STX3 - syntaxin 3 Gene

Also Known as MVID2; STX3A; DIAR12; RDMVID

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6809

About STX3

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:59,754,188-59,805,878 (from NCBI)

This gene has 8 transcripts (splice variants), 271 orthologues, 12 paralogues and is associated with 3 phenotypes. Ubiquitous expression in colon (RPKM 9.8), duodenum (RPKM 8.8) and 25 other tissues.

Summary

The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

STX3 Products (2)

mRNA	Protein	Name
NM_001178040.2	NP_001171511.1	syntaxin-3 isoform 2
NM_004177.5	NP_004168.1	syntaxin-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18588921	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in organelle membrane fusion	IMP IMP: Inferred from mutant phenotype	24726755	GOA
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	21720706	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21720706	GOA
involved in positive regulation of chemotaxis	IMP IMP: Inferred from mutant phenotype	21720706	GOA
involved in positive regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	21720706	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	21720706	GOA
involved in regulation of gene expression	IDA IDA: Inferred from direct assay	29475951	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16339081	GOA
located in azurophil granule	IDA IDA: Inferred from direct assay	18588921	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	15576373	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	21720706	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21720706	GOA
is active in presynapse	IDA IDA: Inferred from direct assay	27662481	GOA
is active in presynapse	IMP IMP: Inferred from mutant phenotype	27662481	GOA
located in specific granule	IDA IDA: Inferred from direct assay	18588921	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX3 Protein Structure

Syntaxin

SNARE

0
100
200
289 a.a.

Protein Preferred Names	Protein Names
syntaxin-3	syntaxin 3A

STX3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STX3	Q13277	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	STX3	Q13277	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	STX3	Q13277	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	STX3	Q13277	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	RMDN3	Homo sapiens	Q96TC7	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	RMDN3	Homo sapiens	Q96TC7	Validated Y2H	32296183
Intra	STX3	Q13277	RMDN3	Homo sapiens	Q96TC7	Y2H Array	32296183
Intra	STX3	Q13277	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	STX3	Q13277	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	STX3	Q13277	TMPPE	Homo sapiens	Q6ZT21	Validated Y2H	32296183
Intra	STX3	Q13277	TMPPE	Homo sapiens	Q6ZT21	Y2H Array	32296183
Intra	STX3	Q13277	TMPPE	Homo sapiens	Q6ZT21	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	STX3	Q13277	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	FXYD3	Homo sapiens	Q14802-3	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	FXYD3	Homo sapiens	Q14802-3	Validated Y2H	32296183
Intra	STX3	Q13277	FXYD3	Homo sapiens	Q14802-3	Y2H Array	32296183
Intra	STX3	Q13277	ZDHHC15	Homo sapiens	Q96MV8	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	ZDHHC15	Homo sapiens	Q96MV8	Validated Y2H	32296183
Intra	STX3	Q13277	ZDHHC15	Homo sapiens	Q96MV8	Y2H Array	32296183
Intra	STX3	Q13277	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	STX3	Q13277	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	STX3	Q13277	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	STX3	Q13277	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	STX3	Q13277	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	STX3	Q13277	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	STX3	Q13277	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	STX3	Q13277	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	STX3	Q13277	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	STX3	Q13277	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	STX3	Q13277	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	STX3	Q13277	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	STX3	Q13277	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	STX3	Q13277	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	STX3	Q13277	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	ZFYVE9	Homo sapiens	O95405	Anti Tag CoIP	17693260
Intra	STX3	Q13277	ZFYVE9	Homo sapiens	O95405	Pull Down	17693260
Intra	STX3	Q13277	MFSD14B	Homo sapiens	Q5SR56	Validated Y2H	32296183
Intra	STX3	Q13277	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	STX3	Q13277	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	MANBAL	Homo sapiens	Q9NQG1	Validated Y2H	32296183
Intra	STX3	Q13277	MANBAL	Homo sapiens	Q9NQG1	Y2H Array	32296183
Intra	STX3	Q13277	MANBAL	Homo sapiens	Q9NQG1	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	NAPB	Homo sapiens	Q9H115	Y2H Array	25416956
Intra	STX3	Q13277	NAPB	Homo sapiens	Q9H115	Validated Y2H	32296183
Intra	STX3	Q13277	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	STX3	Q13277	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	STX3	Q13277	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	33961781
Intra	STX3	Q13277	SNAP29	Homo sapiens	O95721	Y2H Array	32296183
Intra	STX3	Q13277	SNAP29	Homo sapiens	O95721	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	MMGT1	Homo sapiens	Q8N4V1	Validated Y2H	32296183
Intra	STX3	Q13277	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	STX3	Q13277	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	STX3	Q13277	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	STX3	Q13277	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	STX3	Q13277	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	STX3	Q13277	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	STX3	Q13277	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	STX3	Q13277	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	STX5	Homo sapiens	Q13190	Anti Tag CoIP	33961781
Intra	STX3	Q13277	STX5	Homo sapiens	Q13190	Y2H Array	32296183
Intra	STX3	Q13277	STX5	Homo sapiens	Q13190	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	COQ9	Homo sapiens	O75208	Y2H Array	32296183
Intra	STX3	Q13277	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	STX3	Q13277	STX4	Homo sapiens	Q12846	Y2H Array	32296183
Intra	STX3	Q13277	STX4	Homo sapiens	Q12846	Validated Y2H	25416956
Intra	STX3	Q13277	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	STX3	Q13277	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	STX3	Q13277	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	STX3	Q13277	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	STX3	Q13277	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	STX3	Q13277	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	STX3	Q13277	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	STX3	Q13277	CYB561	Homo sapiens	P49447	Y2H Array	32296183
Intra	STX3	Q13277	CYB561	Homo sapiens	P49447	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	EBAG9	Homo sapiens	O00559	Y2H Prey Pooling	32296183
Intra	STX3	Q13277	EBAG9	Homo sapiens	O00559	Y2H Array	32296183
Intra	STX3	Q13277	MSMO1	Homo sapiens	Q15800	Y2H Array	32296183
Intra	STX3	Q13277	MSMO1	Homo sapiens	Q15800	Validated Y2H	32296183
Intra	STX3	Q13277	MSMO1	Homo sapiens	Q15800	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STX3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73622	Syntaxin-3 Protein, Human (His)	Q13277 (M1-N289)	≥ 90%, as determined by reducing SDS-PAGE.

STX3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82357	Syntaxin 3 Antibody (YA2102)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Retinal Dystrophy And Microvillus Inclusion Disease	RDMVID
Diarrhea 12, With Microvillus Atrophy	DIAR12 Microvillus Inclusion Disease 2 Mvid2
Microvillus Inclusion Disease	Congenital Microvillous Atrophy Intractable Diarrhea Of Infancy Congenital Familial Protracted Diarrhea With Enterocyte Brush-Border Abnormalities Davidson Disease Microvillous Inclusion Disease Congenital Microvillus Atrophy Mvid Diarrhea 2 With Microvillus Atrophy Mvd Congenital Familial Protracted Diarrhea Davidson'S Disease Familial Enteropathy, Microvillus Microvillus Atrophy, Congenital Congenital Enteropathy Familial Protracted Enteropathy Microvillous Atrophy Microvillus Atrophy With Diarrhea 2 Idi
Congenital Diarrhea
Secretory Diarrhea
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Tetanus	Lockjaw Clostridial Tetanus Infection Due To Clostridium Tetani Lock-Jaw
Retinitis Pigmentosa 77	RP77 Retinitis Pigmentosa, Type 77
Familial Hemophagocytic Lymphohistiocytosis 5	Fhl5 Hlh5 Hplh5 Lymphohistiocytosis, Hemophagocytic, Familial, Type 5
Diarrhea 4, Malabsorptive, Congenital	Enteric Anendocrinosis Congenital Malabsorptive Diarrhea 4 DIAR4 Congenital Malabsorptive Diarrhea Due To Paucity Of Enteroendocrine Cells Congenital Malabsorptive Diarrhoea 4 Congenital Malabsorptive Diarrhoea Due To Paucity Of Enteroendocrine Cells Diarrhea, Type 4, Malabsorptive, Congenital
Hemophagocytic Lymphohistiocytosis, Familial, 4	Familial Hemophagocytic Lymphohistiocytosis 4 FHL4 Hplh4 Hlh4 Lymphohistiocytosis, Hemophagocytic, Familial, Type 4
Type 1 Diabetes Mellitus 10	Diabetes Mellitus, Insulin-Dependent, 10 IDDM10 Insulin-Dependent Diabetes Mellitus 10 Diabetes, Mellitus, Insulin-Dependent, Susceptibility To, 10 T1D10 Diabetes, Mellitus, Insulin-Dependent 10 Diabetes Mellitus, Insulin-Dependent, Type 10
Diarrhea 5, With Tufting Enteropathy, Congenital	Congenital Diarrhea 5 With Tufting Enteropathy Congenital Tufting Enteropathy DIAR5 Cte Intestinal Epithelial Cell Dysplasia Tufting Enteropathy Ied Intestinal Epithelial Dysplasia Enteropathy, Congenital Tufting Congenital Diarrhoea 5 With Tufting Enteropathy Congenital Familial Intractable Diarrhea With Epithelial Or Epithelium Abnormalities Congenital Familial Intractable Diarrhoea With Epithelial Or Epithelium Abnormalities Congenital Enteropathy Congenital Familial Intractable Diarrhea With Enterocytes Assembly Abnormalities Non-Syndromic Congenital Tufting Enteropathy Diarrhea, Type 5, With Tufting Enteropathy, Congenital Intestinal Intraepithelial Neoplasia
Gastrointestinal Defects And Immunodeficiency Syndrome 1	Familial Intestinal Polyatresia Syndrome Fipa Gastrointestinal Defects And Immunodeficiency Syndrome Multiple Gastrointestinal Atresias Familial Isolated Pituitary Adenoma Intestinal Atresia, Multiple Multiple Intestinal Atresia GIDID1 Multiple Intestinal Atresia And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency Minat Gidid Meddra:10028210 Familial Isolated Pituitary Adenoma Syndrome Intestinal Atresia Multiple Combined Immunodeficiency-Enteropathy Spectrum Cid-Mia/Early-Onset Ibd Intestinal Atresia, Multiple And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency Mia Gastrointestinal Defect And Immunodeficiency Syndrome Pituitary Adenoma Predisposition Pituitary Adenoma, Familial Isolated
Hemophagocytic Lymphohistiocytosis	Lymphohistiocytosis, Hemophagocytic Haemophagocytic Syndrome Lymphohistiocytosis Hemophagocytic Hemophagocytic Syndrome Familial Hemophagocytic Lymphocytosis Histiocytoses Of Mononuclear Phagocytes Haemophagocytic Lymphohistiocytosis Nos
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13983	STX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21438	Stx3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27956	Stx3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	STX3	VGNC	VGNC:65813
Rattus norvegicus	STX3	RGD	RGD:621005
Canis familiaris	STX3	VGNC	VGNC:46955
Macaca mulatta	STX3	VGNC	VGNC:78044
Bos taurus	STX3	VGNC	VGNC:35439
Mus musculus	STX3	MGD	MGI:103077
Others	STX3	NCBI