2-Thiocytidine
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2-Thiocytidine is a natural thionucleoside in prokaryotic tRNA, which is biosynthesized under the catalysis of intracellular sulfur transferase systems and possesses multiple activities such as metal coordination and nucleic acid conformation regulation. 2-Thiocytidine forms stable Zn2+ and Cd2+ complexes via its (C2) S group, with partial involvement of N3; metal binding acidifies the deprotonation process of (C4) NH2. 2-Thiocytidine can be used in related research in various fields including nanotechnology and click chemistry for interstrand DNA crosslinking.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.23%
- CAS 番号: 13239-97-9
- 分子式: C9H13N3O4S
- 分子量:259.28
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
2-Thiocytidine (C2S) has a pKa value of 3.44 in aqueous solution and exhibits stronger acidity than monoprotonated cytidine; deprotonation of this molecule occurs in water with a corresponding pKa of 12.65[1].
2-Thiocytidine (0.4 mM) forms Zn (C2S)2+ and Zn (C2S-H)+ complexes in aqueous solution, where the (C2) S serves as the primary binding site for Zn2+[1].
2-Thiocytidine (0.4 mM) forms Cd (C2S)2+ and Cd (C2S-H)+ complexes in aqueous solution, where (C2) S serves as the primary binding site for Cd2+[1].
2-Thiocytidine can be efficiently incorporated into a DY647-labeled, triple-modified 17-mer RNA sequence via solid-phase phosphoramidite synthesis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 13239-97-9
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性状 Solid
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分子量 259.28
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分子式 C9H13N3O4S
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Color White to off-white
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SMILES
S=C1N([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C=CC(N)=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 125 mg/mL (482.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8568 mL | 19.2842 mL | 38.5683 mL | 96.4209 mL |
| 5 mM | 0.7714 mL | 3.8568 mL | 7.7137 mL | 19.2842 mL | |
| 10 mM | 0.3857 mL | 1.9284 mL | 3.8568 mL | 9.6421 mL | |
| 15 mM | 0.2571 mL | 1.2856 mL | 2.5712 mL | 6.4281 mL | |
| 20 mM | 0.1928 mL | 0.9642 mL | 1.9284 mL | 4.8210 mL | |
| 25 mM | 0.1543 mL | 0.7714 mL | 1.5427 mL | 3.8568 mL | |
| 30 mM | 0.1286 mL | 0.6428 mL | 1.2856 mL | 3.2140 mL | |
| 40 mM | 0.0964 mL | 0.4821 mL | 0.9642 mL | 2.4105 mL | |
| 50 mM | 0.0771 mL | 0.3857 mL | 0.7714 mL | 1.9284 mL | |
| 60 mM | 0.0643 mL | 0.3214 mL | 0.6428 mL | 1.6070 mL | |
| 80 mM | 0.0482 mL | 0.2411 mL | 0.4821 mL | 1.2053 mL | |
| 100 mM | 0.0386 mL | 0.1928 mL | 0.3857 mL | 0.9642 mL |
2-Thiocytidine 関連分類
HY-W244398 関連分類
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