Cat. No.: HY-101017

Palmitoylcarnitine chloride

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Palmitoylcarnitine chloride is a fatty acid-derived mitochondrial substrate, and selectively decreases cell survival in colorectal and prostate cancer cells by affecting on pro-inflammatory pathways, Ca²⁺ influx, and DHT-like effects.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 6865-14-1
Formula: C₂₃H₄₆ClNO₄
Molecular Weight:436.07

Storage:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Palmitoylcarnitine chloride Chemical Structure

CAS No.: 6865-14-1

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

All Endogenous Metabolite Isoforms :

All Akt Isoforms :

All Calcium Channel Isoforms :

In Vitro

Palmitoylcarnitine (5-20 μM, 5 min) increases [Ca²⁺]i in a dose-dependent manner in adult rat cardiomyocytes, with 15 μM showing a significant and reversible effect without affecting cell viability^[2].
Palmitoylcarnitine (15 μM, 5 min) increases [Ca²⁺]i in adult rat cardiomyocytes through L-type Ca²⁺ channels, Na⁺-Ca²⁺ exchange, and sarcoplasmic reticulum Ca²⁺ release^[2].
Palmitoylcarnitine (5, 10 μM, overnight) inhibits Akt Ser473 phosphorylation and reduces insulin signaling in C2C12 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

C2C12 myoblasts (mouse skeletal muscle)
Concentration:

5, 10 μM
Incubation Time:

overnight incubation (12 h)
Result:

Reduced insulin-stimulated Akt Ser473 phosphorylation.

In Vivo

Palmitoylcarnitine (10 mg/kg, s.c., once daily for 28 days) induces insulin resistance and hyperinsulinemia, leading to glucose metabolism impairment in CD-1 mice^[3].
Palmitoylcarnitine (50 mg/kg, s.c., single dose) reduces insulin sensitivity and induces glucose intolerance and metabolic dysfunction in CD-1 mice^[3].
Palmitoylcarnitine (50 mg/kg, i.p., single dose) increases muscle long-chain acylcarnitine content and induces insulin resistance in CD-1 mice, characterized by hyperglycemia and reduced muscle glucose uptake^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Palmitoylcarnitine (HY-126357)-induced insulin resistance CD-1 mouse model^[3]
Dosage:

50 mg/kg (s.c. or i.p., single dose) or 10 mg/kg (s.c., long-term administration)
Administration:

Intraperitoneal injection (i.p.), single dose;
Continuously released for 24 hours via a subcutaneous osmotic minipump (s.c.)., single dose
Subcutaneous osmotic minipump (s.c.), once daily for 28 days.
Result:

Increased muscle long-chain acylcarnitine content, elevated blood glucose levels in both fasted and fed states, and decreased muscle glucose uptake (i.p.).
Induced glucose intolerance, delayed energy metabolism shift, and reduced insulin sensitivity (s.c., single dose).
induced insulin resistance and hyperinsulinemia, blocked insulin-mediated blood glucose reduction, increased blood lactate levels, and impaired glucose metabolism (s.c., long-term administration).

Chemical Information

CAS No. 6865-14-1
Appearance Solid
Molecular Weight 436.07
Formula C₂₃H₄₆ClNO₄
Color White to off-white
SMILES

CCCCCCCCCCCCCCCC(OC(CC(O)=O)C[N+](C)(C)C)=O.[Cl-]
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (2)

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
NPJ Biofilms Microbiomes

Gut bacteria facilitate leaf beetles in adapting to dietary specialization by enhancing larval fitness. [Abstract]

2024 Oct 22;10(1):110. PMID: 39438487

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (114.66 mM; Need ultrasonic)

DMSO : 8.33 mg/mL (19.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2932 mL

11.4660 mL

22.9321 mL

5 mM

0.4586 mL

2.2932 mL

4.5864 mL

10 mM

0.2293 mL

1.1466 mL

2.2932 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume

Molecular Weight

Dilution Calculator

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Al-Bakheit A, et al. Accumulation of Palmitoylcarnitine and Its Effect on Pro-Inflammatory Pathways and Calcium Influx in Prostate Cancer. Prostate. 2016 Oct;76(14):1326-37. [Content Brief]

[2]. Netticadan T, et al. Palmitoyl carnitine increases intracellular calcium in adult rat cardiomyocytes. J Mol Cell Cardiol. 1999 Jul;31(7):1357-67. [Content Brief]

[3]. Liepinsh E, et al. Acute and long-term administration of palmitoylcarnitine induces muscle-specific insulin resistance in mice. Biofactors. 2017 Sep 10;43(5):718-730. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	2.2932 mL	11.4660 mL	22.9321 mL	57.3302 mL
	5 mM	0.4586 mL	2.2932 mL	4.5864 mL	11.4660 mL
	10 mM	0.2293 mL	1.1466 mL	2.2932 mL	5.7330 mL
	15 mM	0.1529 mL	0.7644 mL	1.5288 mL	3.8220 mL
H₂O	20 mM	0.1147 mL	0.5733 mL	1.1466 mL	2.8665 mL
	25 mM	0.0917 mL	0.4586 mL	0.9173 mL	2.2932 mL
	30 mM	0.0764 mL	0.3822 mL	0.7644 mL	1.9110 mL
	40 mM	0.0573 mL	0.2867 mL	0.5733 mL	1.4333 mL
	50 mM	0.0459 mL	0.2293 mL	0.4586 mL	1.1466 mL
	60 mM	0.0382 mL	0.1911 mL	0.3822 mL	0.9555 mL
	80 mM	0.0287 mL	0.1433 mL	0.2867 mL	0.7166 mL
	100 mM	0.0229 mL	0.1147 mL	0.2293 mL	0.5733 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Palmitoylcarnitine chloride

2 Cited Publications

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Palmitoylcarnitine chloride

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Publications Citing Use of MedChemExpress (MCE) Palmitoylcarnitine chloride

All Endogenous Metabolite Isoforms

All Akt Isoforms

All Calcium Channel Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Palmitoylcarnitine chloride Related Classifications

Cat. No.: HY-101017