2,5-Dimethylpyrazine
Based on 1 Customer Validation
2,5-Dimethylpyrazine (NSC 49139) is a flavor compound. 2,5-Dimethylpyrazine forms in baked foods. It can also be produced by Bacillus subtilis via microbial mechanisms. 2,5-Dimethylpyrazine imparts baking, nutty, earthy, and cocoa-like aroma characteristics to heated foods. In fully fired oolong tea, 2,5-Dimethylpyrazine exhibits a roasted peanut flavor.
For research use only. We do not sell to patients.
- Purity: 99.99%
- CAS No.: 123-32-0
- Formula: C6H8N2
- Molecular Weight:108.14
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Microbial Metabolite |
2,5-Dimethylpyrazine is a key product of the Maillard reaction, which imparts baking, nutty, earthy, and cocoa-like aroma characteristics to heated foods[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 123-32-0
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Appearance ＜15℃ Solid,＞15℃ Liquid
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Molecular Weight 108.14
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Formula C6H8N2
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Color Light yellow to yellow
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SMILES
CC1=CN=C(C)C=N1
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Synonyms
NSC 49139
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (462.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (23.12 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (23.12 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (454 KB)
- English - EN (454 KB)
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Handling Instructions (2659 KB)
References
[1]. Scalone GLL, et al. Impact of whey protein hydrolysates on the formation of 2,5-dimethylpyrazine in baked food products. Food research international (Ottawa, Ont.). 2020 Jun;132:109089. [Content Brief]
[2]. Zhang L, et al. An Alkylpyrazine Synthesis Mechanism Involving l-Threonine-3-Dehydrogenase Describes the Production of 2,5-Dimethylpyrazine and 2,3,5-Trimethylpyrazine by Bacillus subtilis. Applied and environmental microbiology. 2019 Dec 15;85(24):e01807-19. [Content Brief]
[3]. Guo X, et al. Contribution of l-theanine to the formation of 2,5-dimethylpyrazine, a key roasted peanutty flavor in Oolong tea during manufacturing processes. Food chemistry. 2018 Oct 15;263:18-28. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 9.2473 mL | 46.2364 mL | 92.4727 mL | 231.1818 mL |
| 5 mM | 1.8495 mL | 9.2473 mL | 18.4945 mL | 46.2364 mL | |
| 10 mM | 0.9247 mL | 4.6236 mL | 9.2473 mL | 23.1182 mL | |
| 15 mM | 0.6165 mL | 3.0824 mL | 6.1648 mL | 15.4121 mL | |
| 20 mM | 0.4624 mL | 2.3118 mL | 4.6236 mL | 11.5591 mL | |
| 25 mM | 0.3699 mL | 1.8495 mL | 3.6989 mL | 9.2473 mL | |
| 30 mM | 0.3082 mL | 1.5412 mL | 3.0824 mL | 7.7061 mL | |
| 40 mM | 0.2312 mL | 1.1559 mL | 2.3118 mL | 5.7795 mL | |
| 50 mM | 0.1849 mL | 0.9247 mL | 1.8495 mL | 4.6236 mL | |
| 60 mM | 0.1541 mL | 0.7706 mL | 1.5412 mL | 3.8530 mL | |
| 80 mM | 0.1156 mL | 0.5780 mL | 1.1559 mL | 2.8898 mL | |
| 100 mM | 0.0925 mL | 0.4624 mL | 0.9247 mL | 2.3118 mL |
2,5-Dimethylpyrazine Related Classifications
HY-34439 Related Classifications
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- 2,5-Dimethylpyrazine
- 123-32-0
- NSC 49139
- NSC49139
- NSC-49139
- Endogenous Metabolite
- Biochemical Assay Reagents
- L-threonine-3-dehydrogenase
- Bacillus subtilis
- whey protein hydrolysates
- 5-methylpyrazine-2-carboxylic acid
- aminoacetone
- Aspergillus melleus
- 2-amino-3-ketobutyrate CoA ligase
- whey protein isolate
- L-threonine
- Maillard reaction
- Inhibitor
- inhibitor
- inhibit