SMARCA2 Protein, Human (P.pastoris, His)
SMARCA2 Protein, Human(P.pastoris, His) is a subunit of the Switch/Sucrose non-fermenting (SWI/SNF) complex, which play an important role in chromatin remodeling and regulation of downstream gene expression in neural development.
- Species: Human
- Source: P. pastoris
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Description
SMARCA2 Protein, Human(P.pastoris, His) is a subunit of the Switch/Sucrose non-fermenting (SWI/SNF) complex, which play an important role in chromatin remodeling and regulation of downstream gene expression in neural development.
Background
SMARCA2 is located on chromosome 9p24.3, and it encodes a component of SWI/SNF complexes. The SMARCA2 protein is a subunit of the SWI/SNF complexes which participate in chromatin remodeling in an ATPase-dependent manner[1]. SMARCA2 also shows frequent alterations in rhabdoid tumors, ovarian clear cell carcinomas (OCCCs), and small-cell carcinoma of the ovary, hyper-calcemic type (SCCOHT)[2].
Technical Parameters
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Species Human
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Source P. pastoris
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Tag N-6*His
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Accession
P51531 (S700-F1216)
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Molecular Construction
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N-term
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6*His
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SMARCA2 (S700-F1216)
Accession # P51531 -
C-term
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Protein Length
Partial
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Synonyms
SMARCA2; Brahma Homolog; Prev. SNF2L2; SAMRCA2; HBRM; BAF190B; BRM; CDNA FLJ59976, Highly Similar To Probable Global Transcription Activator SNF2L2; SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2; CDNA FL
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AA Sequence
SYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAF
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Predicted Molecular Mass
61.7 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (264 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Atsushi Kihara, et al. Infrequent loss of SMARCA4, SMARCA2, and SMARCB1 expression in uterine mesenchymal tumors. Hum Pathol. 2021 Jul 13;116:12-21. [Content Brief]
[2]. Marie-Isabelle Glückstein, et al. Comprehensive Immunohistochemical Study of the SWI/SNF Complex Expression Status in Gastric Cancer Reveals an Adverse Prognosis of SWI/SNF Deficiency in Genomically Stable Gastric Carcinomas. Cancers (Basel). 2021 Aug 2;13(15):3894. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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