ERα-IN-3
ERα-IN-3 is a ERα inhibitor with an IC50 of 74.48 μM. ERα-IN-3 induces cell cycle arrest at the G0/G1 and G2/M checkpoints and triggers Apoptosis. ERα-IN-3 exhibits anticancer effects against ER-positive breast cancer. ERα-IN-3 can be used for the research of ERα-positive breast cancer.
For research use only. We do not sell to patients.
- Formula: C25H21N3O4
- Molecular Weight:427.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ERα 74.48 μM (IC50) |
ERα-IN-3 (Compound 20) at concentrations of 2-32 μM potently inhibits the proliferation of ER-positive breast cancer cell line T-47D, with an IC50 value of 9.666 μM. Its activity in this cell line is superior to that of Tamoxifen (HY-13757A) and Bazedoxifene (HY-A0031)[1].
ERα-IN-3 inhibits ERα with an IC50 value of 74.48 μM[1].
ERα-IN-3 (25 μM; 48 h) induces cell cycle arrest in T-47D cells, primarily at the G0/G1 phase (59.7%), with additional arrest at the G2/M phase (26.3%)[1].
ERα-IN-3 (25 μM; 48 h) induces apoptosis in approximately 40% of T-47D breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:T-47D
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Concentration:25 μM
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Incubation Time:48 h
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Result:Induced cell cycle arrest with 59.7% of cells in the G0/G1 phase, 9.8% in the S phase, and 26.3% in the G2/M phase.
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Cell Line:T-47D
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Concentration:25 μM
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Incubation Time:48 h
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Result:Induced total apoptosis in approximately 40% of T-47D cells.
Showed early and late apoptotic populations lower than those induced by compound 21 and bazedoxifene but higher than those induced by tamoxifen.
Chemical Information
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Molecular Weight 427.45
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Formula C25H21N3O4
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SMILES
O=[N+](C1=CC(C2=NOC(C3=CN(CC4=CC=CC(OC)=C4)C5=C3C=CC=C5)C2)=CC=C1)[O-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ERα-IN-3 Related Classifications
HY-184732 Related Classifications
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