located in membrane and nucleus. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]