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UGT2B7 - UDP glucuronosyltransferase family 2 member B7 Gene

Also Known as UGT2B9; UDPGTH2; UDPGT2B7; UDPGTh-2; UDPGT 2B7; UDPGT 2B9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7364

About UGT2B7

Cytogenetic location: 4q13.2 Genomic coordinates (GRCh38): 4:69,051,375-69,112,987 (from NCBI)

This gene has 5 transcripts (splice variants), 1241 orthologues and 21 paralogues. Biased expression in kidney (RPKM 335.9), liver (RPKM 240.7) and 2 other tissues.

Summary

The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]

UGT2B7 Products (3)

mRNA	Protein	Name
NM_001074.4	NP_001065.2	UDP-glucuronosyltransferase 2B7 isoform 1 precursor
NM_001330719.2	NP_001317648.1	UDP-glucuronosyltransferase 2B7 isoform 2 precursor
NM_001349568.2	NP_001336497.1	UDP-glucuronosyltransferase 2B7 isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables glucuronosyltransferase activity	IDA IDA: Inferred from direct assay	17442341	GOA
NOT enables retinoic acid binding	IDA IDA: Inferred from direct assay	20308471	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in androgen metabolic process	IDA IDA: Inferred from direct assay	17442341	GOA
involved in cellular glucuronidation	IDA IDA: Inferred from direct assay	17442341	GOA
involved in estrogen metabolic process	IDA IDA: Inferred from direct assay	18719240	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UGT2B7 Protein Structure

UDPGT

0
100
200
300
400
500
529 a.a.

Protein Preferred Names	Protein Names
UDP-glucuronosyltransferase 2B7	3,4-catechol estrogen specific

Related Diseases

Diseases	Alias
Hepatocellular Adenoma	Adenoma Hepatocellular
Neonatal Abstinence Syndrome	Drug Withdrawal Syndrome In Newborn
Neonatal Candidiasis	Neonatal Candida Infection Neonatal Monilia Infection Neonatal Moniliasis
Gilbert Syndrome	Gilbert Disease Gilbert'S Disease Gilbert'S Syndrome Cholemia, Familial Familial Nonhemolytic Jaundice Meulengracht Syndrome Gilbert Syndrome, Susceptibility To Hyperbilirubinemia, Gilbert Type Hblrg Hyperbilirubinemia, Arias Type Hyperbilirubinemia I Constitutional Hyperbilirubinemia Gilbert-Meulengracht Syndrome Hereditary Nonhemolytic Jaundice Hyperbilirubinemia Arias Type Hyperbilirubinemia Type 1 Constitutional Liver Dysfunction Gilbert-Lereboullet Syndrome Hyperbilirubinemia 1 Unconjugated Benign Bilirubinemia GILBS Gilberts Syndrome Familial Nonhaemolytic Jaundice Constitutional Hyperbilirubinaemia Hereditary Nonhaemolytic Bilirubinaemia Familial Nonhaemolytic Bilirubinaemia Idiopathic Hyperbilirubinaemia Icterus Intermittens Juvenilis Chronic Intermittent Juvenile Jaundice Low-Grade Chronic Hyperbilirubinaemia Syndrome Benign Unconjugated Bilirubinaemia Syndrome Hereditary Nonhaemolytic Jaundice Idiopathic Unconjugated Hyperbilirubinaemia Gilbert--Lereboullet Syndrome Constitutional Hepatic Dysfunction Meulengracht Icterus Cholaemia Familiaris Simplex Familial Cholaemia Congenital Familial Cholaemia Physiologic Cholaemia Hyperbilirubinaemia Type 1 Gilbert Cholaemia
Crigler-Najjar Syndrome, Type I	Crigler-Najjar Syndrome Crigler-Najjar Syndrome Type 1 Bilirubin Udp Glucuronyl Transferase Deficiency Crigler Najjar Syndrome Crigler Najjar Syndrome, Type 1 Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Bilirubin-Ugt Deficiency Hyperbilirubinemia, Crigler-Najjar Type I Hblrcn1 Familial Nonhemolytic Unconjugated Hyperbilirubinemia Hereditary Unconjugated Hyperbilirubinemia Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1 Bilirubin-Ugt Deficiency Type 1 Crigler-Najjar Syndrome 1 CN1 Cn-I Crigler-Najjar Syndrome Type I Hereditary Unconjugated Hyperbilirubinaemia Ugt Deficiency Bilirubin Glucuronosyltransferase Deficiency Crigler-Najjar Disease Or Syndrome Deficiency Of Glucuronosyltransferase Glucuronyl Transferase Deficiency Glucuronyltransferase Deficiency Udp Glucuronyl Transferase Deficiency Cns - [Crigler-Najjar Syndrome] Congenital Familial Nonhemolytic Jaundice
Severe Cutaneous Adverse Reaction	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Drug-Induced Stevens Johnson Syndrome Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum Susceptibility To Severe Cutaneous Adverse Reaction Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Lyell'S Syndrome Lyell Syndrome Severe Cutaneous Adverse Reaction, Susceptibility To Hypersensitivity Syndrome, Carbamazepine-Induced, Susceptibility To Hypersensitivity Syndrome, Carbamazepine-Induced Stevens-Johnson Syndrome, Susceptibility To Toxic Epidermal Necrolysis, Susceptibility To Sjs/Ten Susceptibility To Severe Cutaneous Adverse Reaction Ity To Mycoplasma-Induced Stevens Johnson Syndrome Dermatostomatitis, Stevens Johnson Type Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum Sjs-Ten Toxic Epidermolysis SJS Dermatostomatitis Stevens Johnson Type Ten Sjs/Ten - [Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis] Ten - [Toxic Epidermal Necrolysis]
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Lennox-Gastaut Syndrome	Lennox Syndrome Encephalopathy Of Childhood Epileptic Encephalopathy Lennox-Gastaut Type Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves Lgs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0235	Bakuchiol	Inhibitor	99.25%	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0762	Isobavachin		99.88%	Unkown
HY-137522	Zidovudine O-β-D-glucuronide sodium		99.05%	Unkown
HY-N0859	Schisanhenol	Inhibitor	99.99%	Unkown
HY-125904	4-Hydroxyretinoic acid		≥95.0%	Unkown
HY-106181	Rivoglitazone	Agonist	98.59%	Unkown
HY-130046	16-Epiestriol	Inhibitor	99.04%	Unkown
HY-137522A	Zidovudine O-β-D-glucuronide		/	Unkown
HY-137522S	Zidovudine O-β-D-glucuronide-d3 sodium		≥97.0%	Unkown
HY-N0859R	Schisanhenol (Standard)	Inhibitor	/	Unkown
HY-RS15441	UGT2B7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26709	Ugt2b7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UGT2B7	RGD	RGD:708417