SMARCA2 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 Gene

Also Known as BIS; BRM; SNF2; SWI2; hBRM; NCBRS; Sth1p; BAF190; SNF2L2; SNF2LA; hSNF2a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6595

About SMARCA2

Cytogenetic location: 9p24.3 Genomic coordinates (GRCh38): 9:2,015,347-2,193,624 (from NCBI)

This gene has 72 transcripts (splice variants), 213 orthologues, 30 paralogues and is associated with 5 phenotypes. Ubiquitous expression in ovary (RPKM 42.5), testis (RPKM 29.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]

SMARCA2 Products (7)

mRNA	Protein	Name
NM_001289396.1	NP_001276325.1	probable global transcription activator SNF2L2 isoform a
NM_001289397.2	NP_001276326.1	probable global transcription activator SNF2L2 isoform c
NM_001289398.2	NP_001276327.1	probable global transcription activator SNF2L2 isoform d
NM_001289399.1	NP_001276328.1	probable global transcription activator SNF2L2 isoform e precursor
NM_001289400.1	NP_001276329.1	probable global transcription activator SNF2L2 isoform f precursor
NM_003070.5	NP_003061.3	probable global transcription activator SNF2L2 isoform a
NM_139045.4	NP_620614.2	probable global transcription activator SNF2L2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12065415	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	17984088	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	17984088	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12065415	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	12065415	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	14660596	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17984088	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	8208605	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15774904	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SWI/SNF complex	IDA IDA: Inferred from direct assay	11078522	GOA
located in chromatin	IDA IDA: Inferred from direct assay	12065415	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17984088	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMARCA2 Protein Structure

QLQ

HSA

BRK

SNF2_N

Helicase_C

SnAC

Bromodomain

0
300
600
900
1200
1500
1590 a.a.

Protein Preferred Names	Protein Names
probable global transcription activator SNF2L2	ATP-dependent helicase SMARCA2

SMARCA2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SMARCA2	P51531	MECP2	Homo sapiens	P51608	Crosslink	15696166
Intra	SMARCA2	P51531	MECP2	Homo sapiens	P51608	Anti Bait CoIP	15696166
Intra	SMARCA2	P51531	ARID1A	Homo sapiens	O14497	Anti Tag CoIP	12200431
Intra	SMARCA2	P51531	ARID1B	Homo sapiens	Q8NFD5	Pull Down	12200431
Intra	SMARCA2	P51531	SDCBP	Homo sapiens	O00560	Validated Y2H	25910212
Cross	SMARCA2	P51531	tat	Human immunodeficiency virus	P04326	Pull Down	16601680
Cross	SMARCA2	P51531	tat	Human immunodeficiency virus	P04326	Anti Tag CoIP	16601680

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SMARCA2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7985	SMARCA2 Protein, Human (P.pastoris, His)	P51531 (S700-F1216)	≥ 90%, as determined by reducing SDS-PAGE.

SMARCA2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83496	SMARCA2 Antibody (YA3241)	WB, IHC-P, ICC/IF, FC	Human, Mouse
HY-P83496A	SMARCA2 Antibody (YA3241)(PBS only)	WB, IHC-P, ICC/IF, FC	Human, Mouse

Related Diseases

Diseases	Alias
Nicolaides-Baraitser Syndrome	NCBRS Nbs Sparse Hair And Mental Retardation Sparse Hair And Intellectual Disability Intellectual Disability-Sparse Hair-Brachydactyly Syndrome Nicolaides Baraitser Syndrome
Blepharophimosis-Impaired Intellectual Development Syndrome	BIS
Ohdo Syndrome	Young Simpson Syndrome Ohdo Blepharophimosis Syndrome Blepharophimosis Syndrome Ohdo Type Blepharophimosis Intellectual Disability Syndromes Bmrs Blepharophimosis-Intellectual Disability Syndrome Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth Sbbys Syndrome Say Barber Biesecker Young-Simpson Syndrome Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type Bmrs, Ohdo Type Blepharophimosis Syndrome, Ohdo Type Ohdo-Madokoro-Sonoda Syndrome Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type Blepharophimosis - Intellectual Disability Syndrome
Blepharophimosis
Pituitary Stalk Interruption Syndrome	Ectopic Neurohypophysis Psis
Clark-Baraitser Syndrome	CLABARS Baraitser Syndrome Autosomal Dominant Intellectual Disability 49 Mental Retardation, Autosomal Dominant 49, Formerly Mrd49, Formerly Intellectual Developmental Disorder, Autosomal Dominant 49 Autosomal Dominant Mental Retardation 49 Intellectual Disability, Tall Stature, Obesity, Macrocephaly And Typical Facial Features Mrd49 Progeria Short Stature Pigmented Nevi
Schimke Immunoosseous Dysplasia	Schimke Immuno-Osseous Dysplasia SIOD Immunoosseous Dysplasia, Schimke Type Schimke Syndrome Immunoosseous Dysplasia Schimke Type Spondyloepiphyseal Dysplasia - Nephrotic Syndrome Spondyloepiphyseal Dysplasia Nephrotic Syndrome Spondyloepiphyseal Dysplasia-Nephrotic Syndrome
Smarca4-Deficient Sarcoma Of Thorax	Smarca4-Dts Smarca4-Deficient Thoracic Sarcoma
Alpha-Thalassemia Myelodysplasia Syndrome	ATMDS Acquired Hemoglobin H Disease Alpha-Thalassemia Myelodysplasia Syndrome, Somatic Acquired Hbh Disease Alpha-Thalassemia-Myelodysplastic Syndrome Hemoglobin H Disease, Acquired Acquired Alpha-Thalassemia With Myelodysplastic Syndrome Hemoglobin H Disease Acquired Thalassemia, Alpha, Myelodysplasia Syndrome, Somatic
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Alpha Thalassemia-X-Linked Intellectual Disability Syndrome	Atr-X Syndrome Atr, Nondeletion Type Alpha-Thalassemia X-Linked Intellectual Disability Syndrome Atrx Syndrome Alpha-Thalassemia/Mental Retardation Syndrome Nondeletion Type Alpha Thalassemia Intellectual Disability Syndrome, Nondeletion Type, X-Linked X-Linked Alpha-Thalassemia/Intellectual Disability Syndrome Xlmr Hypotonic Face Syndrome Alpha Thalassemia X-Linked Intellectual Disability Syndrome Alpha Thalassemia X-Linked Mental Retardation Syndrome Alpha Thalassemia/Mental Retardation, X-Linked Alpha-Thalassemia X-Linked Mental Retardation Syndrome Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type X-Linked Alpha-Thalassemia/Mental Retardation Syndrome Xlmr-Hypotonic Face Syndrome Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type, X-Linked
Nasal Cavity Cancer	Nasal Cavity Carcinoma Malignant Neoplasm Of Nasal Cavities Malignant Tumor Of The Nasal Cavity Cancer Of Nasal Cavity Carcinoma Of Nasal Cavity Malignant Neoplasm Of Nasal Cavity Neoplasm Of Nasal Cavity
Coffin-Siris Syndrome 1	Coffin-Siris Syndrome Fifth Digit Syndrome Css CSS1 Mrd12 Mental Retardation, Autosomal Dominant 12 Hhid Dwarfism-Onychodysplasia Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features Autosomal Dominant Mental Retardation 12 Short Stature-Onychodysplasia. Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx Mental Retardation With Hypoplastic Fifth Fingernails And Toenails Short Stature-Onychodysplasia Coffin-Siris Syndrome, Type 1 Mental Retardation, Autosomal Dominant, Type 12
Autosomal Dominant Intellectual Developmental Disorder	Autosomal Dominant Mental Retardation Autosomal Dominant Non-Syndromic Mental Retardation Autosomal Dominant Non-Syndromic Intellectual Disability Mental Retardation, Autosomal Dominant
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs
Basan Syndrome	Adermatoglyphia With Congenital Facial Milia And Acral Blisters, Digital Contractures, And Nail Abnormalities Ectodermal Dysplasia, Absent Dermatoglyphic Pattern, Changes In Nails, And Simian Crease Baird Syndrome Absence Of Fingerprints-Congenital Milia Syndrome Absence Of Fingerprints Congenital Milia Absence Of Dermatoglyphics Congenital Milia Absence Of Dermatoglyphics-Congenital Milia Syndrome Basan-Baird Syndrome BSNS Adermatoglyphia, Congenital Facial Milia, Acral Blisters, Digital Contractures, Nail Abnormalities
Floating-Harbor Syndrome	FLHS Fhs Pelletier-Leisti Syndrome Short Stature With Delayed Bone Age, Expressive Language Delay, A Triangular Face With A Prominent Nose And Deep-Set Eyes Leisti-Hollander-Rimoin Syndrome
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Ovarian Small Cell Carcinoma	Small Cell Carcinoma Of The Ovary Scco Small Cell Ovarian Carcinoma
Bartholin'S Gland Adenoid Cystic Carcinoma	Bartholin Gland Adenoid Cystic Carcinoma
Schizophrenia 7	SCZD7 Schizophrenia Susceptibility Locus, Chromosome 13q-Related Schizophrenia 7 With Or Without An Affective Disorder
Sinonasal Undifferentiated Carcinoma	Highly Aggressive Undifferentiated Carcinoma Of The Nasal Cavity And Paranasal Sinuses Snuc
Rhabdoid Cancer	Rhabdoid Tumor Malignant Rhabdoid Tumor Malignant Rhabdoid Tumour Rhabdoid Sarcoma Rhabdoid Tumor Predisposition Syndrome 1 Rhabdoid Tumor Predisposition Syndrome 2 Atypical Teratoid Rhabdoid Tumor Brain Tumor, Posterior Fossa, Of Infancy, Familial Atypical Teratoid/Rhabdoid Tumor
Small-Cell Carcinoma Of The Ovary Of Hypercalcemic Type	Hypercalcemic Type Ovarian Small Cell Carcinoma Small Cell Carcinoma Of The Ovary, Hypercalcemic Type Ovarian Small Cell Carcinoma, Hypercalcemic Type
Cartilage-Hair Hypoplasia	Metaphyseal Chondrodysplasia, Mckusick Type CHH Mckusick Type Metaphyseal Chondrodysplasia Metaphyseal Dysplasia Without Hypotrichosis Cartilage Hair Hypoplasia Like Syndrome Metaphyseal Chondrodysplasia Mckusick Type Chhv Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency Cartilage-Hair Syndrome Mckusick'S Metaphyseal Chondrodysplasia Syndrome Metaphyseal Chondrodysplasia, Recessive Type Autosomal Recessive Metaphyseal Chondrodysplasia
Adenoid Cystic Carcinoma	Adenocystic Carcinoma Cribriform Carcinoma Cylindroma Carcinoma Adenoid Cystic Carcinoma, Adenoid Cystic Adenoid Cystic Carcinoma Of Salivary Gland Eccrine Dermal Cylindroma Carcinoma, Cribriform
Large Cell Carcinoma With Rhabdoid Phenotype	Large Cell Lung Carcinoma With Rhabdoid Phenotype
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Syndromic X-Linked Intellectual Disability Nascimento Type	Mental Retardation, X-Linked Syndromic, Nascimento-Type X-Linked Intellectual Disability-Nail Dystrophy-Seizures Syndrome
Ovarian Endometrial Cancer	Endometrioid Neoplasm Of Ovary Malignant Ovarian Endometrioid Tumor Ovarian Endometrioid Neoplasm
Juvenile Type Testicular Granulosa Cell Tumor	Juvenile Granulosa Cell Tumor Juvenile Granulosa Cell Tumour Juvenile Type Granulosa Cell Neoplasm Juvenile Type Granulosa Cell Tumor Juvenile Type Granulosa Cell Tumour Juvenile Type Testicular Granulosa Cell Tumour
Testicular Granulosa Cell Tumor	Granulosa Cell Tumor Of Testis Granulosa Cell Tumour Of Testis Testicular Granulosa Cell Tumour
Brachydactyly
Atypical Neurofibroma
Paranasal Sinus Cancer	Paranasal Sinus Adenoid Cystic Carcinoma Paranasal Sinus Mucoepidermoid Carcinoma Paranasal Sinus Squamous Cell Carcinoma Paranasal Sinus Neoplasms Adenoid Cystic Carcinoma Of Accessory Sinus Adenoid Cystic Carcinoma Of Paranasal Sinus Epidermoid Carcinoma Of The Paranasal Sinus Mucoepidermoid Carcinoma Of Accessory Sinus Paranasal Sinus Adenocarcinoma Squamous Cell Carcinoma Of Paranasal Sinus Paranasal Sinus Neoplasm Adenocarcinoma Of Accessory Sinus
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome	Icf Syndrome Immunodeficiency Syndrome, Variable Ciid Centromeric Instability, Immunodeficiency Syndrome Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16 Icf
Non-Syndromic X-Linked Intellectual Disability 93	Mrx93 X-Linked Mental Retardation With Macrocephaly
Ovarian Clear Cell Carcinoma	Clear-Cell Ovarian Carcinoma
Rett Syndrome	Atypical Rett Syndrome RTT Rett Disorder Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Preserved Speech Variant Rett Syndrome, Atypical Rett'S Disorder Rett Syndrome Variant Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Cerebroatrophic Hyperammonemia Rett Like Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Bladder Urothelial Carcinoma	Bladder Transitional Cell Carcinoma Transitional Cell Carcinoma Of Bladder Transitional Cell Carcinoma Of The Bladder Urinary Bladder Urothelial Carcinoma Urothelial Bladder Carcinoma Carcinoma Transitional Cell Bladder Tcc - [Transitional Cell Carcinoma] Of Bladder
Chromosome 16p13.3 Deletion Syndrome, Proximal	Rubinstein-Taybi Syndrome Broad Thumb-Hallux Syndrome Chromosome 16p13.3 Deletion Syndrome Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion Rubinstein Syndrome Broad Thumbs-Halluces Syndrome Rsts Rubinstein-Taybi Deletion Syndrome Rsts Deletion Syndrome Proximal Chromosome 16p13.3 Deletion Syndrome 16p13.3 Deletion Syndrome Broad Thumbs And Great Toes, Characteristic Facies, And Intellectual Disability Rts
Schizoaffective Disorder	Schizo-Affective Psychosis Schizo-Affective Type Schizophrenia Schizoaffective Psychosis Schizoaffective Schizophrenia Schizophrenia, Schizo-Affective Type Schizophreniform Psychosis, Affective Type
Spondyloepimetaphyseal Dysplasia	Dysplasia, Spondyloepimetaphyseal
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome
Neurilemmomatosis	Schwannomatosis Neurofibromatosis Type 3 Nf3 Neurilemmomatosis Congenital Cutaneous Neurinomatosis Congenital Cutaneous Neurilemmomatosis Multiple Neurilemmomas Multiple Schwannomas Neurilemmomatosis, Congenital Cutaneous Schwannomatosis 1 Neurofibromatosis 3 Mixed Central And Peripheral Neurofibromatosis Nf3 - [Neurofibromatosis Type 3]
Borjeson-Forssman-Lehmann Syndrome	BFLS Borj Borjeson Syndrome Mrxsbfl Intellectual Deficiency-Epilepsy-Endocrine Disorders Syndrome Intellectual Disability-Epilepsy-Endocrine Disorders Syndrome Mental Retardation, X-Linked, Syndromic, Borjeson-Forssman-Lehmann Type Mental Retardation, Epilepsy, And Endocrine Disorders Mental Retardation, Epilepsy, And Endocrine Disorder Syndromic X-Linked Mental Retardation Borjeson-Forssman-Lehmann Type Mental Deficiency, Epilepsy And Endocrine Disorders Boerjeson-Forssman-Lehmann Syndrome Borjeson-Forssman Syndrome Mental Deficiency-Epilepsy- Endocrine Disorders
Schizophrenia 12	Sczd12 Schizophrenia Susceptibility Locus, Chromosome 1p-Related
Atypical Teratoid Rhabdoid Tumor	Rhabdoid Tumor Predisposition Syndrome Rtps Atypical Teratoid/Rhabdoid Tumor Rhabdoid Predisposition Syndrome Familial Posterior Fossa Brain Tumor Of Infancy Familial Rhabdoid Tumor At/Rt Atypical Teratoid Rhabdoid Tumour Atypical Teratoid/Rhabdoid Tumour Rhabdoid Tumor Of The Cns Rhabdoid Tumour Of The Cns Familial Posterior Fossa Brain Tumor Syndrome Hereditary Swi/Snf Deficiency Syndrome Atrt
Cockayne Syndrome B	Cockayne Syndrome Type 2 Cockayne Syndrome, Type B Cockayne Syndrome Type Ii CSB Cockayne Syndrome 2 Cockayne Syndrome Type B Ckn2 Cockayne Syndrome, Type Ii
Familial Isolated Trichomegaly	Long Eyelashes Tcmgly
Charge Syndrome	Charge Association Hall-Hittner Syndrome Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies Hhs Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome CHARGES
Uv-Sensitive Syndrome	Uvss Uv Sensitive Syndrome Ultraviolet Sensitive Syndrome
Developmental And Epileptic Encephalopathy 14	Malignant Migrating Partial Seizures Of Infancy Eiee14 Epilepsy Of Infancy With Migrating Focal Seizures Mmpsi DEE14 Epileptic Encephalopathy, Early Infantile, 14 Early Infantile Epileptic Encephalopathy 14 Malignant Migrating Partial Epilepsy Of Infancy Migrating Partial Epilepsy Of Infancy Migrating Partial Seizures Of Infancy Mmpei Mpei Mpsi Malignant Migrating Focal Seizures Of Infancy Migrating Partial Seizures In Infancy Developmental And Epileptic Encephalopathy, 14 Encephalopathy, Epileptic, Early Infantile, Type 14
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Primary Hyperoxaluria	Hyperoxaluria Hyperoxaluria, Primary Oxalosis Primary Oxalosis Congenital Oxaluria D-Glycerate Dehydrogenase Deficiency Glyceric Aciduria Glycolic Aciduria Hepatic Agt Deficiency Oxaluria, Primary Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Primary Oxaluria Hyperoxaluria Primary Primary Hyperoxaluria Type 2 Primary Hyperoxaluria, Type I
Hypertrichosis
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-159607	PRT3789	Degrader	98.08%	Phase 2

Pre-clinical Phase

Bioactive Molecules (33)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145388	AU-15330	Degrader	99.89%	Unkown
HY-128359	ACBI1	Degrader	99.92%	Unkown
HY-44012	SMARCA-BD ligand 1 for PROTAC	Ligand	99.07%	Unkown
HY-44012B	SMARCA-BD ligand 1 for PROTAC hydrochloride	Ligand	99.24%	Unkown
HY-44012A	SMARCA-BD ligand 1 for PROTAC dihydrochloride	Ligand	98.08%	Unkown
HY-46618	SMARCA2/4-ligand-8	Ligand	/	Unkown
HY-170824	SMD-3236	Degrader	/	Unkown
HY-185075	FHD-909	Inhibitor	/	Unkown
HY-168237	SMARCA2 ligand-10	Ligand	/	Unkown
HY-162814	SMARCA2/4-ligand-3	Ligand	/	Unkown
HY-169280	PXR Ligand 2		/	Unkown
HY-170354	SMARCA2/4-ligand-4	Ligand	/	Unkown
HY-161885	SMARCA2/4-IN-4	Inhibitor	/	Unkown
HY-170349	SMARCA2 ligand-11	Ligand	/	Unkown
HY-163949	SMARCA2/4-IN-3	Inhibitor	/	Unkown
HY-44824	SMARCA2 ligand-13	Ligand	/	Unkown
HY-180960	NEP202	Degrader	/	Unkown
HY-171765	SMARCA2/4-ligand-6	Ligand	/	Unkown
HY-178225	PROTAC SMARCA2/4 degrader-39	Degrader	/	Unkown
HY-168248	BRM/BRG1 ligand 2	Ligand	/	Unkown
HY-181909	PROTAC SMARCA2 degrader-36	Degrader	/	Unkown
HY-153425	PROTAC SMARCA2/4 degrader-41	Degrader	/	Unkown
HY-168230	SMARCA2 ligand-9	Ligand	/	Unkown
HY-180931	PROTAC A515	Degrader	/	Unkown
HY-170817	SMI-1074	Inhibitor	/	Unkown
HY-181910	SMARCA2 ligand-19	Ligand	/	Unkown
HY-169487	SMARCA2 ligand-12		/	Unkown
HY-180932	SMARCA2 ligand-17	Ligand	/	Unkown
HY-176871	PROTAC SMARCA2 degrader-35	Degrader	/	Unkown
HY-168252	BRM/BRG1 ligand 3	Ligand	/	Unkown
HY-172446	SMARCA2/4-ligand-5		/	Unkown
HY-159472	SMARCA2/4-ligand-1	Inhibitor	/	Unkown
HY-W539427	BRM/BRG1 ligand 1	Ligand	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SMARCA2	VGNC	VGNC:77647
Mus musculus	SMARCA2	MGD	MGI:99603
Rattus norvegicus	SMARCA2	RGD	RGD:1302988
Bos taurus	SMARCA2	VGNC	VGNC:34986
Canis familiaris	SMARCA2	VGNC	VGNC:46529
Felis catus	SMARCA2	VGNC	VGNC:65463
Others	SMARCA2	NCBI