STK26 - serine/threonine kinase 26 Gene

Also Known as MASK; MST4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51765

About STK26

Cytogenetic location: Xq26.2 Genomic coordinates (GRCh38): X:132,023,302-132,075,943 (from NCBI)

This gene has 5 transcripts (splice variants), 219 orthologues and 35 paralogues. Broad expression in endometrium (RPKM 22.0), bone marrow (RPKM 21.7) and 22 other tissues.

Summary

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by Caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

STK26 Products (3)

mRNA Protein Name
NM_001042452.2 NP_001035917.1 serine/threonine-protein kinase 26 isoform 3
NM_001042453.2 NP_001035918.1 serine/threonine-protein kinase 26 isoform 2
NM_016542.4 NP_057626.2 serine/threonine-protein kinase 26 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
11641781 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
11741893 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
11641781 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15037601 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
21561863 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
11641781 GOA
enables protein kinase activity IMP
IMP: Inferred from mutant phenotype
22797597 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to oxidative stress IDA
IDA: Inferred from direct assay
22291017 GOA
involved in cellular response to starvation IMP
IMP: Inferred from mutant phenotype
27807006 GOA
involved in intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
22291017 GOA
involved in microvillus assembly IDA
IDA: Inferred from direct assay
22797597 GOA
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
27807006 GOA
involved in protein autophosphorylation IMP
IMP: Inferred from mutant phenotype
22797597 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11641781 GOA
involved in regulation of apoptotic process IDA
IDA: Inferred from direct assay
11741893 GOA
Cellular Component GO Annotation Evidence References Source
part of FAR/SIN/STRIPAK complex IDA
IDA: Inferred from direct assay
18782753 GOA
located in Golgi apparatus IDA
IDA: Inferred from direct assay
15037601 GOA
located in Golgi-associated vesicle IDA
IDA: Inferred from direct assay
22797597 GOA
located in apical plasma membrane IDA
IDA: Inferred from direct assay
22797597 GOA
located in cell periphery IDA
IDA: Inferred from direct assay
22291017 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17360971 GOA
located in cytosol IDA
IDA: Inferred from direct assay
22797597 GOA
located in membrane IDA
IDA: Inferred from direct assay
27807006 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
22291017 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK26 Protein Structure

Pkinase

Pkinase: Protein kinase domain (24 - 274)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase 26

  • Mst3 and SOK1-related kinase

STK26 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STK26 Q9P289 STRIP1 Homo sapiens Q5VSL9
Anti Tag CoIP
18782753
Intra
STK26 Q9P289 STRIP1 Homo sapiens Q5VSL9
Pull Down
32707033
Intra
STK26 Q9P289 STRIP1 Homo sapiens Q5VSL9
Anti Tag CoIP
35271311
Intra
STK26 Q9P289 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
35271311
Intra
STK26 Q9P289 CTTNBP2NL Homo sapiens Q9P2B4
TAP
23455922
Intra
STK26 Q9P289 CTTNBP2NL Homo sapiens Q9P2B4
Anti Bait CoIP
18782753
Intra
STK26 Q9P289 CTTNBP2NL Homo sapiens Q9P2B4
Pull Down
32707033
Intra
STK26 Q9P289 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
18782753
Intra
STK26 Q9P289 CAB39 Homo sapiens Q9Y376
SPR
21423148
Intra
STK26 Q9P289 CAB39 Homo sapiens Q9Y376
Anti Tag CoIP
21423148
Intra
STK26 Q9P289 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Intra
STK26 Q9P289 STRN Homo sapiens O43815
Anti Bait CoIP
18782753
Intra
STK26 Q9P289 PDCD10 Homo sapiens Q9BUL8
TAP
23455922
Intra
STK26 Q9P289 PDCD10 Homo sapiens Q9BUL8
Pull Down
32707033
Intra
STK26 Q9P289 STRN3 Homo sapiens Q13033
Anti Bait CoIP
18782753
Intra
STK26 Q9P289 STRN Homo sapiens O43815
TAP
23455922
Intra
STK26 Q9P289 PDCD10 Homo sapiens Q9BUL8
Anti Tag CoIP
35271311
Intra
STK26 Q9P289 STRN3 Homo sapiens Q13033
TAP
23455922
Intra
STK26 Q9P289 PDCD10 Homo sapiens Q9BUL8
Y2H Array
31515488
Intra
STK26 Q9P289 STRN Homo sapiens O43815
Pull Down
32707033
Intra
STK26 Q9P289 STRN3 Homo sapiens Q13033
Pull Down
32707033
Intra
STK26 Q9P289 PDCD10 Homo sapiens Q9BUL8
Anti Bait CoIP
18782753
Intra
STK26 Q9P289 STRN3 Homo sapiens Q13033
Anti Tag CoIP
35271311
Intra
STK26 Q9P289 GOLGA2 Homo sapiens Q08379
Y2H
15037601
Intra
STK26 Q9P289 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
STK26 Q9P289 GOLGA2 Homo sapiens Q08379
Pull Down
32707033
Intra
STK26 Q9P289 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
STK26 Q9P289 GOLGA2 Homo sapiens Q08379
Anti Tag CoIP
35271311
Intra
STK26 Q9P289 GOLGA2 Homo sapiens Q08379
IF
15037601
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STK26 Proteins

Cat. No. Product Name Accession Purity
HY-P74741 MST4/STK26 Protein, Human (Active, sf9, GST) Q9P289-1 (M1-P416) ≥ 95%, as determined by reducing SDS-PAGE.

STK26 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83508 MST4 Antibody (YA3253) WB, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat
HY-P83508A MST4 Antibody (YA3253)(PBS only) WB, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Cerebral Cavernous Malformations 3

  • Cerebral Cavernous Malformation 3

  • CCM3

  • Cerebral Cavernous Malformations-3

  • Cavernous Angiomatous Malformations

  • Cavernous Hemangioma Of The Brain

  • Cerebral Capillary Malformations

  • Cerebral Cavernoma

  • Familial Cavernous Angioma

  • Cerebral Cavernous Malformations, Type 3
Cerebral Cavernous Malformations

  • Cerebral Cavernous Malformation

  • Cavernous Malformations Of Cns And Retina

  • Cerebral Cavernous Malformation 1

  • Cavernous Angiomatous Malformations

  • Cerebral Capillary Malformations

  • CCM

  • Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

  • Familial Cavernous Angioma

  • Cavernous Angioma

  • Familial Cerebral Cavernous Malformation

  • Cerebral Cavernous Malformations 1

  • Cavernous Angioma, Familial

  • Cam

  • Cerebral Cavernous Malformations-1

  • Cavernoma

  • Central Nervous System Cavernous Hemangioma

  • Cerebral Cavernous Hemangioma

  • Familial Cavernous Hemangioma

  • Familial Cavernous Malformation

  • Familial Cerebral Cavernous Angioma

  • Intracerebral Cavernous Hemangioma

  • CCM1

  • Cavernous Hemangioma Of The Brain

  • Cerebral Cavernoma

  • Cerebral Cavernous Malformations, Type 1

  • Hemangioma, Cavernous, Central Nervous System

  • Hemangioma, Cavernous

  • Angioma, Cavernous
Cerebrocostomandibular Syndrome

  • Cerebro-Costo-Mandibular Syndrome

  • CCMS

  • Rib Gap Defects With Micrognathia

  • Ccm Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13929 STK26 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20498 Stk26 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27006 Stk26 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta STK26 VGNC VGNC:81585
Mus musculus STK26 MGD MGI:1917665
Rattus norvegicus STK26 RGD RGD:1563568
Canis familiaris STK26 VGNC VGNC:46910
Felis catus STK26 VGNC VGNC:97648
Bos taurus STK26 VGNC VGNC:35392
Others STK26 NCBI