4-Chloro-7-ethoxyquinoline
4-Chloro-7-ethoxyquinoline (Compound 9a), a quinolone derivative, is an anticancer agent. 4-Chloro-7-ethoxyquinoline can inhibit proliferation of HCT-116, RKO, DLD1, HepG2, BGC-823, NCI-H1650 and SK-OV-3 cells with IC50 values of 3.16, 3.87, 2.75, 2.66, 3.91, 3.34 and 3.46μM.
For research use only. We do not sell to patients.
- CAS No.: 178984-50-4
- Formula: C11H10ClNO
- Molecular Weight:207.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BGC-823 | IC50 |
3.91 μM
Compound: 9a
|
Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay
Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay
|
[PMID: 30496987] |
| DLD-1 | IC50 |
2.75 μM
Compound: 9a
|
Cytotoxicity against human DLD1 cells after 48 hrs by MTT assay
Cytotoxicity against human DLD1 cells after 48 hrs by MTT assay
|
[PMID: 30496987] |
| HCT-116 | IC50 |
3.16 μM
Compound: 9a
|
Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
|
[PMID: 30496987] |
| HepG2 | IC50 |
2.66 μM
Compound: 9a
|
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
|
[PMID: 30496987] |
| NCI-H1650 | IC50 |
3.34 μM
Compound: 9a
|
Cytotoxicity against human NCI-H1650 cells after 48 hrs by MTT assay
Cytotoxicity against human NCI-H1650 cells after 48 hrs by MTT assay
|
[PMID: 30496987] |
| RKO | IC50 |
3.87 μM
Compound: 9a
|
Cytotoxicity against human RKO cells after 48 hrs by MTT assay
Cytotoxicity against human RKO cells after 48 hrs by MTT assay
|
[PMID: 30496987] |
| SK-OV-3 | IC50 |
3.46 μM
Compound: 9a
|
Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay
Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay
|
[PMID: 30496987] |
Chemical Information
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CAS No. 178984-50-4
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Molecular Weight 207.66
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Formula C11H10ClNO
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SMILES
ClC=1C=CN=C2C=C(OCC)C=CC12
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)