STRN3 - striatin 3 Gene

Also Known as SG2NA; S/G2NA; PPP2R6B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29966

About STRN3

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:30,893,804-31,026,379 (from NCBI)

This gene has 8 transcripts (splice variants), 212 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 11.4), fat (RPKM 8.6) and 25 other tissues.

Summary

Enables armadillo repeat domain binding activity; protein Phosphatase 2A binding activity; and small GTPase binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; nucleoplasm; and plasma membrane. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Apr 2022]

STRN3 Products (2)

mRNA Protein Name
NM_001083893.2 NP_001077362.1 striatin-3 isoform 1
NM_014574.4 NP_055389.3 striatin-3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables armadillo repeat domain binding IPI
IPI: Inferred from physical interaction
18502210 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18782753 GOA
enables protein phosphatase 2A binding IDA
IDA: Inferred from direct assay
18782753 GOA
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
18782753 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
30622739 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
25743393 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11570823 GOA
involved in negative regulation of hippo signaling IDA
IDA: Inferred from direct assay
30622739 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11570823 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11570823 GOA
Cellular Component GO Annotation Evidence References Source
part of FAR/SIN/STRIPAK complex IDA
IDA: Inferred from direct assay
18782753 GOA
located in Golgi apparatus IDA
IDA: Inferred from direct assay
11251078 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
18434427 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
11570823 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18434427 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
11251078 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STRN3 Protein Structure

Striatin

Striatin: Striatin family (64 - 197)

WD40

WD40: WD domain, G-beta repeat (470 - 508)

WD40

WD40: WD domain, G-beta repeat (524 - 561)

WD40

WD40: WD domain, G-beta repeat (580 - 614)

WD40

WD40: WD domain, G-beta repeat (714 - 751)

  • 0
  • 200
  • 400
  • 600
  • 797 a.a.
Protein Preferred Names Protein Names

striatin-3

  • cell cycle S/G2 nuclear autoantigen

STRN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STRN3 Q13033 STRN Homo sapiens O43815
Anti Tag CoIP
18782753
Intra
STRN3 Q13033 STRN Homo sapiens O43815
Anti Tag CoIP
35271311
Intra
STRN3 Q13033 STRN Homo sapiens O43815
Anti Tag CoIP
24366813
Intra
STRN3 Q13033 STRN Homo sapiens O43815
Anti Bait CoIP
18782753
Intra
STRN3 Q13033 STRN Homo sapiens O43815
Anti Tag CoIP
26496610
Intra
STRN3 Q13033 STRN Homo sapiens O43815
BioID
24255178
Intra
STRN3 Q13033 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
18782753
Intra
STRN3 Q13033 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
33961781
Intra
STRN3 Q13033 CTTNBP2NL Homo sapiens Q9P2B4
BioID
24255178
Intra
STRN3 Q13033 CTTNBP2NL Homo sapiens Q9P2B4
Anti Bait CoIP
18782753
Intra
STRN3 Q13033 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
24366813
Intra
STRN3 Q13033 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
26496610
Intra
STRN3 Q13033 MOB4 Homo sapiens Q9Y3A3-1
Anti Tag CoIP
33633399
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13967 STRN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus STRN3 RGD RGD:621827
Canis familiaris STRN3 VGNC VGNC:46946
Felis catus STRN3 VGNC VGNC:80830
Mus musculus STRN3 MGD MGI:2151064
Bos taurus STRN3 VGNC VGNC:35425
Macaca mulatta STRN3 VGNC VGNC:78127
Others STRN3 NCBI