Human UGT2B7
Human UGT2B7 is a UDP-glucuronosyltransferase isoform. Human UGT2B7 catalyzes the glucuronidation of Clopidogrel carboxylic acid (HY-141749A), Chloramphenicol (HY-B0239), and Morphine. Human UGT2B7 can be used in studies related to acute coronary syndrome and thrombus-induced events.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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UGT2B7 |
Human UGT2B7 (30-60 min) catalyzes the glucuronidation of Clopidogrel carboxylic acid (HY-141749A), with a Km value of 296.4 μM and a Vmax value of 120.9 pmol/min/mg protein, and its catalytic efficiency is 3 to 12-fold higher than that of other active recombinant UGT isoforms tested[1].
Human UGT2B7 (50 min) efficiently catalyzes the O-glucuronidation of Chloramphenicol (HY-B0239). Its activity for producing 3-O-glucuronide (CLint = 0.43 L/min/mg protein) is higher than that for producing 1-O-glucuronide (CLint = 0.047 L/min/mg protein), and it is the only tested UGT isoform with significant 1-O-glucuronidation activity[2].
Human UGT2B7 catalyzes the glucuronidation of Morphine[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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SMILES
[Human UGT2B7]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ji JZ, et al. Human UGT2B7 is the major isoform responsible for the glucuronidation of clopidogrel carboxylate. Biopharmaceutics & drug disposition. 2018 Feb;39(2):88-98. [Content Brief]
[2]. Chen M, et al. Identification of human UGT2B7 as the major isoform involved in the O-glucuronidation of chloramphenicol. Drug metabolism and disposition: the biological fate of chemicals. 2010 Mar;38(3):368-75. [Content Brief]
[3]. Coffman B L, et al. Human UGT2B7 catalyzes morphine glucuronidation[J]. Drug Metabolism and Disposition, 1997, 25(1): 1-4. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Human UGT2B7 Related Classifications
HY-E72113 Related Classifications
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