KCNK10 - potassium two pore domain channel subfamily K member 10 Gene

Also Known as TREK2; TREK-2; K2p10.1; PPP1R97

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54207

About KCNK10

Cytogenetic location: 14q31.3 Genomic coordinates (GRCh38): 14:88,180,108-88,326,912 (from NCBI)

This gene has 4 transcripts (splice variants), 288 orthologues and 14 paralogues. Biased expression in brain (RPKM 1.7), duodenum (RPKM 1.4) and 8 other tissues.

Summary

The protein encoded by this gene belongs to the family of Potassium Channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]

KCNK10 Products (3)

mRNA Protein Name
NM_021161.5 NP_066984.1 potassium channel subfamily K member 10 isoform 1 precursor
NM_138317.3 NP_612190.1 potassium channel subfamily K member 10 isoform 2
NM_138318.3 NP_612191.1 potassium channel subfamily K member 10 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables mechanosensitive potassium channel activity IDA
IDA: Inferred from direct assay
38605031 GOA
enables outward rectifier potassium channel activity IDA
IDA: Inferred from direct assay
26919430 GOA
enables potassium ion leak channel activity IDA
IDA: Inferred from direct assay
26919430 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to arachidonate IDA
IDA: Inferred from direct assay
26919430 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNK10 Protein Structure

Ion_trans_2

Ion_trans_2: Ion channel (147 - 206)

Ion_trans_2

Ion_trans_2: Ion channel (244 - 323)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 538 a.a.
Protein Preferred Names Protein Names

potassium channel subfamily K member 10

  • 2P domain potassium channel TREK2

Related Diseases

Diseases Alias
Birk-Barel Syndrome

  • Birk-Barel Mental Retardation Dysmorphism Syndrome

  • BIBARS

  • Mental Retardation With Hypotonia And Facial Dysmorphism

  • Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome

  • Kcnk9 Imprinting Syndrome
Brain Glioblastoma Multiforme

  • Brain Glioblastoma

  • Glioblastoma Multiforme Of Brain

  • Glioblastoma Nos
Migraine With Aura

  • Classic Migraine

  • Migraine With Typical Aura

  • Migraine Accompagnée

  • Complicated Migraine

  • Classical Migraine

  • Acute Migraine With Aura
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W011235 Norfluoxetine hydrochloride 99.58% Unkown
HY-135556 Norfluoxetine 98.71% Unkown
HY-W011235S Norfluoxetine-d5 hydrochloride 99.30% Unkown
HY-135556AS Norfluoxetine-d5 / Unkown
HY-RS07153 KCNK10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-135556A Norfluoxetine oxalate / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta KCNK10 VGNC VGNC:73994
Felis catus KCNK10 VGNC VGNC:67919
Mus musculus KCNK10 MGD MGI:1919508
Canis familiaris KCNK10 VGNC VGNC:42270
Bos taurus KCNK10 VGNC VGNC:30466
Rattus norvegicus KCNK10 RGD RGD:619732
Others KCNK10 NCBI