Dld - dihydrolipoamide dehydrogenase Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13382

Summary

This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. [provided by RefSeq, Jan 2014]

Dld Products (1)

mRNA Protein Name
NM_007861.5 NP_031887.2 dihydrolipoyl dehydrogenase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables dihydrolipoyl dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
9405644 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
29128334 MGI
Biological Process GO Annotation Evidence References Source
involved in acetyl-CoA biosynthetic process from pyruvate IMP
IMP: Inferred from mutant phenotype
17314311 MGI
acts upstream of or within gastrulation IMP
IMP: Inferred from mutant phenotype
9405644 MGI
acts upstream of or within mitochondrial electron transport, NADH to ubiquinone IMP
IMP: Inferred from mutant phenotype
15009635 MGI
acts upstream of or within proteolysis IDA
IDA: Inferred from direct assay
17404228 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
15009635 MGI
acts upstream of or within sperm capacitation IDA
IDA: Inferred from direct assay
15888450 MGI
Cellular Component GO Annotation Evidence References Source
part of acetyltransferase complex IMP
IMP: Inferred from mutant phenotype
9405644 MGI
located in acrosomal matrix IDA
IDA: Inferred from direct assay
15888450 MGI
located in cilium IDA
IDA: Inferred from direct assay
15888450 MGI
is active in mitochondrial matrix IDA
IDA: Inferred from direct assay
9405644 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
15888450 MGI
part of oxoglutarate dehydrogenase complex IMP
IMP: Inferred from mutant phenotype
15356189 MGI
part of pyruvate dehydrogenase complex IMP
IMP: Inferred from mutant phenotype
9405644 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dihydrolipoyl dehydrogenase, mitochondrial

  • branched chain alpha-keto acid dehydrogenase complex subunit E3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (27)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122312 BAY-8002 Inhibitor 98.84% Unkown
HY-139691 SR15006 Inhibitor 99.90% Unkown
HY-177512 MSC778 Inhibitor / Unkown
HY-119257 ABT-100 ≥98.0% Unkown
HY-169652 NPC26 Activator 98.0% Unkown
HY-156375 PKM2 activator 6 / Unkown
HY-120667 DS-5272 / Unkown
HY-118829 3,4-Methylenedioxy PV9 hydrochloride 99.90% Unkown
HY-153674 PROTAC SOS1 degrader-4 Degrader / Unkown
HY-161654 PROTAC SOS1 degrader-10 / Unkown
HY-163816 Antiproliferative agent-53-d3 Inhibitor / Unkown
HY-165606 SB-T-1214 Inducer / Unkown
HY-168716 SOS1-IN-17 Inhibitor / Unkown
HY-168733 LDHA-IN-9 / Unkown
HY-176701 PRMT5-MTA-IN-4 Inhibitor / Unkown
HY-177967 Antitumor agent-209 / Unkown
HY-179413 Polθ-IN-9 Inhibitor / Unkown
HY-RS03794 DLD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04711 FAM3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07574 LDHD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121619 Jacaric acid Inducer / Unkown
HY-122063 FR260330 Inhibitor / Unkown
HY-N13886 Anicequol / Unkown
HY-N7305 Jatrophane 5 Inhibitor / Unkown
HY-RS19107 Dld Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25597 Dld Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W098807 4-Chloro-7-ethoxyquinoline / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dld NCBI NCBI:1738